What´s Multiparticulate Drug Delivery System?

Reservoir Systems consist of a hollow inner core and a polymer membrane, there to control the rate of drug diffusion. Drug diffusion across the membrane is rate limited and controls general drug release rate (Bajpai et al. 2008). For reservoir systems drug release normally remains steady resulting in a zero order profile (Raval, Parikh and Engineer, 2010). Another technology is called the Multiparticulate drug delivery system which consists of microencapsulated granules/beads containing drug packed inside a capsule or compressed into a tablet (Patwekar, and Baramade, 2012). This system is highly fitting to achieve controlled release oral formulations and is advantageous compared to conventional therapy due to the fact that Multiparticulate systems would not have to be administered at frequent times of the day. There are three ways drug can be released from multiparticulate systems, the first being diffusion out of the carrier upon contact with aqueous fluids. The …show more content…
There are currently two systems of matrix delivery system including hydrophobic matrix tablets (Abdel-Rahman, Mahrous and El-Badry, 2009) which release drug after the tablet has been dissolved by a solvent and hydrophilic matrix tablets (Asija and Bansal, 2013) which are dependent upon the swelling of the outer layer of the tablet to allow drug to diffuse out (Kim, 1995). Both of these systems consist of drug inside a matrix tablet which will be released over a prolonged amount of time. Hydrophobic polymers are widely accepted for use as they offer many advantages such as exhibiting superior stability at different pH’s (Tiwari et al., 2003). But in this project hydrophilic tablets are going to be used to test the effect of different variables on drug