Ubiquitous Chemical that Emulates the Hormone Estrogen Essay

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Bisphenol A (BPA) is ubiquitous chemical that has been known to emulate the hormone estrogen and act as an endocrine disruptor (Vogel 2009). Since its development in the 1890s, BPA has been widely used in the production of plastics, PVC, food packaging, laptops, cellphones, hospital equipment, and cosmetics (Rochester 2013; Vogel 2009). It has become a topic of popular debate in the past years for its estrogen-mimicking feature and possible noxious effects, which include: miscarriage, premature delivery, altered hormone, liver, and thyroid function (Vogel 2009). The FDA declared it a “chemical of concern” in 2008 and banned its use in baby bottles and containers, yet it still considers BPA safe under current low-dose exposure (Vogel 2009). …show more content…
Most of the studies conducted have been done on rodents, and have provided evidence for low-dose BPA exposure and its correlation with obesity, liver, thyroid disfunction, miscarriage, female hormonal disbalance, breast/prostate cancer and brain abnormalities (Vogel 2009). A recent study analyzed information from the Comparative Toxicogenomics Database (CTD), a public resource with a collection of scientific data that is used to predict relationships between genes, proteins, and diseases (Comparative Toxicogenomics Database). The study revealed that BPA displays akin toxicogenomics effects that are harmful to human health; this was made evident by the interactions BPA caused between genes/proteins and cells/tissue, which showed signs of toxicity (Singh & Shoei-Lung 2011). Theses interactions manifested signs of inflammation, genital, endometrial, ovarian, and breast disease (Singh & Shoei-Lung 2011). Other studies have found that similar to the sex hormone, estradiol, BPA alters cell functions and stimulates tissue at very low concentrations proving that it is more active and potent than previously thought, although agencies like the FDA have said BPA is a weak-estrogen, that triggers estrogenic responses and binds to few estrogen-binding proteins (receptors) (Wade 2006). However, studies reveal that this may not be the case as BPA has demonstrated to have many ways to bind to estrogen receptors and

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