Allergy Fit Questions

Front 1

Name 2 mediators commonly found in this type of cell

Back 1

Tryptase, chymase, carboxypeptidase, heparin cathepsin G, IL-4, TNF-alpha

Front 2

What enzyme is present in these structures

Back 2

Lysophospholipase

Front 3

The venom of this particular flying hymenoptera is standardized for the content of what protein?

Back 3

Phospholipase A (honey bee)

Front 4

He was covered with sore boils from the sole of his foot unto his crown… What immunological abnormality did he have?

Back 4

Elevated IgE

Front 5

This disease occurs in the presence of conditions and treatments that compromise cellular immunity. There is a biphasic increase and decrease of CD1a+ Langerhans cells in the epidermis

Back 5

Norwegian Scabies

Front 6

Who are they and what did they discover?

Back 6

Teruko and Kimishige Ishizaka
IgE

Front 7

He discovered and named “mast cells”.

Back 7

Paul Ehrlich

Front 8

Which cells of the immune system are defined by metachromasia?

Back 8

Mast cells and basophils

Front 9

What is the only X-linked complement component deficiency?

Back 9

Properdin deficiency

Front 10

What colors are emitted by the following fluorochromes after excitation by the laser in flow cytometry? Fluorescein (FITC), Phycoerythrin (PE) and Peridin Chlorophyll Protein (PerCP)

Back 10

FITC:green, PE:orange, PerCP:red

Front 11

Which latex allergens are patients with spina bifida allergic to?

Back 11

Hev b 1,3,7

Front 12

What percentage of health care workers are sensitized to latex?

Back 12

Up to 50%

Front 13

Hwo many latex allergens have been described?

Back 13

10

Front 14

What is the name for moutanin cedar allergen?

Back 14

Jun a ___ (Juniperus ashei)

Front 15

Most common allergen induced immediate hypersenistivity in the Mediterrean?

Back 15

Par j 1 (weed)

Front 16

Is there cross-reactivity between cockroaches?

Back 16

Only Bla g 1 and Per a 1

Front 17

What is the name of clumps of dust where cockroach allergen collects?

Back 17

Frass

Front 18

Which cockroach allergen is related to animal danders?

Back 18

Bla g 4 (lipocalin-like protein)

Front 19

What is the basis for cross-reactivity of cockroach with mites and shrimp?

Back 19

Tropomyosins – Per a 7

Front 20

What is the level of cockroach allergen needed to sensitize? Induce disease?

Back 20

2 U/g, 8 U/g

Front 21

Where do mast cells derive their name?

Back 21

Paul Erlich thought their cytoplasmic granules where a result of phagocytosis – therefore they were call mastzellen which is from Greek root mastos (to feed)

Front 22

Who described UP? Who coined the term?

Back 22

Nettleship/Sangster

Front 23

Ragweed patients get oral allergy syndrome to what?

Back 23

The gourd family: honeydew, watermelon, cantaloupe, zucchini, and cucumber

Front 24

What is the most common cause of HP in Mexico?

Back 24

Pigeon breeders disease

Front 25

Name the 6 ACR criteria for diagnosis of Chrug-Strauss

Back 25

Asthma, eos>1500, mono(poly)neuropathy, migratory pulmonary infiltrates, paranasal sinus abnormalities, extravascular eos

Front 26

What pathophysiologic process has been implicated in Churg-Strauss syndrome?

Back 26

Impairment of CD95 ligand-mediated apoptosis

Front 27

What role does a mutation in chromosome 11q play in the pathogenesis of asthma/allergies?

Back 27

Sequence variants in the high affinity IgE receptor gene (FcRII)

Front 28

Whihch candidate gene affects severity of asthma?

