Dementia Case Studies

Few decades ago, developments in health care have given to individuals to be more healthy and living longer. As a result, the number of people with non communicable diseases such as dementia is reduced. Despite dementia principally influence older people; it is not usual part of ageing. Dementia is a syndrome caused by a numerous of brain illnesses leading to loss memory, abnormal behavior, disability and cause extreme effect in individuals’ lives. Alzheimer disease (AD) is the major form of dementia and the responsible for two-third of dementia cases. Approximately, 35.6 million of world population were suffering from dementia in 2010 and predicted to be 65.7 million after two decades. The global prevalence of dementia has increased dramatically …show more content…
, 2000). From the point of genetics, the incidence of this health issue will be increased significantly if there is a family member suffers from AD. It has been admitted that the reason behind the progression of AD includes inflammatory mechanisms during aging stage. According to (Cunningham et al., 2009). the neurodegeneration caused by proinflammatory cytokines in mice. So, the inflammatory process is proved by the fact that neurons are greatly sensitive to destructive free radicals which damage brain cells. The lesions in the brains of AD patients diagnosed by measuring damaged DNA, protein oxidation, advanced glycosylation metabolites, lipid peroxidation and apoprotein E ( Carro et …show more content…
Dietary antioxidants have potential effect in AD treatment. Polyphenols are potential components in nature act as free radicals scavengers, such as: anthocyanins, flavins, catechins, curcumin, and resveratrol. Some studies have demonstrated the vital role of phytochemicals in preclinical models of AD. Particularly, resveratrol has neuroprotective property against a neurotoxic peptide named by Aβ plays a vital role in the neuropathology of AD (Butterfield, 2002; Jang and Surh,