Essay on Muscular Dystrophy And The Disease

1388 Words Nov 19th, 2015 null Page
Every year, thousands of people, mostly young children, are affected by the neuromuscular disease Muscular Dystrophy. There are many different types of Muscular Dystrophy and they differ based on which muscles are affected and what the causative protein in the body is. Muscular Dystrophy was first introduced to us in 1830 by Sir Charles Bell, who wrote of an illness that caused a great amount of weakness in young boys. Years later, a French neurologist by the name of Guillaume Duchenne accounted for a small group of boys who had the most common and severe form of the disease, later being named Duchenne Muscular Dystrophy after Guillaume Duchenne. It wasn’t until the late 1980’s that researchers founded what leads to or causes Duchenne Muscular Dystrophy. Duchenne Muscular Dystrophy (DMD) occurs when there is a defect in the gene that makes a protein called dystrophin. Dystrophin helps the cells in the muscle keep and hold their shape and strength. When dystrophin is absent, the “muscles break down and a person gradually becomes weaker” (4). Once the muscle cell is destructed due to lack of dystrophin, it is “replaced by fatty and connective tissues, and contractures develop” (5). Since DMD is an X-linked recessive inheritance, meaning that it is genetically passed from parent chromosomes to the child, boys are often more affected by the disease, while “females occasionally can exhibit milder symptoms’’ (2). DMD mainly affects the muscles including the “shoulder…

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