Biological Functions And Functions Of Crp Essays

1133 Words May 27th, 2016 null Page
Biological functions: The main biological functions for CRP to determine via its ability to identify pathogens and injured cells of the host and mediate their elimination via activating the complement system and phagocytic cells (Brundish and Baddiley,1968 ; Weiser et al., 1997). CRP binds to microorganisms and mediates their killing to more recent observations of protection against bacterial pathogens in CRP transgenic mice. The most significant evidence has supported the notion that CRP plays an important role in host defense. CRP mediates protection due it supports three main effector functions, firstly activation of complement, secondly the induction of phagocytosis and finally plays a key role in opsonization (Szalai, 2002a).
More relevant to the function of CRP is human secretory phospholipase A2 with CRP may serve to promote phagocytosis of injured cells and tissue debris, an enzyme secreted by liver as an acute phase protein (Hack, 1997). Activation of complement by C1q and binding to FcγRs are the two functions that supposed to be mediated via the effector face which is the opposite side of the CRP molecule and can bind to C1q and FcγRs. The ability of CRP to increase the clearance of host apoptotic, necrotic cells and nuclear antigens suggests another function, prevention of autoimmunity (Du Clos and Mold, 2011).
The binding sites in CRP play a significant role recognizing and binding to a different variety of biological substrates, containing PC and phospholipid…

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