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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Synthetic Antibacterial Drugs |
1. Sulfonamides (sulfa) & Trimethroprim -inhibit a nucleotide synthesis pathway -competitive protein inhibition
2. Isoniazid (INH) -inhibits mycolic acid in acid fast cell wall -used primarily as 1st line defense Mycobacterium tuberculosis
3. Quinolones (Ciprofloxacin) -inhibits DNA gyrase used in DNA replication -newer drug, not much resistance yet -effective against G+ & G-
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STIQ |
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AA (Antibacterial Antibiotics) Cell Wall Inhibitors |
1. Penicillin -G+ staphylococcus and strepthococcus, some G+ spirochetes -B-lactase: enzyme that breaks B-lactam ring in penicillin 2. Semisynthetic Penicillin -broader spectrum than penicillin -still has B-lactam ring -combine with Clavulanate to inhibit 3. Cephalosporin -similar to penicillins but broader spectrum -1st gen were G+, later generations treated G+ and G- equally -more resistant to B-lactamase 4. Vancomycin -drug of last resort; highly toxic: kidney and liver monitered -used primarily against highly resistant Staphylococcus infections (MRSA) and TB
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PSCV |
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Antibacterial Antibiotic Protein synthesis inhibitors |
1. Streptomycin -older antibiotic, fairly toxic -last resort against G- and TB -neomycin: topical variant
2. Tetracycline -VERY broad, highly toxic -G+, G-, & intracellular pathogens -Doxycycline commonly prescribed for acne, STDs, and prophylactic for malaria
3. Chloramphenicol -broad spectrum (G+ & G-), highly toxic: aplastic anemia - topical use only
4. Erythromycin -narrow spectrum, mostly G+ -macrocyclic ring |
STCE |
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AA Nucleic acid synthesis inhibition |
1. Rifampin -G+ & G-, fairly broad spectrum -not super common -side effect: red/orange body fluid secretion |
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Antifungals |
1. Amphotericin B -cell (plasma) membrane inhibition *polyene ring disrupts ergosterol -fairly toxic, mostly used for systemic fungal infections 2. Imidazoles -cell membrane inhibition -topical use for cutaneous fungal infections 3. Griseofulvin -inhibits mitosis by targeting microtubule formation -targets keratinized tissues only -used for under the nail fungal infections
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AIG |
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Antivirals |
1. Acyclovir -inhibit viral DNA replication -used against herpes family of viruses 2. Reverse transcription inhibitors -nucleotide analog -toxic in high doses *anti hiv drug; 2 & 3 used together (HAART) to reduce HIV replication 3. Protease inhibitors -inhibits last step of HIV maturation *anti hiv drug; 2 & 3 used together (HAART) to reduce HIV replication |
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Antiprotozoan drugs |
1. Quinine Derivatives -antimalarials -chloroquine -mefloquine -MOA: toxin build up 2. Metronidazole (flagyl) -interferes with anaerobic metabolism -used against Trichomonas (intestinal protozoan); also wprks against Clostridium infections |
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Anti-helminth drugs |
1. Mebendazol (vermox) -inhibits microtubules; motility -used for intestinal worms like Ascaris and pinworms 2. Niclosamide -inhibits aerobic respiration -used for tapeworms 3. Pyantel pamoate (antiminth) -causes paralysis of worms -used for hookworms, pinworm, Ascaris |
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Antibiotics MOA |
1. Cell Wall Inhibitors: Penicillin, Amoxicillin/Clavulanate, Vancomycin 2. Protein Synthesis Inhibitors: Doxycycline, Erythromycin, Chloramphenicol 3. Nucleic Acid Synthesis Inhibitors: Ciproflaxin 4. Antimetabolite: Sulfamethoxazole/Trimethoprim |
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