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10 Cards in this Set

  • Front
  • Back
What % of depressed elderly will feature
cognitive deficits?
How does depression affect cognition:

What is the cognitive interference hypothesis?
the cognitive interference hypothesis according to which depressive thoughts and worries interfere and disrupt performance
How does depression affect cognition:

What is the reduced motivation hypothesis?
the reduced motivation hypothesis which suggests that depressed people are insufficiently motivated to perform normally.
How does depression affect cognition:

What is the learned helplessness hypothesis?
the learned helplessness hypothesis, which states that depressed people expect that their responses will make no difference and so they give up trying
What is the alternate view to the above hypotheses?
Alternate view is that the physical effects per se disrupt cognition (e.g. neuranatomical/transmitter)
Is the cognitive interference hypothesis likely?
Cognitive interference hypothesis is unlikely as generally working memory is spared and should be
most susceptible.
Is the reduced motivation/learned helplessness hypothesis likely?
Reduced motivation/learned helplessness:
probable; (e.g. Rohling et al, 2002) ; but why
do only some feature the cognitive deficits?
Heritability of depression?

- This is much lower than the heritability of SZ (~75%)
- Partly due to heritable depressive personality traits (neuroticism)
Is MDD a single gene disease?

Some chromosomal loci of linkage have been replicated, But none has been replicated in every family study.
Possible Contributions of Neural Circuits to depression:

Orbitofrontal cortex? (3)
Depressed patients respond faster to sad words, more to negative feedback, and have smaller volumes