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21 Cards in this Set
- Front
- Back
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Humoral Immunity |
Due to ANTIBODIES made by B cells NOCA Neutralization Opsonization Complement activation ADCC |
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Humoral Immunity |
`Eliminates EXTRACELLULAR pathogens `Works with phagocytes and complement `Can be passively transferred |
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Cellular Immunity ~Cellular Immunity is due to.... |
T Cells ` Eliminates INTRACELLULAR pathogens `Transplanted tissue `Cancer `Kills infected host cells `Helps macrophages kill phagocytksed pathogens `Difficult to passively transfer |
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Effector T Cells |
CD8 are KILLER T cells (Tc) CD4 are Helper T cells (Th) |
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Antigen presenting Cells present... |
extracellular antigen on MHC II ---dentritic cells, Macrophages, B cells ....and CD4 T cells bind, then "help" ALL CELLS present intracellular antigen on MHC I ....and CD8 T cells bind, then "kill" |
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MHC Proteins = |
Tissue typing antigens |
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Class I MHC is on all... |
nucleated cells ~ presents antigen or "self" to Tc (CD8) |
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Class II MHC is on... |
professional Antigen Presenting Cells ~ presents antigen on Th1 and Th2 cells (CD4) |
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MHC II and T cells |
MHC I on cells hold "self" molecules ~Bind CD8+ cells ** MHC II on APCs hold the antigen to activate immunity ~APCs come into contact with CD4+ cells to stimulate them ---- MHC II loaded with antigen ---Binds T cell Receptors |
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On the T Cell it is the T Cell Receptor (TCR) that binds ... |
antigen and MHC ---UNLIKE ANTIBODY, the TCR in not secreted; it is always membrane bound --LIKE ANTIBODY, it has a constant region and variable region --ALSO LIKE ANTIBODY, the TCR diversity is also generated by gene cutting and splicing |
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MHC Class I molecules bind to... |
CD8 |
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MHC II molecules bind to... |
CD4 |
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T cell development... |
develop in the thymus --TCR are generated random in those T cells ~TCR must bind MHC I or MHCII for the T cell to survive ---cells that do not bind are signaled to undergo apoptosis |
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Because T cells are selected for their ability to bind self MHC... |
FOREGIN MHC (transplants) tripper T cell rejection ---immature T cells binding too tightly to self peptide on self MHC are also killed |
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T cell immunity |
Tc (cytotoxic (killer) T cells =CD8) recognize and kill virus - infected host cells |
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Th1 cells (= CD4) ... |
signal infected MACROPHAGES to kill pathogens in their phagosomes |
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Th2 cells (=CD4) |
signal B cells to divide and and make anitbodies |
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Cytotoxic T cells (Tc, killer T cell) |
Tc go to the infection site and find and kill virus- infected cells ~ They kill by releasing PERFORIN (makes pores on target cell) and GRANZYMES (cause APOPTOSIS) ~Tc also kill tumor cells |
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Cytotoxicity |
1. CTL recognizes and binds virus-infected cell 2. CTL programs target for death, inducing DNA fragmentation 3. CTL migrates to new target 4. Taret cell dies by apoptosis |
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Skin testing for Th1 function: TB test |
Also called Delayed- Type Hypersensitivity (TB test) ~ Inject small amount of antigen to form bubble under skin |
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B cell activation |
Antigen signal + Th2 signal |
