Rna Initiation And Termination Sequences Essay

1461 Words Nov 28th, 2015 6 Pages
FPV is in the family Parvoviridae, which contains 26 species of virus that infect a broad host range, covering species from invertebrates to humans. Parvoviruses are small single stranded DNA viruses enveloped by a T=1 non-enveloped capsid protein. Replication of these viruses can only occur when the host cell is in S-phase of its mitotic cycle (15). FPV has a very small linear genome that is only 5 kilobases in length (4). The virus’s genome has specific sequences, similar to a TATA boxes, that initiate transcription of major virus specific mRNA. A combination of TGTAAAT at nucleotide 893 and TAAAATA at nucleotide 878 begin the transcription. mRNA transcription is terminated at nucleotide 3816 with the sequence AATAAA, which is characteristic of polyadenylation sites observed in eukaryotic cells (4). These transcription initiation and termination sequences play a role in viral replication, which will be further discussed later in context of the whole viral infection process. Another important part of FPV’s genome are the nucleotides that code for the capsid protein. These structural sequences are found in the rightward open reading frame of the genome. The virus’s unique capsid structure allows it to effectively bind to and infect feline cells. The capsid of FPV is made up of a large protein (VP1 at 80,000 Daltons) and a smaller protein (VP2 at 60,000 Daltons)(4). While there is a specific genetic sequence that codes from the VP1 protein, VP2 is modified from a precursor…

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