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29 Cards in this Set

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Cyclooxygenase inhibitor


inhibits expression of transcription factor NFkB which plays a key role in transcription of genes for inflammatory mediators.

acts by irreversibly inactivating both Cox 1 and Cox 2

side effects: dyspepsia, nausea vomiting other GI effects.

therapeutic doses: some GI bleeding

large: dizziness, deafness, tinnitus

toxic doses: encephalitis in children (reyes) and uncompendated metabolic

used for: cardiovascular conditions because it has the ability to inhibit platelet aggregation

short term use as an analgesic


Cyclooxygenase inhibitor


moderately cox-2 selective

side effects : GI effects and inhibition of cox-2 can lead hypertension

clinical use: RA, OA, AS and H+M


Cyclooxygenase inhibitor


weekly cox-2 selective with moderate potency

side effects: in addition of cox-2 can lead to hypertension

Uses: RA, OA, G, MS, PO


Cyclooxygenase inhibitor


very Cox 2 selective

side effects: inhibition of cox-2 can lead to hypertension; extensively metabolized by liver with high amount of plasma protein binding

uses:RA, OA, G


Cyclooxygenase inhibitor


weekly cox-1 selective

side effects: safe for children, sold over the counter; dyspepsia nausea vomiting GI effects, can lead to intestinal damage /hemorrhaging

uses: RA, OA, MS, PO, D , H+M


Cyclooxygenase inhibitor


weak cox-1 selective

side effects: dyspepsia, nausea vomiting, other GI effects; chronic use can lead to intestinal damage and hemorrhaging

uses: RA, OA, MS, PO, D


Cyclooxygenase inhibitor


weak cox-1 selective

side effects: dyspepsia nausea vomiting, GI effects; chronic use can lead to intestinal damage and hemorrhaging

uses: RA, OA, G, MS, PO, D

Treat chronic pain and anti inflammatory


Cyclooxygenase inhibitor


weak cox-2 selective

inhibition of cox-2 can lead to hypertension

uses: treats chronic pain, RA, OA, G, MS, PO


Cyclooxygenase inhibitor


weak cox-2 selective with oxygen radical scavenging effects

side effects: can lead to hypertension

uses: RA, OA, G, MS

may aid in decrease in tissue damage


Cyclooxygenase inhibitor


uses: RA, OA , MS

Sodium Aurothiomalate

DMARD-Gold compound

side effects: skin rashes, proteinurina, thrombocytopenia and blood dycrasias

used to treat RA and JRA .. given by deep intramuscular injection and nitially at a weekly rate and then at a monthly basis


DMARD-GOLD compound

Inhibit the induction of IL-1 and TNF-alpha

side effects: skin rashes, proteinuria, thrombocytopenia and blood dycrasias

uses: given orally to treat RA and JRA if pt isnt responding to other treatments, effects developed over the course of three to four months


DMARD-GOLD antimalarial (4- aminoquinoline)

used: to treat RA and SLE when other therapies fail; effects do not appear until a month or more after the drug has been started


DMARD-folic acid antagonist (immunomodulator)

Targets inflammatory cells

side effects: dyspepsia and liver cirrhosis

uses: common first choice for treating RA and OD because it has a rapid onset compared to other DMARDs and superior efficacy and less unwanted effects

First choice job can also be used in Crohn's disease and cancer treatments



inhibits both purines and pyrimidines synthesis which prevents DNA replication and reproduction

most act during the induction phase of immunological response depresses both cell mediated and antibody mediated immune reactions

uses: RA , use an iPad therapies feel and in transplant rejection


Immunosuppressant- naturally occurring in fungus

this cyclic peptide inhibits IL-2 production production or action via decreased Clonal proliferation of Tcells

can also reduce induction, clonal proliferation of cytotoxic t cells from CD8 precursor cells

side effects: nephrotoxicity, heptotoxicity, and hypertension

uses: poorly absorbed by mouth so generally given by IV

can be given in emulsion form for treatment of MGD-restais


immunosuppressant drug- macrolide antibiotic of fungal origin

similar action to ciclosporin but with higher potency and has a different internal receptor (FKBP) complex inhibits calcineurin which ultimately reduced IL-2

Side effects: nephrotoxicity, neurotoxicity with more severe rxn than ciclosporin

can also cause GID and thrombocytopenia and hyperlipidemia

uses: organ transplant and severe atopic eczema - given orally by OV or as ointment

Mycophenolate Mofetil

immunosuppressant - semisynthetic derivative of fungal antibiotic

Converted to mycophenolic acid in the body which inhibits Inosine monophosphate dehydrogenase leading to restrain proliferation of both t & B lymphocytes

reduces the production of cytotoxic T cells

side effects: unwanted GI effects

prevents organ rejection


anticytokine drugs ( biopharmaceutical)

Prevent the rejection of transplanted solid organs by blocking the IL-2 receptor and suppressing T cell proliferation

used in transplant surgery


anticytokine -fusion protein

Forms and acts as a decoy receptor which traps TNF alpha (target) preventing it from continuing the inflammatory cascade

side effect: may cause TB and hepatitis B

uses : treatment for moderate to severe RA as well as PA, SA, PP and CD


anticytokine- monoclonal antibodies - chimeric in nature

targets TNF-ALPHA

side effects : they kill the host by compliments induced lysis

may cause TB and hepatitis B

uses: moderate to severe RA


anticytokine drug- recombinant protein

targets IL-1

side effects : may cause TB and hepatitis B

uses : moderate to severe RA



Target's receptors on leukocytes disrupting immune signaling or cell trafficking

by preventing leukocytes you prevent the production of inflammatory mediators

side effects : may cause TB and hepatitis B

uses: treatment of RA


Inhibits uric acid synthesis by non competitive inhibition of xanthine oxidase

also inhibits the formation of kidney stones

side effects : GID, allergic reactions and blood problems

uses: treatment of gout


uricosuric agent

Increasing uric acid excretion of urine by directly acting on renal tubule

side effect: cannot be taken with aspirin or salicylates as they will neutralize each other and no effect will be seen

use: treatment of gout in patients that have had reactions allopurinol


uricosuric agent

Contains enzymes and acid oxidase which degrades uric acid

oxidizes uric acid in blood to something more easily excreted



Prevents the migration of neutrophils into the joint by binding to tubulin; this results in a depolymerization of the microtubules and reduced cell ability to migrate

can also prevent the production of purative inflammatory glycoprotein by neutrophils that have phagocytosed urate crystals

inhibiting leukocyte migration to the joint

side effects: nausea vomiting abdominal pain; large doses can cause GI hemorrhaging and kidney damage

uses: useful in gout arthritis and used to prevent acute attacks



Inhibits multiple anti inflammatory cytokines

alternative to an NSAID to treat acute gout


NSAID - potent analgesic, antipyretic..WEAK anti -inflammatory

inhibits CNS COX isoform

is converted to N- acetyl-p- benzoquinone imine

side effects: once converted can react with cell proteins and can kill the cell--potentially fatal by liver damage