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28 Cards in this Set
- Front
- Back
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Define Cholinomimetic
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Having action similar to ACh
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What do most direct cholinomimetic agonist drugs have in their name?
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"chol"
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Name the 4 direct cholinomimetic agonist drugs
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Bethanechol, Carbachol, Pilocarpine, Methacholine
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What are the actions of Bethanecol?
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Activates bowel and bladder sm mm
"Bethany call me, maybe, if you want to activate your bowels and bladder" |
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What are the uses for Bethanecol?
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Post-op ileus, neurogenic ileus, urinary retention
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What is the action of Carbachol?
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Exactly the same as ACh
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What are the uses for Carbachol?
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Glaucoma, pupillary contraction, relief of intraocular pressure
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What is the action of Pilocarpine?
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Contracts ciliary mm of the eye and pupillary sphincter
"You cry, drool, and sweat on your pillow" |
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What are the uses for Pilocarpine?
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Potent stimulator of sweat, tears and saliva
Open + closed-angle glaucoma |
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What is the action of Methacholine?
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Stimulates muscarinic receptors of airway when inhaled
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What is the uses for Methacholine?
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Diagnostic challenge test for asthma
*NEVER used for treatment |
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What do most indirect cholinomimetic agonists have in their name?
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"stigmine"
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What do indirect cholinomimetic agonists target?
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They are anti-acetylcholinesterase drugs
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Name the 5 indirect cholinomimetic agonist drugs
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Neostigmine, Pyridostigmine, Edrophonium, Physostigmine, Donepezil
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What is the action of Neostigmine?
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Increases endogenous ACh
"Neo CNS = No CNS penetration" "Wake up, Neo" |
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What is the use for Neostigmine?
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Reversal of the NMJ blockade post-op
Post-op and neurogenic ileus, urinary retention, myasthenia gravis |
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What is the action of Pyridostigmine?
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Increases endogenous ACh
"Pyrid gets RID of myasthenia gravis" |
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What is the use for Pyridostigmine?
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Long acting treatment for Myasthenia Gravis, doesn't penetrate the CNS
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What is the action of Edrophonium?
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Increases endogenous ACh
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What is the other name for Edrophonium?
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Tensilon
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What is the use for Edrophonium?
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Short acting, used for diagnosis of Myasthenia Gravis
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What is the action of Physostigmine?
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Increase endogenous ACh
"Physo phyxes atropine OD" |
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What is the use for Physostigmine?
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Anticholinergic toxicity
CROSSES the BBB --> CNS |
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What is the Action of Donepezil?
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Increases endogenous ACh
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What is the use for Donepezil?
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Treatment for Alzheimers Disease
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What other 2 drugs increase ACh in the brain in Alzheimer's cases?
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Galantamine and Rivastigmine
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What drug reverses the symptoms of organophosphate poisoning?
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Atropine
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What drug regenerates the AChE after organophosphate poisoning?
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Pralidoxine
*GIVE ASAP |
