A Study On Severe Combined Immune Deficiency Essay

1413 Words Oct 19th, 2016 6 Pages
Severe Combined Immune Deficiency as described by the immune deficiency foundation, is a “cellular immunodeficiency and a potentially fatal primary immunodeficiency in which there is combined absence of T-lymphocyte and B-lymphocyte function” (Immune Deficiency Foundation IDF, 2016). The lymphatic system comprises of organs and tissue that produce immune cells and one of their main functions is to confer immunity to every part of the body. The function of the T-lymphocyte and B-lymphocyte in the lymphatic immune system cannot be overstressed as they make up the major responses that the immune system gives when it encounters a foreign antigen. Hematopoiesis is a process that involves the generation of most cells involved in immune reactions including the lymphocytes. The lymphocytes are produced by leukopoiesis in the bone marrow because they are types of white blood cells. The pluripotent hematopoietic stem cells develop first into distinct types of colony forming units (CFUs) and then they develop into common lymphoid progenitors first before forming the T or B lymphoid progenitors.
These newly born lymphocytes then move on to the next stage of maturation and the B-lymphocytes matures in the bone marrow while the T-lymphocytes mature in the thymus. They both need to undergo a positive or negative selection to become immunocompetent which entails their ability to bind to foreign materials, MHCs and all other kinds of antigens presented to them by the reticular cells to test…

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