Phenylketonuria or PKU is a common inborn error in metabolism, which results in a buildup of phenylalanine due to a defect mainly involving the hepatic enzyme phenylalanine hydroxylase. Newborns undergo for PKU screenings, but it does not necessarily mean that it cannot occur later in life. Diagnosis of this disease can be detrimental if untreated and presents in major neurological impairment such as mental retardation. PKU is a disease that requires management by pharmacologic treatment or restrictive dietary includes reduced consumption of proteins such as meat, milk, cheese or nuts. Psychological therapy can also be used for treatment of behavioral and cognitive disorders. Using literature reviews, further analysis findings of this disease
