Glucocorticoid are primarily used therapeutically as anti-inflammatory and immunosuppressive agent. They are secreted from the adrenal cortex of the adrenal gland in a circadian manner or in response to stress perceived by the brain. They are able to modulate physiological homeostasis and coordinate those adaptive responses to stressors. An imbalance in glucocorticoid levels, specifically chronic glucocorticoid has been associated with a number of neuropsychiatric disorders, specifically depression, PTSD, and even bipolar disorder. Glucocorticoid can activate the glucocorticoid receptor (GR). GR is an intracellular steroid hormone receptor. In the absence of steroid, GR is typically localized to the cytoplasm of the cell where it is bound to
