Stability of synthetic cathinones in biological samples
A review of literature confirms to the fact that substance abuse is a global phenomenon. The most of countries strongly prohibit use of illicit drugs. For this reason, the people who are addicted for to illicit drugs are now addicted to new active substances which are called legal highs . These substances are more freely available and they can produce similar effects to illicit drugs [1,2].
Synthetic cathinones are one of the important psychoactive substances groups and they are synthetic derivatives of cathinone which is the principle component of Catha edulis ( Khat). The most spread synthetic cathinones are Butylone, Ethcathinone, Ethylone,3-Fluoromethcathinone, 4-Fluoromethcathinone, Buphedrone, Mephedrone, Methcathinone, Methedrone, Methylone, Naphyrone, Pentedrone and Pyrovalerone. [3] Nowadays there is a serious concerns about the impacts of synthetic cathinones on public health [3,4]. As several studies show that synthetic cathinones have been linked with intoxicants and fatal overdose.[3,4,5] The rapid spread of these substances and the rising use of illegal networks making the need for more information about the dangers that may cause of synthetic cathinones.[3] For the these reasons, the forensic toxicology community faces a difficult …show more content…
As the GC/MS technique is the most technique used in forensic toxicology laboratories. The second aim in this work will be to study the stability of selected synthetic cathinones and their metabolites in the biological samples under different conditions . The final aim will be to understand the effects of selected synthetic
A review of literature confirms to the fact that substance abuse is a global phenomenon. The most of countries strongly prohibit use of illicit drugs. For this reason, the people who are addicted for to illicit drugs are now addicted to new active substances which are called legal highs . These substances are more freely available and they can produce similar effects to illicit drugs [1,2].
Synthetic cathinones are one of the important psychoactive substances groups and they are synthetic derivatives of cathinone which is the principle component of Catha edulis ( Khat). The most spread synthetic cathinones are Butylone, Ethcathinone, Ethylone,3-Fluoromethcathinone, 4-Fluoromethcathinone, Buphedrone, Mephedrone, Methcathinone, Methedrone, Methylone, Naphyrone, Pentedrone and Pyrovalerone. [3] Nowadays there is a serious concerns about the impacts of synthetic cathinones on public health [3,4]. As several studies show that synthetic cathinones have been linked with intoxicants and fatal overdose.[3,4,5] The rapid spread of these substances and the rising use of illegal networks making the need for more information about the dangers that may cause of synthetic cathinones.[3] For the these reasons, the forensic toxicology community faces a difficult …show more content…
As the GC/MS technique is the most technique used in forensic toxicology laboratories. The second aim in this work will be to study the stability of selected synthetic cathinones and their metabolites in the biological samples under different conditions . The final aim will be to understand the effects of selected synthetic