Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
What are CAD equivalents?
|
DM, Aortic aneurysm, PVD,TIA, stroke, 10 year risk for CAD >20% using Framingham risk scale.
|
|
Who should be screened for dyslipidemia?
|
Generally male > 35, female >45
According to USPSTF male 20-35 or female 20-45. Regardless of age, all patients with known CHD, or CAD equivalents should be screened. |
|
What are the causes of 2nd causes of dyslipidemia?
|
Tobacco, EtOH, hypothyroid, DM, obstructive liver dz, renal failure, nephrotic syndrome.
|
|
What should clinicians advice pt with dyslipidemia about life stylestyle changes?
|
Diet- rich in fruits, veggies, nuts, and whole grain, low in red meat and animal fat. Increase soy consumption.
|
|
When should drug therapy recommended for dyslipidemia?
|
depends on underlying RFs.
1. if none or 1 CHD RF, then 6 months of lifestyle mod. 2. if CAD or equilalent with LDL >100, start therapy. 3.if high risk CVD, treat LDL goal of <70. 4. If hospitalized for a CAD event. Start therapy. i.e. statins. |
|
What the goals drug therapy of dyslipidemia?
|
Treat LDL first!
1. for high LDL, statin first, absorption blocker, niacin. 2. for High LDL and low HDL; statin 1st and niacin 2nd. 3. for High LDL and low HDL high TG; statin and niacin 1st, fibrate 2nd. 4. high TG levels consider fibrates and niacins 5. low HDL. niacin 1st, fibrate 2nd. |
|
What cautions during drug tx for dyslipidemia?
|
be vigilant for drug interactions. Fibrates should be used with cautions when combine with statins (gemfibrozil) compete for metabolism via CP450, may induce rabdomyolysis.
|
|
What are the SE of drug therapy for dyslipidemia?
|
myalgias, myositis, increased LFT and (rare) rhabdomyolysis.
|
|
What are some SE of Fibrates?
|
can cause nausea and skin rash.
|
|
What are some SE of Niacin?
|
Can cause flushing, nausea, HA, glucose intolerance and gout. ASA can minimize flushing 1 hrs prior to taking niacin.
|