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11 Cards in this Set
- Front
- Back
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Regulation of Blood Pressure
Renin - Angiotensin- Aldosterone |
Aldosterone is secreted by the adrenal glands
Renin is secreted by kidney cells Angiotensinogen ( pre-angiotensin) is produced by the liver |
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Renin
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Juxtaglomerular cells of the kidney produce renin
Renin is an enzyme that converts angiotensinogen to angiotensin I |
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Angiotensin
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Starts as angiotensinogen - produced by the liver
Converted to angiotensin I by renin from the kidneys Angiotensin I is converted to angiotensin II in the lungs with the help of ACE (angiotensin converting enzyme) |
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Angiotensin II
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Active hormone
Stimulates the production of aldosterone by the adrenal glands Stimulates secretion of ADH Stimulates thirst and increased fluid intake Stimulates cardiac output and constrictionof arterioles, thus elevating blood pressure |
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Aldosterone
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Secretion is stimulated by angiotensin II
Secreted by the adrenal gland Secreted by the zona glomerulosa of the cortex Causes Na+ retention by the kidneys, so increases fluid reabsorption, which increases volume of blood, and increases blood pressure |
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Adrenal Glands
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Cortex
Zona glomerulosa - secretes mineralocorticoids, such as aldosterone zona fasciculata - secretes glucocorticoids, such as cortisol Zona reticularis - secretes gonadocorticoids, such as androgens as testosterone Medulla - secretes epinephruine and norepinephrine |
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Glucocorticoids
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Secreted by adrenal cortex - zona fasciculata
Cortisol is an example of glucocorticoids Secreted in response to stress |
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Renin Secretion
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Initiated by
Dehydration , Na+ deficiency or hemorrhage This causes a decrease in blood volume ; This causes a decrease in blood pressure |
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Angiotensin II
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Potent vasoconstrictor
Helps to increase blood pressure ACE inhibitors are used as treatment for high blood pressure because they stop the conversion of angiotensin I to angiotensin II |
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Aldosterone
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After filtration, reabsorbs Na+ and water to increase blood volume
Also causes an increase in K+ secretion into urine |
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Kidneys
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Filtration (blood to tubules)
Reabsorption (tubules to blood) Secretion (blood to tubules) |
