James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 80(6), 1611-1617.
Article Summary
Introduction
Autism covers complex neurodevelopmental disorder usually evident in the early stages of childhood and is believed to be influenced by genetic and environmental factors. Abnormal metabolism regarding methionine and homocysteine are linked with another neurologic disease although the evaluation of this fact in persons with autism is underway.
Hypothesis
The purpose of the study aims at evaluating plasma concentrations of metabolites present …show more content…
Design and Procedure
The study put forth all the significant levels and the right process to realize the hypothesis. Further, the nutritional intervention trial was included in the subdivision of the autistic children, which facilitated the goal realization.
Results
Every content of the plasma concentration showed positive results highlighting proper processes such as lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and grand glutathione.
Discussion (recommendation and conclusion)
The research purposefully concentrated on the appraising plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children with autism. Therefore, increased vulnerability to oxidative stress and decreased capacity for methylation should be encouraged as it contributes to the development and clinical manifestation of autism (James et al., …show more content…
The data revolves around autism hospitalization, which may lead to under-ascertainment of autism cases since many diagnosis instances are done in an outpatient setting. Besides, the diagnoses do not reflect the actual onset of symptoms encompassing regression.
References
DeWilde, S., Carey, I. M., Richards, N., Hilton, S. R., & Cook, D. G. (2001). Do children who become autistic consult more often after MMR vaccination?. Br J Gen Pract, 51(464), 226-227
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 80(6), 1611-1617.
Mäkelä, A., Nuorti, J. P., & Peltola, H. (2002). Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics, 110(5),
Article Summary
Introduction
Autism covers complex neurodevelopmental disorder usually evident in the early stages of childhood and is believed to be influenced by genetic and environmental factors. Abnormal metabolism regarding methionine and homocysteine are linked with another neurologic disease although the evaluation of this fact in persons with autism is underway.
Hypothesis
The purpose of the study aims at evaluating plasma concentrations of metabolites present …show more content…
Design and Procedure
The study put forth all the significant levels and the right process to realize the hypothesis. Further, the nutritional intervention trial was included in the subdivision of the autistic children, which facilitated the goal realization.
Results
Every content of the plasma concentration showed positive results highlighting proper processes such as lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and grand glutathione.
Discussion (recommendation and conclusion)
The research purposefully concentrated on the appraising plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children with autism. Therefore, increased vulnerability to oxidative stress and decreased capacity for methylation should be encouraged as it contributes to the development and clinical manifestation of autism (James et al., …show more content…
The data revolves around autism hospitalization, which may lead to under-ascertainment of autism cases since many diagnosis instances are done in an outpatient setting. Besides, the diagnoses do not reflect the actual onset of symptoms encompassing regression.
References
DeWilde, S., Carey, I. M., Richards, N., Hilton, S. R., & Cook, D. G. (2001). Do children who become autistic consult more often after MMR vaccination?. Br J Gen Pract, 51(464), 226-227
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 80(6), 1611-1617.
Mäkelä, A., Nuorti, J. P., & Peltola, H. (2002). Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics, 110(5),