Dr. Schriefer Femal Sex Steroids Repro Test 1

Front 1

Estrogens MOA

Back 1

binds to estrogen response slements on various genes and regulates their transcription resulting in protein synthesis affects vary by cell type and location

Front 2

Physiological effects of estrogens

Back 2

femal maturation, development of vagina, uterus, fallopian tubes, secondary sex traits, and development of endometrial lining

Front 3

Metabolic effects of estrogens

Back 3

decreases bone resorption, increases HDL and decreases LDL and total cholesterol, decreases bile acids, and alters production and activity of binding proteins

Front 4

Side effects of estrogens

Back 4

increases factors 2,7,9, and 10 and decreases antithrombin III, edma, induce synthesis of progesteron receptors, and behavorial effects

Front 5

Why can't you take 17-estradiol beta orally?

Back 5

Nature estrogens and their esters are not effectives orally due to sinificant first pass hepatic metabolism and are excreted renally and biliary

Front 6

Conjugated Equine Estrogens how are they administered and what do they treat?

Back 6

oral, menopause

Front 7

How is estradiol (17) given?

Back 7

transdermally, menopause

Front 8

How are the esters given (-ate)

Back 8

injection, menopause

Front 9

Side effects of etrogens as a drug

Back 9

nausea, vomiting, anorexia, weight gain, chloasma, hypertension, decreased glucose tolerance, thromboembolism, cancer growth (breast, uterine but does not cause them), migraine headache (increased risk of stroke), GERD

Front 10

Uses for estrogen drugs

Back 10

failure of ovarian development, menopause (HRT)--in combo with progestin if still have uterus, osteoporosis but bisphosphonates are preferred, dysmenorrhea, oral contraception

Front 11

Raloxifene MOA

Back 11

estrogen agonist in bone, antagonist in breast and endometrium

Front 12

Raloxifene uses

Back 12

osteoporosis, reduce breast cancer risk

Front 13

Raloxifene side effects

Back 13

hot flashes, leg cramps, increased incidence of venous thrombeombolism

Front 14

Tamoxifen MOA

Back 14

Pro durg, blocks estrogen in breast tissue, agonist in bone, liver, and endometrium (may increase uterine cancer but benefit outweighs risk)

Front 15

Tamoxifen use

Back 15

inhibition of growth of estrogen dependent breast tumors. Can get resistance only use for 5 yrs

Front 16

Clomiphene

Back 16

strogen receptor antagonist

Front 17

Clomiphene MOA

Back 17

decreases signal of estrogen to the hypothalamus so there is increase in the release of GnRH and which leads to increase in LH and FSH

Front 18

Clomiphene uses

Back 18

infertility, fibrocystic breast disease

Front 19

Fulvestrant

Back 19

E2 receptor antagonist used to treat metastatic breast cancer

Front 20

Anastrozole, Letrozole, Exemestan

Back 20

block the actions or production of estrogen

Front 21

Anastrozole, Letrozole, Exemestan MOA

Back 21

decrease estrogen synthesis by inhibiting aromaste enzyme

Front 22

Anastrozole, Letrozole, Exemestan uses

Back 22

breast cancer, decrease risk of endometrium cancer, increases risk of osteoporosis

Front 23

Danazol MOA

Back 23

suppresses LH and FSH which decreases estrogen and progesterone

Front 24

Danazol uses

Back 24

endometriosis

Front 25

Medroxyprogesterone acetate administration

Back 25

IM, PO

Front 26

Medroxyprogesterone acetate uses

Back 26

dysfunctional uterine bleeding, dysmenorrhea (in combo with estrogen), edometriosis, edometrial carcinoma, oral contraception

Front 27

Medroxyprogesterone acetate

Back 27

Progestin

Front 28

Medroxyprogesterone acetate adverse effects

Back 28

weight gain, camps, acne, pigmentation changes, drowsiness, and depression

Front 29

Mifepristone

Back 29

progesterone antagonist

Front 30

Mifepristone uses

Back 30

used to terminate early pregnancy