Compare And Contrast Pregabalin And Placebo Treatment Groups

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treatment group. Whereas, response rates defined as >50% reduction from baseline for 300mg/d was 24% (P=0.0372), 27% in the 450 mg/d (P=0.0038), and 30% in the 600 mg/d pregabalin (P=0.001), compared to 15% in placebo treatment group. Compared with placebo patients reported improvements in total FIQ scores for 450 mg/d and 600 mg/d doses (table ).
Pregabalin trials by Mease et al, (2008) showed statistically significant improvements in mean pain in all 3 treatment groups from baseline compared with patients receiving placebo treatment (300mg/d -1.84, 450 mg/d -1.87, 600 mg/d -2.06, Placebo -1.04, P30% reduction from baseline for 300mg/d was 43%, 43% in the 450 mg/d, and 44% in the 600 mg/d pregabalin, compared to 35% in the placebo treatment group. Although the response rates were higher in all 3 treatment groups compared to the placebo treatment group, the differences were not statistically significantly for any pregabalin dosage (table ). FIQ pain scores for all three pregabalin treatment groups were numerically but not significantly greater than the placebo treatment group (table 1).
Two randomized controlled trials by Sañudo et al, (2010-2011) showed significant improvements in health status in patients assigned to the exercise group over the control group. Significant improvements were seen in FIQ pain score after the 24-week intervention
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The 6-month trial with aerobic exercise showed improved health-related quality of life, FIQ scores, BID depression scale and SF-36 scores. The improvement in FIQ scores showed 14-15% magnitude of improvement which is a clinically relevant improvement seen in patients with FMS. Improvement in average BDI scores indicated that aerobic exercise can potentially improve depressive symptoms in patients with

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