Back 28

Homozygotes for Gly16 on chromosome 5q affects the 2-receptor

Front 29

Growth factor for MCt (scrolls)

Back 29

SCF (aka c-kit ligand, steel factor, or mast cell growth factor)

Front 30

Growth factor for MCtc (lattice)

Back 30

SCF (aka c-kit ligand, steel factor, or mast cell growth factor)

Front 31

Growth factor for basophil

Back 31

IL-3

Less important stimulators of growth and differentiation: GM-CSF, IL-4, IL-5, nerve growth factor (NGF)

Front 32

Growth factor for eosinophil

Back 32

IL-3
IL-5
GM-CSF

Front 33

Growth factor for neutrophil

Back 33

G-CSF
GM-CSF

Front 34

Growth factor for monocyte

Back 34

GM-CSF

Front 35

Maturation site for MCt

Back 35

Tissue (mucosal surfaces in lung and intestinal mucosa)

Front 36

Maturation site for MCtc

Back 36

Tissue (connective tissue in skin, blood vessels, and GI submucosa, synovium, and foreskin)

Front 37

Maturation site for basophil

Back 37

Bone marrow

Front 38

Maturation site for eosinophil

Back 38

Bone marrow
(half life of mature cell in blood 8-18 hrs, in tissue 2-14 days)

Front 39

Maturation site for monocyte

Back 39

Progenitors mature to monocytes in BM then released into blood. Monocytes differentiate into macrophages and dendritic cells in the tissues

Front 40

Cell products of MCt

Back 40

Tryptase
PGD2
LTC4
Chrondroitin sulfate A and E
Heparin
histamine

Front 41

Cell products of MCtc

Back 41

Tryptase, chymase, carboxypeptidase, cathepsin G
PGD2
LTC4
Chrondroitin sulfate A and E
Heparin
histamine

Front 42

Cell products of basophils

Back 42

+LTC4
+Chondroitin sulfate A
+Histamine
(Negligible tryptase, MBP, and lysophospholipase)
(No chymase, carboxypeptidase, or cathepsin G.
No PGD2)
No LTB4

Front 43

Cell products of eosinophils

Back 43

MBP (major basic protein)
ECP (eosinophilic cation protein)
EDN (eosinophil derived neurotoxin)
EPO (eos peroxidase)
Charcot leyden cystal (lysophospholipase)
LTC4

Front 44

Cell products of neutrophils

Back 44

LTB4

Front 45

Cell products of monocytes

Back 45

LTB4
LTC4

Front 46

What is the name of the cow from whom Sarah Nelmes acquired cow pox?

Back 46

Blossom

Front 47

Where does the hide of Blossom hang in commemoration?

Back 47

Blossom’s hide hangs in St. George’s hospital in London

Front 48

Name this famous figure and at least 1 accomplishment

Back 48

Who isKarl Landsteiner?Discovered human blood groups (ABO) and first demonstrated haptenization.

Front 49

Name this famous figure and accomplishment.

Back 49

Who is Jules Bordet?Discovered complement

Front 50

This diagnosis has a classic Chest X-Ray seen here

Back 50

What is Chronic Eosinophilic Pneumonia?
(photographic negative of pulmonary edema)

Front 51

Name this pollen/mold

Back 51

Ash

Front 52

This is the portion of the IgE molecule to which Xolair binds.

Back 52

The CH3 domain

Front 53

Name this pollen/mold

Back 53

Alternaria

Front 54

This spirometric finding is associated with vocal cord dysfunction.

Back 54

What is blunting of the inspiratory loop?

Front 55

Name this pollen/mold

Back 55

Maple

Front 56

Name this famous figure and accomplishment

Back 56

Who is Daniel Bovet?Synthesized the first antihistamine.

Front 57

This is the agent responsible for Enzyme/Detergent Worker’s Lung

Back 57

What is Bacillus subtilis?

Front 58

This is the most common parasite causing Loffler’s syndrome

Back 58

Ascaris lumbricoides

Front 59

This patient is likely to have an elevation in what form of tryptase?

Back 59

Alpha-tryptase

Front 60

Who is this individual and what were his accomplishments?

Back 60

Von Pirquet

Coined the term “allergy”, early studies on the immunopathogenesis of serum sickness, “TB” test

Front 61

What happened to this man in 1929?

