Ch.12 Goljan Wbc Disorder

Front 1

What are the risk factors for Leukemias?

Back 1

1. Chromsomal Abnormalitis ( Down, X'some instability)
2. Ionizing Radiation
3. Chemicals Benzene
4. Alkylating agents, Busulfan

Front 2

What are the clinical findings in acute leukemias?

Back 2

1. Abrupt onset of signs and symp
2. Fever, ( infection), bleeding ( thrombocytopenia), fatigue ( anemia),
3. Mestatic Disease:
Hepatosplenomegaly
Gneralized lymp
CNS involvement ***ALL usually
Skin involvement ( T-cell lekemias)
4. Bone pain and tenderness

Front 3

What are Lab findings in Acute leukemias?
WBC
Anemia
Platelets
Bone Marrow

Back 3

1.WBC 10,000-100,000/uL
--Blast cells usually >20%
2. Normocytic to Macro
---Based on Cell Turnover if folate is depleted
3. Thromobocytopenia < 100,000
4. Bone Marrow:
--Hypercellular with more than 20% blast ( myeloblast or lympoblast)

Front 4

How do you differentiate acute vs chronic?

Back 4

Bone marrow aspirate with blast count
Chronic < 10%
Acute > 20%

Front 5

What are the clinical findings of Chronic Leukemias?

Back 5

1. Slow onset
2. Hepatosplenomegaly and generalized lymphadenopathy

Front 6

What are the Clinical Findings of Chronic Leukemias?
WBC
ANemia
Platelet Count
Bone Marrow

Back 6

WBC:
a. Similar to Acute
b. Blast cells <10%
c.Mature cells are present
2.Normocytic to Macrocytic
---Folate depletion
3. Thrombocytopenia < 100,000
4. Bone Marrow: Hypercellular < 10% blast

Front 7

What chronic leukemia would you have thrombocytosis?

Back 7

CML occurs in ~ 40%

Front 8

What is the most important test for diagnosing leukemia?

Back 8

Bone Marrow Examination

Front 9

What cytogenetic abnormalities are common in AML?

Back 9

t15:17 = acute promyelocytic leukemia M3

Front 10

What class would you first see Auer Rods?

Back 10

M3= Acute Promyelocytic

Front 11

What are the risk factors for Leukemias?

Back 11

1. Chromsomal Abnormalitis ( Down, X'some instability)
2. Ionizing Radiation
3. Chemicals Benzene
4. Alkylating agents, Busulfan

Front 12

What are the clinical findings in acute leukemias?

Back 12

1. Abrupt onset of signs and symp
2. Fever, ( infection), bleeding ( thrombocytopenia), fatigue ( anemia),
3. Mestatic Disease:
Hepatosplenomegaly
Gneralized lymp
CNS involvement ***ALL usually
Skin involvement ( T-cell lekemias)
4. Bone pain and tenderness

Front 13

What are Lab findings in Acute leukemias?
WBC
Anemia
Platelets
Bone Marrow

Back 13

1.WBC 10,000-100,000/uL
--Blast cells usually >20%
2. Normocytic to Macro
---Based on Cell Turnover if folate is depleted
3. Thromobocytopenia < 100,000
4. Bone Marrow:
--Hypercellular with more than 20% blast ( myeloblast or lympoblast)

Front 14

How do you differentiate acute vs chronic?

Back 14

Bone marrow aspirate with blast count
Chronic < 10%
Acute > 20%

Front 15

What are the clinical findings of Chronic Leukemias?

Back 15

1. Slow onset
2. Hepatosplenomegaly and generalized lymphadenopathy

Front 16

What are the Clinical Findings of Chronic Leukemias?
WBC
ANemia
Platelet Count
Bone Marrow

Back 16

WBC:
a. Similar to Acute
b. Blast cells <10%
c.Mature cells are present
2.Normocytic to Macrocytic
---Folate depletion
3. Thrombocytopenia < 100,000
4. Bone Marrow: Hypercellular < 10% blast

Front 17

What chronic leukemia would you have thrombocytosis?

Back 17

CML occurs in ~ 40%

Front 18

What is the most important test for diagnosing leukemia?

Back 18

Bone Marrow Examination

Front 19

What cytogenetic abnormalities are common in AML?

Back 19

t15:17 = acute promyelocytic leukemia M3

Front 20

What class would you first see Auer Rods?

Back 20

M3= Acute Promyelocytic

Front 21

What are the risk factors for Leukemias?

Back 21

1. Chromsomal Abnormalitis ( Down, X'some instability)
2. Ionizing Radiation
3. Chemicals Benzene
4. Alkylating agents, Busulfan

Front 22

What are the clinical findings in acute leukemias?

Back 22

1. Abrupt onset of signs and symp
2. Fever, ( infection), bleeding ( thrombocytopenia), fatigue ( anemia),
3. Mestatic Disease:
Hepatosplenomegaly
Gneralized lymp
CNS involvement ***ALL usually
Skin involvement ( T-cell lekemias)
4. Bone pain and tenderness

Front 23

What are Lab findings in Acute leukemias?
WBC
Anemia
Platelets
Bone Marrow

Back 23

1.WBC 10,000-100,000/uL
--Blast cells usually >20%
2. Normocytic to Macro
---Based on Cell Turnover if folate is depleted
3. Thromobocytopenia < 100,000
4. Bone Marrow:
--Hypercellular with more than 20% blast ( myeloblast or lympoblast)

Front 24

How do you differentiate acute vs chronic?

Back 24

Bone marrow aspirate with blast count
Chronic < 10%
Acute > 20%

Front 25

What are the clinical findings of Chronic Leukemias?

Back 25

1. Slow onset
2. Hepatosplenomegaly and generalized lymphadenopathy

Front 26

What are the Clinical Findings of Chronic Leukemias?
WBC
ANemia
Platelet Count
Bone Marrow

Back 26

WBC:
a. Similar to Acute
b. Blast cells <10%
c.Mature cells are present
2.Normocytic to Macrocytic
---Folate depletion
3. Thrombocytopenia < 100,000
4. Bone Marrow: Hypercellular < 10% blast

Front 27

What chronic leukemia would you have thrombocytosis?

Back 27

CML occurs in ~ 40%

Front 28

What is the most important test for diagnosing leukemia?

Back 28

Bone Marrow Examination

Front 29

What cytogenetic abnormalities are common in AML?

Back 29

t15:17 = acute promyelocytic leukemia M3

Front 30

What class would you first see Auer Rods?

Back 30

M3= Acute Promyelocytic

Front 31

What is in Auer Rod?

Back 31

Splinter shaped to rod-shaped in cytosol
---Fused azurophilic granules

Front 32

When do you find Auer Rods?

Back 32

Only present in AML stages M2 and M3

Front 33

What is the most common type of AML, class please?

Back 33

M2: AML with maturation
30-40%
15-59 age group

Front 34

When do you see abnormal retiniotic acid metabolism? TX?

Back 34

M3: Acute Promyelocytic
TX: High Doses of Vitamin A

Front 35

What stage do you see Gum infiltration?

Back 35

M5: Acute Myelomonocytic

Front 36

What stage has increased incidence in Down's syndrome?

Back 36

M7: Acute Megakaryotic