Dermatology Disorder Pictures

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Ichthyosis vulgaris

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X-linked ichytosis

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Photoaging due to UVA

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Initial redness from UVA, not a true sunburn  vasodilation of blood vessels
6-24 hrs later, UVB induced sunburn peaks
DNA is the chromophore for UVB in the keratinocytes, leading to cell death (sunburn cells) and mild inflammation

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Solar elastosis (Photoaging)

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Cutis rhomboidalis nuchae
(Photoaging)

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Solar lentigo & freckles
(Photoaging)

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Favre-Racouchot
(Photoaging)

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Poikiloderma of Civatte (Photoaging on lateral sides of neck)

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Phytophotodermatitis
Photoreactive agents in plants are psoralens known as furocoumarins

Plants and fruits:
Carrots, celery, dill, figs, lemons, limes, parsley, and parsnips

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ὑπέρ τοῦ

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on behalf of; for the sake of

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Polymorphous Light Eruption
Reaction to UVR in an otherwise healthy person
Etiology unclear, thought to be a delayed hypersensitivity
Most common photodermatosis - “sun poisoning”
Onset before 30 years old
Female to male ratio is 3:1
Most common in fair skinned individuals
Spring time

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Xeroderma Pigmentosum
AR
Mutation in DNA repair enzymes
Skin symptoms noted at 1-2 years old
Accelerated signs of photoaging and skin cancer

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Lamellar ichthyosis

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Collodian baby seen in Lamellar ichthyosis

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Lamellar ichthyosis

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Lamellar ichthyosis

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Lamellar ichthyosis

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Epidermolytic hyperkeratosis

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Pseudoxanthoma elasticum

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Keloids

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Dermato-fibroma-sarcoma protuberans
Low grade malignant proliferation of fibroblasts
Wide local excision

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Morphea

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Pretibial myxedema

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Pemphigus vulgaris
Intercellular antibodies against
Desmoglein 1
Desmoglein 3

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Pemphigus vulgaris

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Pemphigus foliaceus

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Paraneoplastic pemphigus
Associated with:
NHL (42%)
CLL (29%)
Mucosal involvement most classic
Can have varied clinical picture
Generates auto-antibodies to skin because of a neoplasia somewhere, leading to blister of mucosa and skin

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Mucous membrane pemphigoidor cicatricial (scarring) pemphigoid
Scarring, blindness risk
Involvement:
Oral (90%)
Conjunctival (66%):
Cutaneous (25%)
Middle-aged women
Little tendency toward remission
Tx: Cyclophosphamide

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Gestational pemphigoid
Also called in the past “Herpes gestationis”
Pruritic urticarial (hive like) wheals on the trunk
Onset: 2nd or 3rd trimester or immediate postpartum

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Epidermolysis bullosa simplex
Intraepidermal blister
Localized type: palms and soles
Generalized type: skin, mucosa, and nails
problem with the keratin filaments-5 and 14 (absence or dysfunction) that leads to poor adhesion properties and cleavage of the skin at the basal keratinocyte. This results in a bulla, usually in times of heat, and at areas of friction.

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Dystrophic Epidermolysis bullosa (Recessive q slide, Dominant a slide)
Blister in sublamina densa
Mutation in collagen VII

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Longitudinal melanonychia

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Melanoma

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Proximal Subungual Onychomycosis

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Distal Subungual Onychomycosis

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Hutchinson's Sign

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Beau's Lines

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Aldrich-Mee's Line

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Periungual telangietasia

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Half & Half nails

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Yellow Nail Syndrome

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Psoriasis

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Telogen Effluvium

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Alopecia Areata

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Alopecia areata