Back 61

Von Pirquet

He and his wife died of self-administered cyanide poisoning

Front 62

What was the name of the milkmaid used in Edward Jenner's cowpox study?

Back 62

Sarah Nelmes

Front 63

Where, and in what year, was the imported fire ant introduced into the US?

Back 63

Mobile, Alabama in 1918

Front 64

Solenopsis invicta and Solenopsis richteri share common antigens except for which?

Back 64

Sol I 4 is unique.

Front 65

Name the genus of the insect inhabiting this nest

Back 65

Dolichovespula spp. (white-faced or yellow hornet)

Front 66

What is the only true hornet and what makes it unique?

Back 66

Vespa crabro; it flies at night.

Front 67

Which manifestation of this disease presents first?

Back 67

Ataxia.

Front 68

What two lab abnormalities are characteristic of Ataxia-Telangiectasia?

Back 68

Elevated AFP and CEA.

Front 69

Name the four types of non-X-linked agammaglobulinemia?

Back 69

Ig (CD79 a) defect, surrogate light chain deficiency (delta5/14.1), mu heavy chain deficiency, BLNK (SLP-65) deficiency.

Front 70

Name another cause of hyper-IgM other than CD154 deficiency and what inheritance pattern does it have?

Back 70

AID (activation induced cytidine deaminase) deficiency – autosomal recessive
OR
NEMO (nuclear factor kappa B essential modulator) deficiency - x-linked

Front 71

What condition does this patient have, and what is another name for it?

Back 71

Hyper IgE syndrome/Job’s syndrome

Front 72

What immunoglobulin classes are affected in Jobs syndrome?

Back 72

IgE and IgD (both elevated)

Front 73

What is this tree, and when does it pollinate?

Back 73

Mountain cedar (Juniperus ashei), it pollinates in the winter in South Texas.

Front 74

The ant pictured here is an import to the United States from South America.
a) Name the genus of the most notable ant native to Australia.
b) What is its common name?

Back 74

A) Myrmecia
B) Jack Jumper Ant

Front 75

Who is this and what is she now known for?

Back 75

Dr. Mary lovelass.

In the 1950s, this allergist’s original report of pure venom immunotherapy as an effective treatment for stinging hypersensitivity went largely ignored.

Front 76

P-selectin is sometimes found in endothelial cell secretory granules, examples of which are pictured here.

a) What is the name of these secretory granules?
b) What is the CD marker for P-selectin?

Back 76

Weibel-Palade bodies
CD62P

Front 77

This patient has an immunodeficiency which is sometimes called SCID with a rash and also is associated with a partial mutation in what genes?

Back 77

RAG 1 or 2

Front 78

What is the name of this clump of sloughed epithelial cells sometimes seen in the sputum of asthmatics?

Back 78

Creola Body

Front 79

Identify the immundeficiency syndrome associated with this blood smear

Back 79

Chediak Higashi Syndrome

Front 80

Name the protein constituent for the structure to the right which is frequently found in the sputum of asthmatic patients.

Back 80

Galectin 10 (The Charcot leyden crystal protein)

Front 81

Name the two individuals that described the phenomenon of anaphylaxis. Which one received the Nobel Prize for this discovery?

Back 81

Charles R. Richet and Paul J. Portier

Charles R. Richet received the Nobel Prize

Front 82

Name the venom component that is closely related between the two flying hymenoptera pictured

Back 82

Hyaluronidase

Front 83

Name the component of the imported fire ant venom that causes the sterile pustules pictured

Back 83

Piperidine alkaloid

Front 84

Name this pollen:

Back 84

Ragweed

Front 85

Name this pollen

Back 85

Alternaria

Front 86

Name this pollen

Back 86

Pine

Front 87

Name this pollen

Back 87

Mt Cedar

Front 88

Name this pollen

Back 88

Birch

Front 89

Who is this and what is he famous for?

Back 89

Sir Edward Jenner

Created first true vaccine; smallpox vaccine

Front 90

Who are they and what did they do?

Back 90

Who are Kimishige and Teruko Ishizaka?

