Goodpasture’s Syndrome, also known as Goodpasture’s Disease, antiglomerular basement antibody disease, or anti-GBM disease is an autoimmune disease affecting the lungs and kidneys. In this rare disease antibodies are formed that attack the collagen in the lungs and kidneys leading to kidney failure and bleeding in the lungs. The laboratory plays an important role in the diagnostic process of Goodpasture’s disease. Patients will experience edema, joint pain, changes of urine color, and electrolyte imbalances in the blood. Goodpasture’s Disease is treatable with steroids, different blood products, immunosuppressants, and has a good prognosis if diagnosed early. Some patients have a genetic predisposition to developing the disease. Other risk factors include exposure to organic solvents, tobacco use, and cocaine use. Antibodies may also be created as a result of untreated influenza and streptococcal infections. While modern medicine has made this disease rare, because of diagnostic techniques and access to medicine, it is an autoimmune disease that may aid in the treatment and prevention of other autoimmune diseases.
Disclaimer: This paper is based on current and previously conducted research and is, therefore, not the product of original research.
Keywords: Goodpasture’s Syndrome, antiglomerular basement antibodies, kidney, lung, autoimmune
Introduction Goodpasture’s Syndrome is an autoimmune disease in which cytotoxic anti-glomerular basement membrane…