Alzheimer 's Effects On The Brain Essays

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Alzheimer’s presents changes in the brain referred to as neuritic plaques and neurofibrillary tangles. The neuritic plaques are formed when amyloid precursor proteins are not processed, resulting in toxic amyloid beta proteins, forming to make plaques. Neurofibrillary tangles are formed from the tau protein, a microtubule-binding protein, detaching from neurons to form tangles. Both plaques and tangles contribute to the death of neurons, resulting in the hallmark features of Alzheimer’s disease (McCance & Huether, 2014). These plaques and tangles begin in the entorhinal cortex, and exhibit some of the initial signs of Alzheimer’s disease. The entorhinal cortex is part of the temporal lobe and is involved in memory and the connection of the hippocampus and neocortex. The neuron death continues by the formation of plaques and tangles in the hippocampus and isocortex. The hippocampus is also part of the temporal lobe and is the area of the brain that controls long-term memory and spatial navigation. The isocortex and neocortex is the largest area of the cerebral cortex. The cerebral cortex is the outer gray matter of the cerebrum, split into the right and left hemisphere, further split into four lobes: the frontal, parietal, temporal, and occipital lobe. Aside from the atrophy and general spread of tangles and plaques in the cerebral cortex, the amygdala located in the temporal lobe is also affected, which is an area of the brain that controls emotional reactions and…

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