Gene Delivery And Photothermal Therapy

812 Words 4 Pages
Medicine has come a long way from blood sucking leeches of the 1700’s to the modern vaccination today. With the introduction to the world of nanotechnology in the 21st century, medicine and treatments have taken major leaps forward. Scientists have managed to theorize a new method in which to battle cancer with the help of nanomedicine. Instead of the separating 2 treatments, there is a theory in research that argues for the benefits combining them into a single nano-carrier which would support one another for effective treatment. What are these two methods? Gene delivery and photothermal therapy.
This does partake in the field of biomedicine, the application of biological and natural science principles into clinical practice (pg 99).
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Photothermal therapy uses a specific light on the light spectrum to produce heat in the treatment. Using this heat, it would eradicate the target cell in order to try and stop the cell division by slowing down its radius of effect (pg100). However, since it is new, there is a barrier with this method. First, it is still in the preclinical stages of research and while it is believed to work in theory, the method has yet to reach animal or human testing. Due to that, it stuck in small scale testing, however, positive results in testing are allowing it to gain ground in more dedicated research. Thus it leads to the combining of photothermal and gene …show more content…
Photothermal therapy would support the nano-carriers with the RNA by creating a pathway through the cell to the nucleus. In which the nanomedicine will introduce foreign RNA to modify the genetics while the reactivity of the heat from the P.T therapy would enhance the strength of the nucleotide. There are two methods for this drug delivery. One takes place above 50 degrees Celsius and the other lingers around 45 degrees Celsius. Although the process and materials are the same, the results differ greatly.
The first method of using heat higher than 50 degrees Celsius allows for a strong photothermal effect on the outer membrane of the cell. It would essentially be a battering ram, destroying the outer wall and allowing the therapeutic genes to slip on through. While the RNA gets to work, the photothermal would create an effect called ablation. Ablation would effectively neutralize the protein that is in the cell, thus rendering them harmless to the siRNA that is at

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