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10 Cards in this Set
- Front
- Back
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Halflife of digoxin
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Long: 40 hours
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Excretion of digoxin
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Urinary
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MoA of digoxin
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Directly inhibits Na/K ATPase, leading to indirect inhibition of Na/Ca exchanger. This causes intracellular Ca levels to rise (intracelluar Na also rises). This increases contractility
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MoA of digoxin (simple)
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Increases contractility and stimulates vagus nerve
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Clinical uses of digoxin
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CHF (since it increases contractility); atrial fibrillation (decreases conduction at the AV node, and depresses SA node)
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ECG abnormalities seen with digoxin
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Increases PR interval, decreased QT interval, "scooping" of ST segment, T wave inversion
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Side effects of digoxin
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ECG abnormalities, increased PANS activity (n/v, diarrhea, blurry vision), arrhythmia
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What increases the toxicity of digoxin?
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Renal failure, hypokalemia, quinidine.
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Important drug-drug interaction of digoxin
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Quinidine decreases digoxin clearance
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Antidote for digoxin poisoning
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Slowly normalize K, lidocaine, cardiac pacer, anti-dig Fab, magnesium
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