Essay about The Pathogenesis And Clinical Symptoms Of Septic Arthritis

944 Words Oct 29th, 2016 4 Pages
It has been documented that rheumatoid arthritis in combination with medications used to prevent further damage in joint tissue, may compromise the immune system and the body’s inflammatory response. This can lead to an increased risk of infections, including septic arthritis. The woman in this case study was diagnosed with rheumatoid arthritis at the age of 37, when severe changes had already started to show. Prednisolone, a corticosteroid, was prescribed 5 years later, even though it is normally given in early development of the disease due to its anti-inflammatory effects. However, Prednisolone also works as an immunosuppressant, and may cause osteoporosis and bone loss. With an already weakened immune system, and a permeable or lack of synovial membrane as a result of the condition, bacteria can easily travel via blood into the synovial fluid, and finally lead to septic arthritis. This paper will discuss the pathogenesis and clinical symptoms of septic arthritis. It will also cover the relating processes in infection, acute inflammation and the potential for chronic inflammation.

Rheumatoid arthritis is a systemic, inflammatory autoimmune disease, which affects the synovial membrane that lines the joint cavity. The cause of rheumatoid arthritis is likely to be a combination of genetic factors interacting with inflammatory mediators. These immune reactions causes cartilage damage by (1) activating neutrophils and other cells in the synovial fluid, (2) stimulating the…

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