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Humoral Immunity
Due to ANTIBODIES made by B cells
NOCA
Neutralization
Opsonization
Complement activation
ADCC
`Eliminates EXTRACELLULAR pathogens
`Works with phagocytes and complement
`Can be passively transferred
Cellular Immunity
~Cellular Immunity is due to....
T Cells
` Eliminates INTRACELLULAR pathogens
`Transplanted tissue
`Cancer
`Kills infected host cells
`Helps macrophages kill phagocytksed pathogens
`Difficult to passively transfer
Effector T Cells
CD8 are KILLER T cells (Tc)
CD4 are Helper T cells (Th)
Antigen presenting Cells present...
extracellular antigen on MHC II
---dentritic cells, Macrophages, B cells
....and CD4 T cells bind, then "help"
ALL CELLS present intracellular antigen on MHC I
....and CD8 T cells bind, then "kill"
MHC Proteins =
Tissue typing antigens
Class I MHC is on all...
nucleated cells
~ presents antigen or "self" to Tc (CD8)
Class II MHC is on...
professional Antigen Presenting Cells
~ presents antigen on Th1 and Th2 cells (CD4)
MHC II and T cells
MHC I on cells hold "self" molecules
~Bind CD8+ cells
** MHC II on APCs hold the antigen to activate immunity
~APCs come into contact with CD4+ cells to stimulate them
---- MHC II loaded with antigen
---Binds T cell Receptors
On the T Cell it is the T Cell Receptor (TCR) that binds ...
antigen and MHC
---UNLIKE ANTIBODY, the TCR in not secreted; it is always membrane bound
--LIKE ANTIBODY, it has a constant region and variable region
--ALSO LIKE ANTIBODY, the TCR diversity is also generated by gene cutting and splicing
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