Step 1 - Pharm - Gi Drugs

Front 1

MOA of cimetidine

Back 1

Reversible H2 blocker. Decreases H+ secretion by parietal cells

Front 2

MOA of ranitidine

Back 2

Reversible H2 blocker. Decreases H+ secretion by parietal cells

Front 3

MOA of famotidine

Back 3

Reversible H2 blocker. Decreases H+ secretion by parietal cells

Front 4

MOA of nizatidine

Back 4

Reversible H2 blocker. Decreases H+ secretion by parietal cells

Front 5

Clinical uses of H2 blockers

Back 5

Peptic ulcer, gastritis, mild esophageal reflux

Front 6

Side effects of cimetidine

Back 6

CYP450 inhibitor, antiandrogenic (prolactin release, gynecomastia, impotence, decreased libido in males), CNS effects (can cross BBB and cause confusion, dizziness, headaches) and can cross placenta

Front 7

These two H2 blockers decrease renal excretion of creatinine

Back 7

Cimetidine, ranitidine

Front 8

MOA of omeprazole

Back 8

Irreversible inhibitor of H/K-ATPase in parietal cells (proton pump inhibitor)

Front 9

MOA of lansoprazole

Back 9

Irreversible inhibitor of H/K-ATPase in parietal cells (proton pump inhibitor)

Front 10

Treatment for Zollinger-Ellison syndrome

Back 10

Proton pump inhibitors (omeprazole, lansoprazole)

Front 11

Clinical uses of PPI's

Back 11

Peptic ulcer, gastritis, esophageal reflux, Zollinger-Ellison syndrome

Front 12

MOA of bismuth

Back 12

Binds to base of ulcers, providing physical protection, and permits HCO3- secretion to reestablish pH gradient in mucosal layer

Front 13

MOA of sucralfate

Back 13

Same as bismuth (protects mucosa, facilitates HCO3- secretion)

Front 14

Triple therapy of H. pylori ulcers

Back 14

Metronidazole, amoxicillin (or tetracycline), bismuth; can also use a PPI
("P.lease M.A.ke T.ummy B.etter")

Front 15

MOA of misoprostol

Back 15

PGE1 analog. Increases mucus, decreases acid in stomach

Front 16

Clinical use of misoprostol

Back 16

Prevention of NSAID-induced peptic ulcers, maintains patent ductus arteriosus, induces labor

Front 17

This GI drug is contraindicated in women of childbearing potential

Back 17

Misoprostol

Front 18

These muscarinic antagonists are used to treat peptic ulcers (rarely)

Back 18

Pirenzepine, propantheline

Front 19

MOA of pirenzepine

Back 19

MI receptor blocker on ECL cells (lowers histamine secretion). M3 receptor blocker on parietal cells (lowers H+ secretion).

Front 20

MOA of propantheline

Back 20

M1 receptor blocker on ECL cells (lowers histamine secretion). M3 receptor blocker on parietal cells (lowers H+ secretion).

Front 21

These drugs cause tachycardia, dry mouth and difficulty focusing eyes

Back 21

Muscarinic antagonists

Front 22

These are the antacids (3)

Back 22

Aluminum hydroxide, magnesium hydroxide, calcium carbonate

Front 23

All antacids have this as their possible side effect

Back 23

Hypokalemia

Front 24

These drugs can affect absorption, bioavailability, or urinary excretion of other drugs

Back 24

Antacids. They delay gastric emptying, and alter gastric pH and urinary pH

Front 25

Side effects of aluminum hydroxide

Back 25

Constipation, hypophosphatemia; proximal muscle weakness, osteodystrophy, seizures
("aluMinimum amount of feces")

Front 26

Side effects of magnesium hydroxide

Back 26

Diarrhea, hyporeflexia, hypotension, cardiac arrest
("Mg=Must go [to the bathroom]")

Front 27

Side effects of calcium carbonate

Back 27

Hypercalcemia, rebound acid increase, chelates other drugs and reduces their effectiveness (eg, tetracyclines)

Front 28

This drug can chelate tetracycline and reduce its effectiveness

Back 28

Calcium carbonate

Front 29

MOA of infliximab

Back 29

Antibody to TNF (TNF is a pro-inflammatory cytokine)

Front 30

Indications for infliximab

Back 30

Crohn's disease, rheumatoid arthritis, ankylosing spondylitis

Front 31

Side effects of infliximab

Back 31

Respiratory infection (including reactivation of latent TB), fever, hypotension

Front 32

This drug can cause reactivation of latent TB

Back 32

Infliximab

Front 33

This drug is activated by colonic bacteria

Back 33

Sulfasalazine

Front 34

MOA of sulfasalazine

Back 34

Combination of sulfapyridine (antibacterial) and mesalamine (anti-inflammatory)

Front 35

This drug is a combination of sulfapyridine and mesalamine

Back 35

Sulfasalazine

Front 36

Indications for sulfasalazine

Back 36

IBD (ulcerative colitis, Crohn's disease)

Front 37

This drug can cause reversible oligospermia

Back 37

Sulfasalazine

Front 38

MOA of ondansetron

Back 38

5-HT3 blocker

Front 39

This drug is a powerful central-acting antiemetic

Back 39

Ondansetron

Front 40

This drug is given to control vomiting postoperatively and in chemotherapy

Back 40

Ondansetron

Front 41

Side effects of ondansetron

Back 41

Constipation, headache

Front 42

MOA of metoclopramide

Back 42

D2 receptor blocker

Front 43

This drug increases resting tone, contractility, lower esophageal sphincter tone, and motility; but does not influence colon transport time

Back 43

Metoclopramide

Front 44

Indications for metoclopramide

Back 44

Gastroparesis (as in diabetics, post-surgical patients)

Front 45

Side effects of metoclopramide

Back 45

Parkinsonian effects

Front 46

This drug is contraindicated in patients with small bowel obstruction

Back 46

Metoclopramide

Front 47

This drug interacts with digoxin and diabetic agents

Back 47

Metoclopramide