The Use Of Blood And Blood Forming Tissues As A Target Organ For Drugs

883 Words Sep 20th, 2016 4 Pages
First, hematotoxicity is the study of blood and blood-forming tissues as a target organ for drugs or different chemicals. It is the toxic effect that the substance has on the properties or components of blood. Additionally, other factors to include when determining toxicity are stress, exercise, and ionizing radiation. Furthermore, blood and hematopoietic tissue are target organs for scrutiny and the study in preclinical and clinical safety evaluations.
There are several methods that researchers can use when conducting tests on drugs and substances. The hematotoxicity testing will be dependent on if the drug is actively administrated to patients who had reactions or if the drug is still in the discovery phase.
A controversial issue is the predictive value of data from human preclinical safety and toxicity studies for hematotoxicity. When testing among different species, there may be similarities with some of the results. However, the metabolism and the relative sensitivity is where major differences occur. This leads to a lowering of the predictability ration in humans. The monkey is a more predictive species for humans due to the physiological make-up of the animal. It is similar to that of a human and is more predictive. Some of the hematology parameters for testing would include erythrocyte count,
The erythrocyte count determines the red blood cells circulating in the bloodstream. The erythrocyte carries the pigment that makes the reddish color of the blood due to…

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