Discovered IgE

Front 91

Before the identification of IgE this was the name given to the as yet uncharacterized antibody.

Back 91

Reagin

Front 92

This type of tryptase is released from the mast cell during anaphylaxis.

Back 92

Beta-tryptase

Front 93

The acronym RANTES stands for this.

Back 93

Regulated on Activation, Normal T-cell Expressed and Secreted

Front 94

This is the chemical precursor of histamine

Back 94

histadine

Front 95

This is the characteristic appearance of the granule matrix in mast cells that possess chymase.

Back 95

lattice (or grating)

Front 96

This is the typical cause of death in end-stage ABPA patients.

Back 96

Cor pulmonale (Heart failure)

Front 97

This is the percentage of asthma patients with a positive skin test to Aspergillus.

Back 97

25%

Front 98

Name 3 of the 4 pathologic changes found in the lungs of asthma patients.

Back 98

1. Thickened basement membrane
2. Eosinophilic infiltrate
3. Smooth mucle hypertrophy
4. Mucus gland hyperplasia

Front 99

As seen in X-linked SCID, these cytokine receptors all share a common gamma chain.

Back 99

IL-2
IL-4
IL-7
IL-9
IL-15
IL-21

Front 100

This organism is characteristically associated with the septic arthritis seen in XLA.

Back 100

Ureaplasma urealyticum

Front 101

The acronym NEMO stands for this

Back 101

NFκB essential modulator

Front 102

Name this disease

Back 102

DiGeorge Syndrome

Front 103

This disease is being assessed
AND
this patient (A-D) has the most common form.

Back 103

Chronic Granulomatous Disease
AND
Patient B(x-linked form)

Front 104

What type of pollen is this?

Back 104

Grass

Front 105

Name this pollen

Back 105

Lambs quarters (or pigweed)

Front 106

Name this pollen

Back 106

Epicoccum

Front 107

Who is this and what is he famous for?

Back 107

Leonard Noon?

Pioneered allergy immunotherapy

Front 108

Who is this and what is he famous for?

Back 108

Clemens von Pirquet

Coined the term “allergy”

Front 109

Who is this and what is he famous for?

Back 109

Charles Blackley

Pioneered the allergy skin test.

Front 110

Name this man and what he's famous for

Back 110

Nicholas-Maurice Arthus

First described the Arthus reaction

Front 111

This is another name used when referring to Hypersensitivity Pneumonitis.

Back 111

Extrinsic Allergic Alveolitis

Front 112

This activity seems to reduce a patient’s risk of developing HP

Back 112

Smoking

Front 113

This is the general name for the organisms that cause Farmer’s Lung

Back 113

thermophilic actinomycetes

Front 114

This is the agent responsible for Enzyme/Detergent Worker’s Lung

Back 114

Bacillus subtilis

Front 115

A lung biopsy in a patient with HP will usually return this pathologic description

Back 115

nonspecific interstitial pneumonitis

Front 116

Despite its efficacy,Xolair has not convincingly shown that it can affect this

Back 116

improve lung function (specifically, FEV1)

Front 117

According to the company, this is the acceptable range of IgE with which patients can be treated with Xolair

Back 117

30-700 IU/ml

Front 118

This is the formula used to calculate the dose of Xolair.

Back 118

0.016 x weight(kg) x IgE(IU/ml)?

Front 119

This was the name used by the Xolair product in research studies before it was licensed as a commercial product

Back 119

rhuMAB-E25

Front 120

This allergen is specific to the honeybee

Back 120

mellitin

Front 121

This is the common name for the major allergen found in the vespids

Back 121

antigen-5

Front 122

This is felt to be the amount of venom protein injected during an actual honeybee sting

Back 122

50mcg

Front 123

This insect is responsible for the greatest number of confirmed systemic reactions to biting insects.

Back 123

Triatoma (kissing bug)?

Front 124

Three different species are required to perform the CH50 test.

These are the species and the unique component they provide.

Back 124

1. human serum
2. sheep red blood cells
3. rabbit antibody against sheep RBC

Front 125

Who is this and what is he famous for?

