The Notch Signaling Pathway Paper

1137 Words 5 Pages
The small genome and the short life cycle of Drosophila melanogaster makes the use of this organism proper to understand the role of signaling pathways, mainly the Notch signaling pathway, in the development of sensory organs in organisms. The molecular interactions of some genes with the Notch signaling pathway can help us understand cell differentiation in sensory organs. The gene Hairless shows high levels of interaction with the Notch signaling pathway of Drosophila melanogaster. Hairless was first discovered by Bridges and Morgan in 1923 as a haploinsufficient mutation in Drosophila melanogaster (Maier Stumm et el.1992). The Notch signaling pathway signals the peripheral nervous system to produce developmental responses in Drosophila …show more content…
A more comprehensive study shows Hairless affecting complex processes involved in the peripheral nervous system and the formation of sensory organs. The Notch signaling complex has been identified as a signaling pathway to differentiate cells. The Hairless gene can be used to conduct further research into more functions of the Notch signaling pathway. New research has suggested that some specific Notch signals can give rise to some types of cancer. This research proposes ways to find this specific signals. Finally, the research presents attempts to block this type of signaling (Purrow …show more content…
The hairless gene in humans is recessive. hairless lacks a shared evolution with Hairless in Drosophila melanogaster. Yet, Hairless presents evolutionary history with other genes in Drosophila melanogaster. Hairless has developed an antagonistic relationship with the Suppressor of Hairless. The Hairless gene depends on epistatic interactions. Most bristle mutations tend to occur in epistatic interactions with other genes. Hairless gene shows epistatic interactions with Notch genes and target genes in the Notch signaling pathway.
Future research should set experimentations that block different pathways within the Notch signaling pathway. The research should identify the effects in the interaction of the product of Hairless with other gene products, produced by the blockage. The Hairless gene demonstrate that the phenotype of an organism does not provide information about the function of a gene. The expressivity of a specific phenotype is the result of gene-to-gene interactions, gene-to-protein interactions, and many other molecular

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