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26 Cards in this Set

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Stomach bacterium that causes peptic ulcer
Helicobacter pylori
drugs that neutralize or reduce the acidity of stomach and duodenal contents by combining with HCl and increasing the pH of the stomach acid.
Antacids
particularly important in the treatment of Helicobacter pylori infection in patients with active duodenal ulcers.
Proton pump inhibitors
believed to cause a type of chronic gastritis and some peptic and duodenal ulcers as well.
H. pyloriare
facilitate emptying of stomach contents into the small intestine and are used both as ulcer treatments and as antiemetics.
GI stimulants
What drug class has •Actions:

–Neutralize or reduce acidity of stomach and duodenal contents by combining with HCl and increasing the pH of the stomach acid
Acid Neutralizers: Antacids
Acid Neutralizers: Used in treatment of


hyperacidity caused by: –Heartburn, acid indigestion, sour stomach, gastroesophageal reflux disease, peptic ulcer
Calcium-containing antacids: Contraindicated in patients with
renal calculi or hypercalcemia
Acid Neutralizers: Antacids: Interactant drugs
Digoxin, Tetracyclin, Corticosteroids, Salicylate, Quinidine
What drug class has Actions:

–Inhibit the action of histamine at H2 receptor cells of the stomach, which then reduces the secretion of gastric acid
Histamine H2 Antagonists
Histamine H2 Antagonists Used in treatment of: –
Heartburn, acid indigestion, sour stomach, GERD, gastric ulcer, gastric hypersecretory conditions
Histamine H2 Antagonists Adverse reactions :
Dizziness, somnolence, headache–
Confusion, hallucinations, diarrhea, and reversible impotence
Histamine H2 Antagonists: Contraindications and Precautions
cautiously in patients with renal or hepatic impairment and in severely ill, elderly, or debilitated patients: Used with caution during pregnancy and lactation
Histamine H2 Antagonists Interactant drugs
Antacids, Opioid analgesics, Oral anticoagulants, Digoxin
What drug class has Action:

Suppress gastric acid secretion by inhibition of hydrogen-potassium adenosine triphosphatase enzyme system of the gastric parietal cells
Proton Pump Inhibitors
Proton Pump Inhibitors Used in treatment of:
gastric and duodenal ulcers, GERD and erosive esophagitis, pathologic hypersecretory conditions
Proton Pump Inhibitors Adverse reactions
Headache, nausea, diarrhea, abdominal pain
Proton Pump Inhibitors: Contraindications and Precautions
Used cautiously in older adults and in patients with hepatic impairment : Contraindicated during pregnancy and lactation
Proton Pump Inhibitors Interactant drugs
Clarithromycin, Benzodiazepines, Digoxin, Oral anticoagulants, ampicillin, Sucralfate
Reduces gastric motility and decreases the amount of acid secreted by the stomach
Cholinergic blocking drugs
Binds with protein molecules to form a viscous substance which buffers acid and protects the mucosal lining
Pepsin inhibitor
Reduces the risk of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in high risk patients
Prostaglandin drug
Gastrointestinal Stimulants Actions:
Increase the motility of the upper GI tract without increasing the production of secretions
Gastrointestinal Stimulants Used in treatment of
GERD, gastric stasis
Gastrointestinal Stimulants : Higher doses or prolonged administration:
Produce central nervous system (CNS) symptoms
Dexpanthenol administration: Causes
itching, difficulty breathing, and urticaria