Back 125

Freeman

Father of Immunotherapy

Front 126

Who is this and what is he famous for?

Back 126

Cesar Milstein

Developed monoclonal antibodies

Front 127

Who is this and what is he famous for?

Back 127

Frank M. Burnet

Clonal selection theory

Front 128

Who was this and what are they known for?

Back 128

Aretaeus

First documented description of asthma

Front 129

This sign is when stroke UP lesion and get flaring reaction.

Back 129

Darier's Sign

Front 130

What immunodeficiency may this child have?

Back 130

DiGeorge Syndrome

Front 131

This patient had WBC of 60,000. What is immunodeficiency?

Back 131

LAD

Front 132

What immunodeficiency may this individual have?

Back 132

Hyper IgE (xray showing lung abscesses)

Front 133

This finding in hair follicle (left photo) is seen in what immunodeficiency?

Back 133

Giant granule in hair of patient with Chėdiak-Higashi syndrome

Front 134

What immunodeficiency may this individual have?

Back 134

Chėdiak-Higashi syndrome

Front 135

What syndrome may this indivual have?

Back 135

Griscelli syndrome

Front 136

this patient has silver hair. What syndrome may this indivual have?

Back 136

Griscelli syndrome

Front 137

What does this person have?

Back 137

Chronic Mucocutaneous Candidiasis

Front 138

What is cytokine mediator of Schwartzman reaction (repeated local injection of LPS which causes hemorrhagic necrosis at site)?

Back 138

TNF

Front 139

They described mechanism of the type I hypersensitivity allergic reaction using an in vivo test of one persons serum (allergic to fish) injected into another’s arm followed by injection of the fish antigen at same site.

Back 139

Prausnitz and Kustner (allergic to fish)

Front 140

Who were the first two individuals to start using immunotherapy?

Back 140

Noon and Freeman

Front 141

What was the name of the ship upon which first experiments of anaphylaxis conducted?

Back 141

Princess Alice II

Front 142

What is thought to be first description of anaphylaxis in history?

Back 142

King Menses

Front 143

Who was first to describe asthma?

Back 143

Aretaeus the Cappodocian
Greek physician

Front 144

What skin disorder has histology of deposition of granular IgA at the dermal papillary tips?

What systemic disease is the skin disorder related to?

Back 144

Dermatitis herpetiformis which is associated with celiac disease

Front 145

Describe the shape of a Charcot-Leyden crystal

Back 145

Hexagonal Bipyramidal

Front 146

Birch pollen antigen, Bet v 1, is associated with an oral allergy syndrome to what fruits/vegetables?

Back 146

Apples ● Pear
Celery ● Carrot
Parsnip ● Potato
Hazelnut ● Kiwi

Front 147

Eating what kind of food can lead to symptoms in those allergic to Penicillium?

Back 147

Blue-veined cheeses
Roguefort
Camembert

Front 148

What test(s) would you use to evaluate a patient suspected of having CSF rhinorrhea?

Back 148

Glucose > 30 mg/dl
Elevated Beta2 transferrin

Front 149

What is the eponym for the syndrome characterized by cow’s milk protein induced GI blood loss, anemia, hypoproteinemia and pulmonary infiltrates in young children?

Back 149

Heiner’s syndrome

Front 150

What is most common allergen induced immediate hypersensitivity in the Mediterrean?

Back 150

Parietaria (Par j 1)

Front 151

This phenomenon is induced by esoinophil derived neurotoxin.
What is the name of this phenomenon and what are the signs / symptoms?

Back 151

Gordon Phenomenon

Ataxia, Encephalopathy, Demylenation and Purkinje cell degeneration

Front 152

What leukotriene class does neutrophils have compare to eosinophils?

Back 152

Neutrophils – LTB
Eosinophils - LTC

Front 153

Which flying hymenoptera has highest rate of infection?

Back 153

Yellow jacket since hangs around garbage

Front 154

Which foods cross react with latex?

