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51 Cards in this Set
- Front
- Back
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Draw Mannose
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Draw cellulobiose
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Draw galactose
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Draw maltose
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Draw ribose
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Draw fructose
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Draw sucrose
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Draw xulose
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Draw ribulose
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What is the difference between isomerase and epimerase?
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How does ribose-5-P for AMP?
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Converting to PRPP then adding adenine
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Draw inverting/retaining glycosidase.
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How big are the retaining and inverting distances?
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Retaining - 5
Inverting - 10.4 |
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What are the x- and y-axis intercepts on the inhibitor graphs?
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X-intercept: -1/kappm
Y-intercept: 1/vm |
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What is the formula or kappm?
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kmapp = km (1+[I]/ki)
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Draw Mannose
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Draw cellulobiose
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Draw galactose
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Draw maltose
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.
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Draw ribose
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Draw fructose
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Draw sucrose
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Draw xulose
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Draw ribulose
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What is the difference between isomerase and epimerase?
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How does ribose-5-P for AMP?
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Converting to PRPP then adding adenine
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Draw inverting/retaining glycosidase.
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.
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How big are the retaining and inverting distances?
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Retaining - 5
Inverting - 10.4 |
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What are the x- and y-axis intercepts on the inhibitor graphs?
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X-intercept: -1/kappm
Y-intercept: 1/vm |
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What is the formula or kappm?
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kmapp = km (1+[I]/ki)
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What is the formula for ki?
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ki = koff/kon
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Draw the mechanism for Asp protease.
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What happens at the very end of Asp protease?
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Proton transfer to make the free Nh2 into NH3+
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Why are proteins kinetically stable nd thermodynamically unstable?
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Amide bonds conjugate; thermodynamically unstable, because keq favors amide bond cleavage.
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Draw Zn2+ protease.
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Draw zymogen cleavage.
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What inhibits metalloprotease?
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De-hydroxylated carboxylic acid
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What inhibits Asp protease?
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Hydroxyl
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What inhibits serine/threonin?
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Boron
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What inhibits the serine/cysteine protease?
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Aldehyde
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What do you have to do before you push electrons down to a carbonyl?
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Replace carbonyl with aldehyde.
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What does the KSP question always start wtih?
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AT and ACP
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What ar ethe units for NPRs?
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C A PCP E MT TE
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What are the NPRS commands for?
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Themselves, not the ones in front of it; therefore, the one before is always a carbonyl
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Draw geranyl
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Why are E energetically important?
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They have ester links which store E; have negative charges to keep negative charges away from ester to prevent hydrolysis
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What is disaccharide formation sometimes coupled with? Draw the mechanism.
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UTP
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Describe the effects on Kmapp and Vm for competitive inhibition.
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Inhibitor competes, so it would make Kmapp vary; Vm the same, because substrate at its max can always out-compete [I]
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What type of TE cuts it off with water?
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Hydrolase
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What enzyme do statins inhibit? Draw the step they intervene with.
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HMG Coa reductase, which triggers HMG-CoA to melavonate (the RDS in cholesterol synthesis)
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Draw serine protease
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