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12 Cards in this Set
- Front
- Back
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EBV is a member of the _______ virus family |
herpes |
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EBV causes _______ ____________. |
infectious mononucleosis |
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EBV is a ______-stranded ___ virus |
double-stranded DNA virus |
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Mono is often called the " ______ " disease |
kissing: primarily transmitted via saliva |
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Symptoms of mono? |
Fever, sweats, fatigue, swollen tonsils - tender lymphadenopathy (generally in post. cervical region), also can get generalized lymphadenopathy Pharyngitis and tonsillar exudates. How do you distinguish strep pharyngitis from mono? strep- more often seen in kids and adolescents. Mono is usually asymptomatic at a young age. More so in late teens and young adults. Patients iwth mono that get treated with amox or ampicilin. will develop a maculopapular rash (not an allergy... mech not understood) |
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What would you see on a blood smear of someone with mono? |
Reactive CD8+ T cells (Downy, or atypical cells) (knight with sword) "Reactive lymphocytosis" Large with lots of cytoplasm. Oval, indented or folded nucleus. -- can be seen in many different settings, but most well known for mono |
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Atypical lymphocytes are mostly CD8+ but can also be ____ cells. WHy do you get splenomegaly? |
NK- Both CD8+ and NK cells proliferate which is why your spleen and lymph nodes become enlarged. |
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EBV remains latent in __ Cells. How does this cell get infected? |
B! B cells get infected by the EBV envelope glycoprotein binds to CD21 (Must B 21 to drink). |
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EBV is also a risk factor for some cancers.. what are they? |
In patients with weakened immune systems, -B cell lymphoma -Hodgkins - Reed-Sternberg cells that look like owl's eyes. -Non-Hodgkins - many but one example: Burkitt - endemic or african - large jaw lesion and swelling. In non-endemic or sporadic, it develops in the ileocecum and peritoneum. Most common translocation is t8 - 14 -Nasopharyngeal carcinoma (asian ancestry) |
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What is another disease caused by EBV that is not precancerous? |
Oral Hairy Leukoplakia in HIV patients (guy with long beard and cane). Cant scrape them off - does not develop into squamous cell carcinoma |
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How is EBV diagnosed? |
during the acute infection EBV activates B cells to secrete heterophile antisheep red blood cell antibodies. They will agglutinate or clump sheep or horse RBCs with the Monospot test! |
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Treatment of mono caused by EBV? |
No drug treatment. Avoid contact sports for risk of splenic rupture. |
