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49 Cards in this Set

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  • Back
Ichthyosis vulgaris
X-linked ichytosis
Photoaging due to UVA
Initial redness from UVA, not a true sunburn  vasodilation of blood vessels
6-24 hrs later, UVB induced sunburn peaks
DNA is the chromophore for UVB in the keratinocytes, leading to cell death (sunburn cells) and mild inflammation
Solar elastosis (Photoaging)
Cutis rhomboidalis nuchae
Solar lentigo & freckles
Poikiloderma of Civatte (Photoaging on lateral sides of neck)
Photoreactive agents in plants are psoralens known as furocoumarins

Plants and fruits:
Carrots, celery, dill, figs, lemons, limes, parsley, and parsnips
ὑπέρ τοῦ
on behalf of; for the sake of
Polymorphous Light Eruption
Reaction to UVR in an otherwise healthy person
Etiology unclear, thought to be a delayed hypersensitivity
Most common photodermatosis - “sun poisoning”
Onset before 30 years old
Female to male ratio is 3:1
Most common in fair skinned individuals
Spring time
Xeroderma Pigmentosum
Mutation in DNA repair enzymes
Skin symptoms noted at 1-2 years old
Accelerated signs of photoaging and skin cancer
Lamellar ichthyosis
Collodian baby seen in Lamellar ichthyosis
Lamellar ichthyosis
Lamellar ichthyosis
Lamellar ichthyosis
Epidermolytic hyperkeratosis
Pseudoxanthoma elasticum
Dermato-fibroma-sarcoma protuberans
Low grade malignant proliferation of fibroblasts
Wide local excision
Pretibial myxedema
Pemphigus vulgaris
Intercellular antibodies against
Desmoglein 1
Desmoglein 3
Pemphigus vulgaris
Pemphigus foliaceus
Paraneoplastic pemphigus
Associated with:
NHL (42%)
CLL (29%)
Mucosal involvement most classic
Can have varied clinical picture
Generates auto-antibodies to skin because of a neoplasia somewhere, leading to blister of mucosa and skin
Mucous membrane pemphigoid or cicatricial (scarring) pemphigoid
Scarring, blindness risk
Oral (90%)
Conjunctival (66%):
Cutaneous (25%)
Middle-aged women
Little tendency toward remission
Tx: Cyclophosphamide
Gestational pemphigoid
Also called in the past “Herpes gestationis”
Pruritic urticarial (hive like) wheals on the trunk
Onset: 2nd or 3rd trimester or immediate postpartum
Epidermolysis bullosa simplex
Intraepidermal blister
Localized type: palms and soles
Generalized type: skin, mucosa, and nails
problem with the keratin filaments-5 and 14 (absence or dysfunction) that leads to poor adhesion properties and cleavage of the skin at the basal keratinocyte. This results in a bulla, usually in times of heat, and at areas of friction.
Dystrophic Epidermolysis bullosa (Recessive q slide, Dominant a slide)
Blister in sublamina densa
Mutation in collagen VII
Longitudinal melanonychia
Proximal Subungual Onychomycosis
Distal Subungual Onychomycosis
Hutchinson's Sign
Beau's Lines
Aldrich-Mee's Line
Periungual telangietasia
Half & Half nails
Yellow Nail Syndrome
Telogen Effluvium
Alopecia Areata
Alopecia areata