The infrared (IR) spectra of PVA nanofibers are shown in figure 3-a. According to this figure, polyvinyl alcohol FTIR spectrum has peaks at 1655 cm-1 relating to the bending band of (HOH) peaks in 2910 cm-1 and 2940 cm-1 related to the stretching bands of (CH2) and Peaks at 1710 cm-1 and 1573 cm-1 are related to the carbonyl group. Also, the peak in 1142 cm-1 indicating the presence of oxygen atoms, the band at 1097 cm-1 is assigned to (C-O) stretching vibration of the ether group and peaks at 851 cm-1 and 607 cm-1 represent stretching vibrations (C-C), which is correspond with reports of other researchers [ ]. It also can be seen in figure 3-b, IR spectra of fluconazole that corresponded with reports of other researchers [ ]. Figure 3-c shows
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In this system, the phenomenon of burst release, the drug release trend, and the full release time was evaluated. According to the figure 4, the general trend release diagram of the fluconazole loaded samples in the system has been shown. According to this figure, the drug release is sudden and about 75% of the drug was released in the first 90 minutes from the start time of the release …show more content…
This fast release can be attributed the drug on the outer surface of the nanofibers as well as high specific surface area of nanofibers. After it’s, the release rate was decreased and after about 8 hours, the drug was released in delivery environment. In this system, the drug release is operated by diffusion and degradation mechanisms. The general trend release in samples containing different amounts of the drug was almost similar. Just it can be seen that by increasing the amount of drug samples, the initial release rate increases. The release rate of the drug in the system related to solubility, degradation and swelling, including the properties affecting the mechanism and rate of drug delivery. The probability of drug existence on the surface of fibrous mat increases by increasing the amount of drug in polymer solution. This matter leads to the increasing sudden rate of drug release at the start of releasing
In this system, the phenomenon of burst release, the drug release trend, and the full release time was evaluated. According to the figure 4, the general trend release diagram of the fluconazole loaded samples in the system has been shown. According to this figure, the drug release is sudden and about 75% of the drug was released in the first 90 minutes from the start time of the release …show more content…
This fast release can be attributed the drug on the outer surface of the nanofibers as well as high specific surface area of nanofibers. After it’s, the release rate was decreased and after about 8 hours, the drug was released in delivery environment. In this system, the drug release is operated by diffusion and degradation mechanisms. The general trend release in samples containing different amounts of the drug was almost similar. Just it can be seen that by increasing the amount of drug samples, the initial release rate increases. The release rate of the drug in the system related to solubility, degradation and swelling, including the properties affecting the mechanism and rate of drug delivery. The probability of drug existence on the surface of fibrous mat increases by increasing the amount of drug in polymer solution. This matter leads to the increasing sudden rate of drug release at the start of releasing