Albuterol (also known as Salbutamol) is a medication indicated for the treatment of both asthma and chronic obstructive pulmonary disease (COPD). This agent works by activating 훽2-adrenergic receptors in the lungs, causing bronchodilation and improving airway patency. In the acute care setting, albuterol is often given via nebulization.1,2 The tablet formulation of albuterol exists as well. However, with albuterol having a low systemic bioavailability, ordering albuterol in its tablet form is not appropriate. Therefore, pulmonary drug delivery is typically the preferred route of administration for the treatment of asthma and COPD. Albuterol exhibits a single dose therapy effect.3,4 Once albuterol enters the body, it will change from an out-of-balance
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One key factor in drug delivery to the lung is particle size.5 In order for a drug to enter the bronchial tree, the size of the drug particle must range between 1-5 µM. Particles that are less than 1 µM typically remain suspended in the air, while particles that are greater than 5 µM are not able to travel deep into the lungs thus the drug therapy is not effective. Also, studies show that only about 10-30% of inhaled or nebulized drug enters the bronchial tree. The other remaining percent enters the gastrointestinal tract. These factors should be considered in developing new dosing …show more content…
They are one of the leaders in pulmonary drug delivery systems. Their devices, the Aerogen Solo and the Aerogen Ultra, are currently being used in hospitals around the world. These devices can be used with nebulizer devices commonly found at various healthcare settings. Based on clinical studies, patients who utilized nebulization treatment with Aerogen products received on average 9-times more drug delivery into the lungs than conventional device types like jet and ultrasonic nebulizers.7 What makes these products unique is the vibrating mesh technology. The vibrating mesh can take a single drop of a liquid (or aerosol) drug and convert it into millions of smaller particles. As stated previous, particle size is an important factor in pulmonary drug delivery. Hence, more drug can be delivered using the standard dose of a
One key factor in drug delivery to the lung is particle size.5 In order for a drug to enter the bronchial tree, the size of the drug particle must range between 1-5 µM. Particles that are less than 1 µM typically remain suspended in the air, while particles that are greater than 5 µM are not able to travel deep into the lungs thus the drug therapy is not effective. Also, studies show that only about 10-30% of inhaled or nebulized drug enters the bronchial tree. The other remaining percent enters the gastrointestinal tract. These factors should be considered in developing new dosing …show more content…
They are one of the leaders in pulmonary drug delivery systems. Their devices, the Aerogen Solo and the Aerogen Ultra, are currently being used in hospitals around the world. These devices can be used with nebulizer devices commonly found at various healthcare settings. Based on clinical studies, patients who utilized nebulization treatment with Aerogen products received on average 9-times more drug delivery into the lungs than conventional device types like jet and ultrasonic nebulizers.7 What makes these products unique is the vibrating mesh technology. The vibrating mesh can take a single drop of a liquid (or aerosol) drug and convert it into millions of smaller particles. As stated previous, particle size is an important factor in pulmonary drug delivery. Hence, more drug can be delivered using the standard dose of a