Back 154

Avacado
Banana
Chestnut
Fig
Kiwi

Front 155

Which syndrome has recurrent episodes of pneumonia associated with:
pulmonary infiltrates
Hemosiderosis
GI blood loss
iron deficiency anemia
FTT

Back 155

Heiner’s syndrome

Front 156

Which food is most common agent involved in food-associated exercise induced anaphylaxis?

Back 156

Shellfish (also wheat, fruit, celery and fish)

Front 157

What does T.R.U.E. test stand for?

Back 157

Thin-layer Rapid Use Epi-cutaneous test

Front 158

What was first indoor allergen to be purified?

Back 158

Fel d 1

Front 159

Who was 1st person to show that live attenuated bacteria conferred specific immunity? What was the bacteria?

Back 159

Louis Pasteur
Anthrax

Front 160

Arthus reaction represents what type of Gell and Combs reaction?

Back 160

Type III hypersensitivity – local complexes

Front 161

Cause of bagassiosis

Back 161

Thermoactinomyces vulgaris
From Moldy sugarcane (bagasse)

Front 162

Cause of Wine grower's lung

Back 162

Botrytis cinerea
Moldy grapes

Front 163

Cause of Suberosis

Back 163

Penicillium frequentans
Moldy cork dust

Front 164

Name the ABPA diagnostic criteria

Back 164

Asthma (Essential)
Immediate cutaneous reactivity to A. fumigatus (E)
Elevated total serum IgE (>1000 ng/mL) (E)
Elevated serum IgE and serum IgG to A. fumigatus (E)
Precipitating serum antibodies to A. fumigatus (E)
Peripheral blood eosinophilia (> 1x109)
History of pulmonary infiltrates
Proximal bronchiectasis

Front 165

How do you convert ng/mL to IU/mL?

Back 165

Divide ng/mL by 2.4
OR
Multiply ng/ml by 0.417

1000 ng/mL = 417 IU/mL

Front 166

What is the major honeybee venom antigen?

Back 166

Phospholipase A

Front 167

What is the major vespid venom antigen?

Back 167

Antigen 5

Front 168

What is the major IFA venom antigen?

Back 168

Sol i 2

Front 169

What component of the IFA venom causes the sterile pustule?

Back 169

Piperidine alkaloids

Front 170

Which IFA venom antigen shows some limited cross-reactivity with vespid venoms?

Back 170

Sol i 1

Front 171

BY which protein are honeybee venoms standardized?

Back 171

Phospholipase A2

Front 172

BY which protein are vespid venoms standardized?

Back 172

hyaluronidase

Front 173

Which historical factors argue against discontinuing venom itx?

Back 173

Reaction to honeybee
Systemic reaction during itx
Either from itx itself or from wild sting
Initial “DRT” reaction

Front 174

Who is this and what are they famous for?

Back 174

Niels Jerne (born 1955)

He first suggested that individuals possess many clonally derived lymphocytes that develop prior to exposure to antigen and are capable of responding to a wide variety of antigens (the clonal selection hypothesis).

Front 175

Who is referred to as the Father of Occupational Medicine.

Back 175

Bernardino Ramizzini

Front 176

Who performed the first successful bone marrow transplant in the world

Back 176

Robert A. Good

Univ of Minnesota in 1968

Front 177

Who described asthma as a neurotic disease?

Back 177

Sir William Osler

Front 178

Who is this and what did he use to treat immunodeficient patients?

Back 178

Col Ogden Bruton.

He first used intramuscular injections of Cohn’s fraction II to treat immunodeficient patients.

Front 179

This tree, a native of Asia, was introduced in the US in an attempt try to start up a silk industry. What is the name of the tree?

Back 179

White Mulberry

Front 180

Which imported fire ant allergen shows up to 50% homology to vespid group 5 allergens?

Back 180

Sol i 3

Front 181

Name the muscarinic receptor that presynaptically inhibits cholinergic nerves, and its downregulation is thought to play a role in asthma.

Back 181

M2

Front 182

Name the predominant cellular infiltrate in irritant contact dermatitis

Back 182

Neutrophils