Immunotherapy: The War On Cancer

Improved Essays
The “war on cancer” is now in its fourth decade since the president Richard Nixon declared war against cancer, leading to the National Cancer Act in 1971. Since 2004, when National Cancer Institute launched the Alliance for Nanotechnology in Cancer, a lot of efforts and massive fundings have been devoted to the development of novel nanotechnologies in order to reduce cancer mortality.
Although localized primary solid tumors can be successfully removed surgically, the treatment of spreading tumors and tumor metastases requires extensive chemotherapy which aims to kill tumor cells or to inhibit their proliferation while preserving the normal cells in the body. However, two main obstacles limit the success of chemotherapy: the lack of tumor

Related Documents

  • Decent Essays

    B6190 Description: IC50: 1.7-4.0 μM for tested cancer cell lines NSC348884 is a nucleophosmin inhibitor. Nucleophosmin is identified as a multifunctional nucleolar phosphoprotein, which is dysregulated in human malignancies resulting in anti-apoptosis and differentiation inhibition. In vitro: NSC348884, which was identified as a putative nucleophosmin small molecular inhibitor, was found to be able to disrupt a hydrophobic pocket that was required for oligomerization, and NSC348884 could also inhibit the cell proliferation in distinct cancer cell lines and disrupt nucleophosmin oligomer formation. Moreover, the treatment of several cancer cell types with NSC348884 could dose-dependently upregulate p53 and also induce apoptosis that correlated with H2AX phosphorylation, poly(ADP-ribose) polymerase cleavage as well as Annexin V. Furthermore, NSC348884 could also synergize doxorubicin cytotoxicity on the viability of cancer cells [1].…

    • 198 Words
    • 1 Pages
    Decent Essays
  • Great Essays

    The Center for Nanotechnology in Cancer (CNTC) at the Dana-Farber Cancer Institute in Boston, MA is forced to assess its organization situation in 2010. According to the case study, written by Heidi K. Gardner, Edo Bedzra, and Shereef M. Elnahal titled Ganging Up on Cancer: Integrative Research Centers at Dana-Farber Cancer Institute (A): The mission of the CNTC is to transform cancer therapy by enabling the early detection of cancer using nanoparticles and molecular imaging, as well as by developing new treatments with tumor- targeting technology. Specifically, the major activities of the center will focus on identifying unique biomarkers that could be targeted with nanoparticles themselves or antibody-labeled nanoparticles, and captured with…

    • 1110 Words
    • 5 Pages
    Great Essays
  • Great Essays

    1) 2) Explain the mechanism of how the nanoparticle system delivers the drug to the cancer cell. Blood is taken from a patient. The platelets are collected from that blood. The isolated platelets are treated to extract the platelet membranes, which are then placed in a solution with a nanoscale gel containing the anticancer drug doxorubicin (Dox), which attacks the nucleus of a cancer cell. The solution is compressed, forcing the gel through the membranes and creating nanoscale spheres made up of platelet membranes with Doxgel cores.…

    • 1031 Words
    • 5 Pages
    Great Essays
  • Decent Essays

    Cancer therapies are currently limited to surgery, radiation, and chemotherapy. All three methods risk damage to normal tissues or incomplete eradication of the cancer. Nanotechnology offers the means to aim therapies directly and selectively at cancerous cells. Conventional chemotherapy employs drugs that are known to kill cancer cells effectively. But these cytotoxic drugs kill healthy cells in addition to tumor cells, leading to adverse side effects.…

    • 249 Words
    • 1 Pages
    Decent Essays
  • Improved Essays

    Systemic Chemotherapy

    • 527 Words
    • 3 Pages

    Drug targeting of the chemotherapeutic molecules - carboplatin and paclitaxel during Cycle 2 through 6 and an additional Cycle 7, in a case of advanced, recurrent, metastatic, nasopharyngeal carcinoma (NPC) as part of a proof of concept pilot study, is reported. Systemic chemotherapy was enabled by the concurrent use of non-ionizing, safe radio-frequencies (RF) using specialized antennae in the presence of instantaneous magnetic resonance (MR). FORN is used to create temporary, drug molecular weight-specific nano-pores in the cell membrane of target…

    • 527 Words
    • 3 Pages
    Improved Essays
  • Superior Essays

    Innovative technology and cancer research surround today’s world; experts are learning new things daily. At first glance, chemotherapy or radiation therapy seem to be the only options of treatment; however, this…

    • 1504 Words
    • 7 Pages
    Superior Essays
  • Improved Essays

    Malignant tumors rapidly spread throughout the body, attacking tissues and the surrounding regions. The only cure for this tumor…

