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41 Cards in this Set
- Front
- Back
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osteoarthritis
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wear-and-tear of joints -> destruction of articular cartilage, subchondral bone formation, sclerosis, osteophytes, eburnation, Herberden's nodes (DIP), Bouchard's nodes (PIP)
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What is the classic presentation of osteoarthritis?
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pain in weight-bearing joints after use, improving w/ rest, no systemic symptoms
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rheumatoid arthritis
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inflammatory disorder affecting synovial joints
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What is the classic presentation of rheumatoid arthritis?
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morning stiffness improving w/ use, symmetric joint involvement, systemic symptoms
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Which form of arthritis presents w/ systemic symptoms? Rheumatoid arthritis or Osteoarthritis?
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rheumatoid arthritis
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Which form of arthritis gets better as the day progresses?
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rheumatoid arthritis
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Which form of arthritis improves after rest?
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osteoarthritis
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Which form of arthritis presents w/ pain in weight-bearing joints?
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osteoarthritis
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Which form of arthritis presents w/ ulnar deviation of the hand?
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rheumatoid arthritis
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Boutonniere deformity is a feature of what disease?
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rheumatoid arthritis
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Swan-neck deformity is a feature of what disease?
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rheumatoid arthritis
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Z-thumb deformity is a feature of what disease?
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rheumatoid arthritis
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Sjogren's syndrome
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xerophthalmia (dry eyes, conjunctivitis)
xerostomia (dry mouth, dysphagia) arthritis parotid enlargement increased risk of B-cell lymphoma |
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Sjogren's syndrome is associated w/ what disease?
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rheumatoid arthritis
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Sjogren's syndrome predominantly affects what population?
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females b/w 40-60 years old
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gout
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precipitation of monosodium urate crystals into joints due to hyperuricemia
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Which joint does gout primarily manifest?
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MTP of big toe (podagra)
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What is the treatment for gout?
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allopurinol, probenecid, colchicine, NSAIDs
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When do acute attacks of gout tend to occur?
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after alcohol consumption or after a large meal
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pseudogout
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deposition of calcium pyrophosphate crystals w/in the joint space
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Which joints does pseudogout tend to affect?
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large joints (classically the knee)
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What is the treatment for pseudogout?
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none
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celiac sprue
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autoimmune-mediated intolerance of gliadin (wheat) -> steatorrhea
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Celiac sprue is associated w/ people of what descent?
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Northern European descent
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Celiac sprue is associated w/ what disease?
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dermatitis herpetiformis
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What are the symptoms of systemic lupus erythematosus?
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fever, fatigue, wt. loss, nonbacterial verrucous endocarditis, Raynaud's phenomenon, malar rash
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Systemic lupus erythematosus causes a false positive on what test?
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syphilis test (RPR/VDRL) due to antiphospholipid antibodies
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Systemic lupus erythematosus is most common and severe in what population?
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black females
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Sarcoidosis is common in what population?
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black females
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What are the characteristics of sarcoidosis?
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(GRAIN)
Gammaglobulinemia Rheumatoid arthritis ACE increase Interstitial fibrosis Noncaseating granulomas |
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ankylosing spondylitis
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chronic inflammatory disease of spine and sacroiliac joints -> ankyolsis, uveitis, aortic regurgitation
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Reiter's syndrome
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urethritis
conjunctivitis and anterior uveitis arthritis |
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scleroderma
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excessive fibrosis and collagen deposition throughout the body
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diffuse scleroderma
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widespread skin involvement, rapid progression, early visceral involvement
associated w/ anti-Scl-70 antibody |
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CREST syndrome
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Calcinosis
Raynaud's phenomenon Esophageal dysmotility Sclerodactyly Telangiectasia limited skin involvement (often confined to fingers and face) associated w/ anticentromere antibody |
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psoriasis
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nonpuritic chronic inflammation of the skin, particularly on knees and elbows
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Psoriasis is associated w/ what alleles?
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HLA-B27
HLA-13 HLA-17 |
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bullous pemphigoid
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autoimmune disorder w/ IgG antibody against epidermal basement membrane
similar to pemphigus vulgaris, but less severe affects skin but spares oral mucosa |
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pemphigus vulgaris
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potentially fatal autoimmune skin disorder
intradermal bullae involving the oral mucosa and skin IgG antibody against epidermal cell surface |
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Goodpasture's syndrome
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pulmonary hemorrhages -> hemoptysis
renal lesions -> hematuria, anemia, crescentic glomerulonephritis anti-GBM antibodies -> linear staining on immunofluorescence |
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Goodpasture's syndrome is most common in what population?
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men b/w 20-40 years old
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