Glucocorticoid

Glucocorticoids are steroid hormones which are produced predominantly in response to stress in the adrenal gland (Davis & Sandman 2010; Korgun et al. 2012). The physiological effects of glucocorticoids occur when the hormone are bind to, and mediated by the glucocorticoid receptor (Erhuma 2012). It plays a wide range of vital physiological roles that are necessary for healthy implantation and pregnancy processes (Korgun et al. 2012). As glucocorticoids are critical in the regulation of the metabolic, cardiovascular, and the immune system (Drake, Tang & Nyirenda 2007; Manojlović-Stojanoski, Nestorović & Milošević 2012), excess exposure to it can inhibits the growth and development of tissues and organ systems and increase the risk of developing…

Glucocorticoid are primarily used therapeutically as anti-inflammatory and immunosuppressive agent. They are secreted from the adrenal cortex of the adrenal gland in a circadian manner or in response to stress perceived by the brain. They are able to modulate physiological homeostasis and coordinate those adaptive responses to stressors. An imbalance in glucocorticoid levels, specifically chronic glucocorticoid has been associated with a number of neuropsychiatric disorders, specifically…

The prolonged use of therapeutic glucocorticoids is associated with a range of adverse effects (figure 1). The detrimental effects on bone have received the greatest focus and there are now a range of therapeutic strategies available to reduce the negative effects of glucocorticoids on bone [1]. Endogenous or exogenous glucocorticoid excess is also associated with other serious clinical features such as the development of insulin resistance, impaired glucose tolerance and frank diabetes [2].…

Dermatology Clinic: Questions and Answers Case 1 1. What is your diagnosis? This patient exhibits signs and symptoms of iatrogenic Cushing syndrome with steroid acne due to corticosteroid withdrawal. 2. What factors may have contributed to the disease? The chronic treatment with high doses of prednisone contributed to the patient’s Cushing syndrome. However, steroid withdrawal may have caused her recent skin flare around her trunk and extremities. 3. What is the treatment of choice for this…

Antiseizure medicines. Androgens. Estrogen. Glucocorticoids. If you will have a saliva test, follow instructions from your health care provider about when to stop eating, drinking, and using toothpaste before the test. If you will have a urine test, no specific preparation is needed. Tell a health care provider about: Any allergies you have. All medicines you are taking, including vitamins, herbs, eye drops, creams, and over-the-counter medicines. Any blood disorders you have. Any surgeries you…

Cushing syndrome refers to the complex clinical manifestations resulting from chronic exposure to excess cortisol. Cushing disease is overproduction of pituitary ACTH by a pituitary adenoma (McCance, Huether, Brashers, & Rote, 2014, p. 754-755). Cushing’s disease is defined by Adrenocorticotropin hormone (ACTH) hypersecretion, induced by a corticotrophic adenoma, leading to cortisol and androgen hypersecretion. Cushing’s disease may lead to death if untreated; it is responsible for increased…

Cushing syndrome is a silent disease that hides behind extreme weight gain and a variety of seemingly random symptoms. Its name can change depending on the origin of the illness. Cushing syndrome refers to all patients with the classic symptoms and signs of the condition regardless of the cause, while Cushing disease is reserved for patients in which the signs and symptoms are caused by an adrenocorticotropic hormone (ACTH) secreting tumor. Of all the patients with spontaneously occurring…

Cushing’s Disease Description Cushing’s Disease is an adrenal gland disease in which there is an excess of the steroid hormone, cortisol, within the body. With Cushing’s Disease the body releases too, much of the adrenocorticotropic hormone (ACTH). This disease is rare as it effects 10 to 15 people per million each year. Women and men both can be diagnosed with this disease, but women tend to be affected more than men. The disease can be fatal is not treated correctly and promptly. Etiology…

7th November, 2014 Efficacy and safety comparisons between collagen derivatives and glucosamine sulfate supplements in treating adults with knee osteoarthritis. Linh Nguyen (11916828). Evidence based practice. University of Technology, Sydney I. CLINICAL SCENARIO During my clinical placement, I have come across a scenario where a 40 year old woman came into the pharmacy, saying that she had recently diagnosed with knee osteoarthritis (KOA) and was looking for a good dietary supplement as…

Although there is no cure for muscular sclerosis there just a few treatments that can help control the symptoms. A variety of medications are prescribed in several forms such as orally, intravenous or by injection. Treatment for attacks includes corticosteroids to reduce nerve inflammation. Medications for depression, sexual dysfunction and bladder and bowel control may also be prescribed. Medications administered by injection subcutaneously or intramuscularly are Beta interferons for…