    • 815 Words
    • 4 Pages
    Improved Essays
  • Brilliant Essays

    Nanotechnology: Benefits and Dangers Assessment Task 1 for SLE155: Essential Skills in Bioscience Part A: Bibliography George, S., Ho, S., Wong, E., Tan, T., Verma, N., Aitken, R., Riediker, M., Cummings, C., Yu, L., Wang, Z., Zink, D., Ng, Z., Loo, S. and Ng, K., 2015. The multi-facets of sustainable nanotechnology – Lessons from a nanosafety symposium. Nanotoxicology, 9(3), pp.404-406.…

    • 1059 Words
    • 5 Pages
    Brilliant Essays
  • Superior Essays

    Cancer has many forms of treatment, but the two that are known to most are chemotherapy and radiation therapy. Chemotherapy is the use of drugs like cytotoxic and others, where as radiation therapy is the use of x-rays or other similar forms of radiation to cure cancer. Arguments can and more than likely always arise that one form of the two treatments is more beneficial and effective than the other. Considering this, the type of treatment that may be used can differ for each type of cancer, just depending on which one is more useful for the particular illness. The two treatment may differ in a few ways but the biggest one can be the side effects of each one.…

    • 1260 Words
    • 5 Pages
    Superior Essays
  • Improved Essays

    Breast cancer is one of the leading cancers that affect a myriad of people in today’s society. “About 1 in 8 U.S. women (about 12%) will develop breast cancer over the course of her lifetime.” (Breast Cancer, 2016). Some people diagnosed with this type of cancer could have the opportunity to detect it early on due to screenings or self-evaluations. However despite early detection, it does not guarantee that the cancer can be treated in its entirety.…

    • 725 Words
    • 3 Pages
    Improved Essays
  • Great Essays

    Nanotechnology has also been introduced to facilitate current treatment and advance new therapeutic strategies (Mamo et al., 271). To compliment this form of treatment, doctors are always coming up with better diets and lifestyles to help prolong the lives of those living with…

    • 1455 Words
    • 6 Pages
    Great Essays
  • Improved Essays

    The Benefits Of Malignancy

    • 1017 Words
    • 4 Pages

    Where is the bottleneck in the movement of creating tumor? Results like these propose that the issue is not the changes prompting a threatening line of cells that is the sign occasion on the grounds that this happened a few times. Possibly a stand-down of the body 's safe barriers is the most vital occasion prompting clinical malignancy. On the off chance that the neoplastic transformation has officially occurred a few times freely, then it is a waste of time to stamp out each and every growth cell. On the off chance that growth has as of now advanced from sound cells different times inside of the same patient, then the creature is certain to repeat unless we treat the reason, which is the shortcoming of the body 's natural…

    • 1017 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    Nanotechnology and Cancer: A Look into Better Options Since the beginning of time, human beings have been felled by disease and one of the most common killers of humans and animals as well. Until recently cancer has gone uninterrupted in its mass killing spree. Methods of treatment began to arise such as radiotherapy and chemotherapy. Now technology has advanced enough to allow nanotechnology to arise.…

    • 1656 Words
    • 7 Pages
    Great Essays
  • Improved Essays

    The use of these nanoparticles will overshadow the harmful effects because they detect proteins, create fluorescent biological labels for important biological markers and molecules in research and diagnosis of diseases, isolate and purify biological molecules and cells in research. Most importantly, nanoparticles are used for gene delivery systems in gene therapy, which is the key factor for personalized medicine. These nanoparticles will cause a life time change in the field of medicine for doctors, biomedical engineers, clinicians and many others who work within this industry. Now, people will be able to be treated with a medication that targets their genetic material. By doing this, the health care system will evolve into a place where cancer can be curable.…

    • 1033 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    Anton Cancer: A Case Study

    • 3418 Words
    • 14 Pages

    Based on the data reported by the world health organization’s cancer control program, approximately 11 million people are diagnosed with cancer every year, so if this rate continues then, by 2020 there will be around 16 million new cases of cancer every year (sunil kumar deshmukh and shilpa verekar 2014). Cancer is a multifactorial disease caused due to hormonal and metabolic imbalances, changing lifestyle, nutrition, global warming genetic aberration/changes and infections (Maurya 2011). Most of previous chemical anticancer drugs exhibits nonspecific toxicity to normal growing cells, possess lot of side effects, and are ineffective against many types of cancer (Strobel 1997). Thus for effective treatment of cancer one must develop new improved diagnostic technique so that earlier detection and more accurate treatment can be done at an initial stage of cancer. Recently due to technological advancement we could get a better insight about the genetics and molecular biological aspect of cancer, which in turn have led to increased identification of potential molecular targets for anticancer drug discovery and development (Hanahan and Weinberg 2011).…

    • 3418 Words
    • 14 Pages
    Great Essays