Related Essays

  • Conjugated Drugs Research Paper

    • Polymers should be able to carry the required load of the drug. • Polymers should be able to protect the drugs against premature metabolism in delivery. ...

  • Solubility And Bioavailability Of Ginkgo Biloba Extract

    The uniqueness of this kind of formulations is the absence of interactions between drug and carrier which makes the system thermodynamically stable in which...

  • Nt1310 Unit 1 Case Study Answers

    When the tablet is swallowed, the overcoat of the drug will dissolve quickly and the initial release can increase the drug concentration rapidly and it is si...

  • What´s Multiparticulate Drug Delivery System?

    There are currently two systems of matrix delivery system including hydrophobic matrix tablets (Abdel-Rahman, Mahrous and El-Badry, 2009) which release drug ...

  • Oral Liquid Formulations

    Section Two - Oral Liquid Formulations (1) Characteristics of Suspensions: The oral liquid dosage form chosen to formulate was that of a suspension. Given ...

  • USP Apparatus A Case Study

    It is this agitation that will cause disintegration and erosion of the matrix of the dosage form, followed by dissolution of the drug particles (Bianca). The...

  • (IR) Spectra Of The Fluconazole Release Of PVA Nannofibers?

    The release rate of the drug in the system related to solubility, degradation and swelling, including the properties affecting the mechanism and rate of drug...

  • Positive Hydrogels Research Paper

    Research on drug delivery systems has mainly focused on hydrogels because hydrogels not only reduce common problems associated with drug dosage but also new ...

  • Metronidazole Light Essay

    During vulcanization insoluble film of rubber entrap the suspended drug particles, this his leads to decrease in penetration of dissolution fluid and leachin...

  • Explain The Limitation Of Risperidone

    Each particle in the white microsphere powder consist of small beads of microspheres loaded with a matrix of the polymer poly (d ,l -lactide-co-glycolide), P...

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/21

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

21 Cards in this Set

  • Front
  • Back
Molecules to deliver
***Growth factors
* steroids
* anti-inflammatories/immuno-supressants
TYPES OF RELEASE

bolus
one single delivery (ex: injection)
TYPES OF RELEASE

sustained
delivery is prolonged
TYPES OF RELEASE

controlled
predictability and reproducibility of dose delivery
DELIVERY MECHANISMS

systemic
addition of a bolus; uncontrolled; requires a lot of the growth factor
DELIVERY MECHANISMS

soluble delivery
growth factor is adsorbed or entrapped in the scaffold
DELIVERY MECHANISMS

tethered
- can be covalent or non-covalent bonds
- release can be mediated by cellular activity
- we have more control over time of delivery
TYPES OF SOLUBLE DELIVERY

dissolution
- growth factor is directly soluble in the polymer
- completely homogeneous
TYPES OF SOLUBLE DELIVERY

adsorption
- only if the scaffold supports protein adsorption
- commonly used with PLGA
TYPES OF SOLUBLE DELIVERY

emulsions
- growth factors are phase-separated from the rest of the polymer
- allows tailoring of release from the pocket
TYPES OF SOLUBLE DELIVERY

suspension
- growth factors are not soluble in the polymer
- not released until the polymer degrades
how to make an interspersed loading homogeneous
** dissolution **
1) mix growth factor in polymer solution
2) cross-link the material
how to make an interspersed loading heterogeneous
- adsorb onto surface
OR
- emulsion
INTERSPERSED DELIVERY MECHANISMS

solely diffusion
- controlled by diffusion coefficient
- use if growth factors can fit through scaffold pores
INTERSPERSED DELIVERY MECHANISMS

diffusion and bulk degradation
- growth factor diffuses as polymer degrades
INTERSPERSED DELIVERY MECHANISMS

surface erosion
- growth factor released with surface hydrolysis
altering material release profiles
- porosity
- degradation
altering growth factor release profiles
- all growth factor properties
growth factors can be affected by:
- chemicals
- pH changes
- adsorption
how to alter delivery of covalently tethered growth factors
degrade the cross-linker, either hydrolytically or enzymatically
how to alter delivery of heparin-bound growth factors
alter the ratio of heparin to growth factor; more heparin = slower release