Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
T or F: hodgkin's lymphoma is more common than non-hodgkins.
|
false; non-hodgkins is more common
|
|
what is the most common age group affected by NHL?
|
> 50 years old
|
|
what is the most common age group affect by hodkin's lymphoma?
|
bimodal distribution with peaks at 20 and 65
the majority of the cases however are of young adults |
|
what are the four infectious agents associated with NHL and what specific type of NHL are they associated with?
|
- H. pylori = gastric MALT NHL
- EBV = Burkitt's lymphoma - Hepatitis C = Indolent NHL - HTLV 1 = Adult T cell leukemia/lymphoma |
|
what order should you perform lab studies in when trying to diagnose lymphoma?
|
- CBC
- Liver function test - renal failure test - LDH - B2 microglobin - Albumin - Uric acid - Alkaline phosphatase |
|
T or F: when doing a lymph node biopsy for lymphoma it is ok to just do an aspirate.
|
false, you need to biopsy the entire node
|
|
T or F: when doing a bone marrow biopsy for lymphoma you need to biopsy both hips.
|
true
|
|
Ann Arbor Stage I for NHL
|
involvement of a single lymph node region
|
|
Ann Arbor Stage II for NHL
|
more than 2 lymph node regions on the same side of the diaphragm
|
|
Ann Arbor Stage III for NHL
|
lymph nodes on both sides of the diaphragm including the spleen
|
|
Ann Arbor Stage IV for NHL
|
multifocal involvement of more than 1 extralymphatic site
|
|
what are B symptoms?
|
constitutional symptoms that may or may not be seen in NHL
specifically these include temp > 38 C, night sweats, and > 10% weight loss |
|
list the factors in the IPI score.
|
- age
- LDH - performance status - Extranodal involvement - Stage |
|
what is the IPI score used for?
|
to determine a prognosis for diffuse large B cell lymphoma
|
|
what is CHOP?
|
the standard chemotherapy used when treating diffuse large B cell lymphoma. it includes:
- Cytoxan (cyclophosphamide) - Hydroxydaunomycin - Oncovin (vincristine) - prednisone |
|
what is the major side effect of Rituximab?
|
it may cause reactivation of Hep B virus
|
|
what are the low grade NHLs?
|
follicular lymphoma
small lymphocytic lymphoma |
|
what age group is usually affected by low grade NHLs?
|
patients are usually > 65 years old
|
|
what is the prognosis for low grade NHLs?
|
these are incurable and often transform into aggressive histology with a median survival of less than 1 year
|
|
what are the high grade lymphomas?
|
- large immunoblastic
- lymphoblastic - Burkitts - Non-Burkitts - PTLD - HIV associated |
|
what is tumor lysis syndrome?
|
when massive amounts of tumor cells lyse (due to treatment) they release potassium and uric acid. this can lead to renal failure and hypocalcemia
|
|
what is the cause of MALT lymphoma of the gastric mucosa?
|
helicobacter pylori infection
|
|
how do you treat MALT lymphoma of the gastric mucosa?
|
triple therapy
- PPI - Amoxicillin - Clarithromycin eradication of H. pylori usually induces remission |
|
what are Reed-Sternberg cells diagnostic for?
|
Hodgkin's lymphoma
|
|
what are the prognostic factors for Hodgkin's lymphoma?
|
- age
-gender - stage - albumin - hemoglobin - WBC - lymphocytes |
|
how do we treat Hodgkin's lymphoma?
|
ABVD
- adriamycin - bleomycin - vinblastine - decarbazine |