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39 Cards in this Set
- Front
- Back
Idiopathic thrombocytopenic purpura - caused by..?
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Antibodies against platelets, splenic destruction of opsonized platelets, usually following a viral upper respiratory tract infection
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This enzyme is active during VDJ rearrangement in lymphocytes....marker of primitive cells in cancer?
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Terminal deoxynucleotidyl transferase
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Cytoplasmic mu chain expression indicates that a lymphocyte has undergone...?
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VDJ rearrangement
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Describe MCV, MCH, and MCHC of B12 anemia?
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High MCV, High MCH, and normal MCHC
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Target cells are most commonly seen in...?
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Thalassemia, hemoglobin C, and liver disease
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CLL is a disease of which age group?
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Older adults - 65
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Acute monocytic leukemia - what FAB classification?
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M5
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Hepatic chirrhosis is associated with which changes in the spleen?
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Thickened capsule and many small, scarred areas with fibrosis with hemosiderin and calcium deposition
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Which subtype of AML could lead to DIC? How?
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M3 - during tx as a cnosequence of release of granules (Auer rods) from cells in the promyelocytic line
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Crew haircut appearance of the skull is due to which conditions?
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Sickle cell anemia, thalassemia
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which translocations are associated with Burkitt lymphoma?
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8;14, 8;22, 2;8
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Stage III Hodgkins with constitutional symptoms gets staged how..?
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Stage IIIB
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Describe serum levels of iron, ferritin, and transferrin in iron deficiency anemia?
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Serum iron and ferritin is decreased, while transferrin is increased
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Translocation seen in the follicular type of small cleaved cell (B cell) lymphoma?
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14;18
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Reed Sternberg cells express which CDs?
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CD15 and CD30
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Lacunar cells are seen in which type of Hodgkin disease?
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Nodular sclerosing variant
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Which autoimmune disease is a significant cause of thyombocytopenia?
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SLE
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Acute promyelocytic leukemia is associated with which translocation?
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15;17
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This disease causes purpura, fever, renal failure, MAHA, and microthrombi, frequently in young women..?
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Thrombotic thrombocytopenic purpura
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T or F? All lympgomas are monoclonal.
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True
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Defects in platelet adhesion are seen in which diseases?
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von Willebrand's and Bernard-Souliier
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T or F? Aspirin therapy interferes with secondary platelet aggregation.
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True
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This disease produces a self-limited granulomatous response in the draining lymph nodes...can be due to pets..?
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Bartonella henselae - cat-scratch disease
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Coadministration of warfarin and which antibiotic could produce pronounced anticoagulation and hematuria?
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Clarithromycin, norfloxacin
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T or F? In both thrombasthenia and vW disease, the platelet count will be normal, although platelet function is impaired.
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True
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This agent is primarily used to treat CLL and ovarian carcinoma?
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Chlorambucil
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What type of kidney stones would be expected in a patient undergoing tx for ALL?
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Uric acid kidney stones
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What cells predominate in a blood film of an infectious mono patient?
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Reactive T cells
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Most common cause of drug-induced thrombocytopenia?
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Heparin
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Hereditary spherocytosis is associated with a defect in..?
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Structural proteins such as spectrin and ankyrin
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Relapse in plasmodium infections are due to dormant forms of the organisms called...?
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Hypnozoites
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This medication can cause sharply demarcated, erythematous, and pupuric lesions, which can progress to large hemorrhagic bullae...
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Warfarin
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Characteristics of Bartonella henselae?
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Gram-negative bacillus
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What are D-dimers?
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Fibrin split products
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Lymphatic fluid from the lateral aspect of the dorsum of the foot drains to...?
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Lymph nodes in the popliteal fossa
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Clues: One week incubation period, Eastern seaboard, and intra-erythrocyte protoza..?
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Babesia microti
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Eosinophil granules contain which protein in their crystalline cores?
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Major basic protein
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Platelet count needs to be less than ......... before generalized bleeding usually occurs?
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20,000/mm3
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Parvoviruses cause which three distinct syndromes?
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1. Fifth disease (erythema infectiosum)
2. Aplastic crisis in Sickle cell anemia, thalassemia, etc 3. Congenital infections - stillbirth, hydrops fetalis, anemia |