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16 Cards in this Set
- Front
- Back
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Neuromuscular Junction. 1. Motor neuron- _____ meets muscle fiber, contraction occurs only when muscle fibers stimulates by its ____ motor neuron. |
Neuromuscular Junction. 1. Motor neuron- nerve cellmeets muscle fiber, contraction occurs only when muscle fibers stimulates by its own_ motor neuron. |
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Neuromuscular Junction. 2. Neuromuscular junction-connection b/n two= ____ space= synaptic cleft.
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Neuromuscular Junction. 2. Neuromuscular junction-connection b/n two= synapse space= synaptic cleft.
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Neuromuscular Junction.3. Motor end plate-specilized region of sarcolemma that is ___ and contains many _____
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Neuromuscular Junction.3. Motor end plate-specilized region of sarcolemma that is folded
and contains many mitchondria |
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Neuromuscular Junction. 4. neurotransmitters- synaptic vesicles containing NT are _____, release NT from end of motor neuron onto muscle fiber=synaptic transmission.
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Neuromuscular Junction. 4. neurotransmitters- synaptic vesicles containing NT are exocytosed, release NT from end of motor neuron onto muscle fiber=synaptic transmission.
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Excitation/Contraction coupling.1.electrochemical signal aka _____. -____ enters stimulates NT release from motor neuron across synaptic cleft to motor end plate. NT= ________ Ach. Botulinus toxin ____ from bacteria, inhibits release of Ach, no muscle contraction including ____. |
Excitation/Contraction coupling. Electrochemical signal aka actin potential. -CaH
enters stimulates NT release from motor neuron across synaptic cleft to motor end plate. NT= acetylcholine Ach. Botulinus toxin botulism from bacteria, inhibits release of Ach, no muscle contraction including respiration. |
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Excitation/Contraction coupling. 2. Binds post-synaptic cholinergic receptors. Two Ach _____ per channel-opens Na & K channels which allows action potential to propagate over entire muscle fiber
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receptors |
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Excitation/Contraction coupling.3. Muscle impulse-generated by #2. over sarcolemma and through ____ into fiber
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T-Tubules |
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Excitation/Contraction coupling.4. Ca++ release from _____ in response to activiated T-tubules, Ca++ diffuses into _____
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sarcoplasmic reticulum, sarcoplasm |
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Excitation/Contraction coupling.5. Allows actin/myosin ______ > contraction
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interaction |
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Excitation/Contraction coupling.6. _____ enzyme causes Ach ____ at NMJ. Lose stimulus. Repolarized muscle fiber membrane.
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Acetylcholinesterase, breakdown |
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Excitation/Contraction coupling.7, Ca_____ from sarcoplasm by _____ via SR Ca++/ATPase pump.
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removed, active transport. |
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Excitation/Contraction coupling.8. Actin/myosin linkages ____. 9. Relaxation
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broken |
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Crossbridge cycle. 1. Inhibitory proteins b/n actin + myosin keep them from interacting. a. ____ threadlike entwines actin. ____ globular, provides ____ binding site. |
tropomysin, tropnin, Ca |
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Crossbridge cycle.2. In presence of Ca++, ____ moved tropomyosin to allow actin to bind to ____ or head of myosin = _____. Racheting pulls actin closer pulling Z lines together and shortening ____
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Crossbridge cycle.2. In presence of Ca++, troponin moved tropomyosin to allow actin to bind to ratchet or head of myosin = crossbridge formation. Racheting pulls actin closer pulling Z lines together and shorteningsarcomere
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Crossbridge cycle. 3. ATP-Necessary energy to ___ and ___.
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release and reset |
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Crossbridge cycle. 4. Release/reset/pull gives shortening and contraction. Z lines pulled closer together over many strokes. ______ - contraction of muscles few hours after death due to increase in Ca++ _____ + ATP depletion so filamengts cannot ____.
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Crossbridge cycle. 4. Release/reset/pull gives shortening and contraction. Z lines pulled closer together over many strokes. Rigor Mortis- contraction of muscles few hours after death due to increase in Ca++ permeability + ATP depletion so filamengts cannotrelease
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