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50 Cards in this Set
- Front
- Back
genetic locus |
the specific location of a gene or piece of DNA sequence on a chromosome. Mutations can modify these, creating new alleles. |
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population genetics |
study of the distribution of alleles within populations and the mechanisms that can cause allele frequencies to change over time. |
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fixed allele |
an allele becomes fixed in a population when all of the alternative alleles have disappeared. no genetic variation exists at a fixed locus within a population because all individuals are genetically identical at that locus. easier in smaller populations |
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additive allele |
an allele that yields twice the phenotypic effect when homozygous instead of hetero. is not influenced by presence of other alleles, so no dominance. since it always has a phenotype, very prone to selection to fixation or being wiped out of population |
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mutation selection balance |
maintain genetic variation through the introduction of new alleles via mutation. While selection selects against the deleterious allele, new mutations at that locus will keep emerging, increasing its frequency. This creates a "tug-o-war", balancing genetic variation. |
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migration selection balance |
disadvantageous genes can often be maintained in a population by migration from populations where the gene is favored. Spatially varying selection is common, for instance in the banded vs unbanded water snake migrating through mainland islands |
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negative frequency dependent selection |
rare genotypes have higher fitness than common genotypes. this process can maintain genetic variation within populations. yellow and purple Elder orchid flowers tricking bees. |
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fitness |
the success of an organism at surviving and reproducing, and thus contributing offspring to future generations. The product of the entire phenotype. |
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relative fitness (of a genotype) |
(w= 0-1) the success of the genotype at producing new individuals (its fitness)standardized by the success of other genotypes in the populations (ex. divided by avg fitness of population) fitness as compared to highest fitness |
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Average excess of fitness (of an allele) |
the difference between the average fitness of individuals bearing the allele and the average fitness of a population as a whole Delta p= p x (a/w), delta p= change in allele freq due to selection, p = freq of allele, a = avg excess of fitness of that allele, w = avg fitness of pop'n |
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inbreeding coefficient |
(F) the probability that the two alleles at any locus in an individual will be identical by decent. Higher F = more inbred |
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Het advantage |
overdominance. NS works to increase diversity because is selecting for het. Malaria and sickle cell, Cystic Fibrosis and Typhoid Fever. Neither allele can EVER become fixed. Het relative fitness always 1. |
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het disadvantage |
underdominance. relative fitness 1-x. does not maintain diversity, because NS selecting for homozygotes. |
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5 assumptions of HW |
1. random mating, large pop 2. no migration 3. no genetic drift 4. no mutation 5. no natural selection |
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HW equation to calc allele freq and expected genotype freq |
p + q = 1 P^2 + 2pq + q^2 = 1 |
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positive frequency dependent selection |
increases genetic uniformity. fitness increases a genotype becomes more common |
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inbreeding |
mating with relatives or self fertilizing. increases deleterious genes, decreases fitness. More homozygotes, less HW equilibrium. Prairie chickens in Illinois |
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allele freq vs. genotype freq in inbreeding |
allele freq in the next generation are the same, but it does change the genotype freq. That's the problem. |
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inbreeding depression |
negative effects of inbreeding on offspring due to increasing homozygosity in individuals. reduced fertility/growth, higher mortality, diseases, etc |
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2 effects of inbreeding |
1. homozygosity- loss of variation, loss of genes associated with immunity (hybrid vigor, MHC loci) 2. Inbreeding Depression- negative effects (due to het advantage) |
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Identity by Descent |
matchingsegment of DNA shared by two or more people that has been inherited from arecent common ancestor without any intervening recombination.
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inbreeding coefficient |
probabilitythat 2 alleles are identical by descent; involves tracing of paths between thetwo parents via a common ancestor-> |
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F for half sibs, whole sibs, and self-ferts |
F = 1/8 F = 1/4 F = 1/2 |
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mechanisms hermaphrodites use to avoid self-ferting |
1. temporal- 1st one sex released, then the other. coral spawning events. 2. physical- male and female games in different parts of body or different genetic types. Earthworms, 2 pollen grains in plants where only one grows. |
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purifying selection |
when inbreeding purges out lethal recessive alleles, like in cheetah populations |
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sexual reproduction |
Process that requires a fertilization event inwhich two gametes unite. uses meiosis. |
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Asexual reproduction |
1 parent, offspring nearly identical copies. uses mitosis. |
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sexual reproduction pros |
sexual have more variation (mutations, recombination, random mating, random assortment), recombination reduced linkage disequilibrium |
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sexual rep cons |
2 fold cost- slow and only half the offspring can directly produce offspring themselves (females) |
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asexual pros |
faster, don't have to mix DNA so you get all your good DNA in offspring |
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asexual cons |
no DNA mixing, so get all of your bad DNA, too. not as many chances for genetic variance. |
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Muller's Ratchet |
process by which asexual genomes produce deleterious alleles irreversibly. |
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the red queen hypothesis |
Sexual populations are able to keep up or adaptto new selective challenges, while the asexual populations, essentially clonal,are not. Asexual reproducers may have slight disadvantage. Trematode worm parasite in New Zealand Mud Snail |
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In what scenario is sex more likely to evolve? Why? |
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reproductive success |
Numberof offspring, survival, fecundity, mating success. Really proxies for alleles passed on in lifetime(fitness). Male vs. Female elephant seals
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Bateman-TriversTheory
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Asymmetry in parental investment. Typical Male cheap sperm but Maximum number of offspring is limited by Number of eggs he can fertilize Typical Femalehas expensive eggs but Output limited by Number of eggs she can produce
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fecundity in males |
(1) Small gamete size(2) Low investment(3) Produce many(4) Not limited by resources
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fecundity in females |
(1) Large gamete size(2) High investment(3) Produce a few(4) Limited by resources
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sexual dimorphism |
higher opportunity for mating success means greater selection on morphology, leading to sexual dimorphism. influences reproductive success. |
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RS in Peacocks |
males have higher variance |
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RS in Albatross |
little sexual dimorphism, but female eggs are still more expensive |
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RS in Red-neck Phalarope |
females are more colorful, court males who do parental care. Polyandry. Still expensive eggs, so less big than in polygyny |
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4 reasons for sexual selection |
1.Fundamental asymmetry in parental investment (Females invest more) 2. Difference in variance in reproductive success(Males have greater variance in fitness) 3. Selection (as we know from NS) acts on variance in fitness((Sexual) selection should be stronger on males) 4. Phenotypic consequence is sexual dimorphism(Morphology, Behavior, physiology)
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4 postulates of natural selection |
1. individuals within a population are variable 2. variations are heritable 3. individuals vary in survival and reproductive success 4. survival and reproduction are not random. |
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linnaeus |
organized all known living things at the time into taxa groups. father of taxonomy. |
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Lamark |
lamarkian evolution. animals could evolve quickly and pass down acquired traits. |
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hutton |
world was shaped by gradual transformations of landscapes through imperceptibly long changes |
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lyell |
earths landscapes created my a series of many small changes still occurring today. |
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wallace |
English naturalist who wrote a theory similar to darwins and inspired him to finally publish. wrote to darwin. |
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malthus |
English clergyman who wrote Principle of population, saying population growth would always outstrip the govt's efforts to help feed the poor. those who could adapt to societal needs and provide useful work would survive. |