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11 Cards in this Set

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Name one non selective B agonist

SE
isopropterenol

tachycardia due to B1
Name four B2 selective agonists
metaproterenol
terbutaline
albuterol
salmeterol
Terbutaline use
status asthmaticus
(a condition where an asthma attack is refractory to initial bronchodilator therapy)
Salmeterol use

SE (2)
long acting B2 agonist used for
prophylaxis in asthma

tremor and arrhythmia
Theophylline MOA (as well as caffiene)

Why is it a second line agent for asthma
inhibits phosphosiesterase thus increases cAMP
(it also blocks adenosine receptors, which adenosine causes bronchconstriction and inhibits AV nodal conduction)

it mimics any Gs (nervousness, GI disturbances, arrhythmia)
Ipatropium MOA

use (2)
muscasinic antagonist
thus blocks bronchoconstriction (also mucus secretion)

asthma (though adrenergics are better)
COPD
Cromolyn Sodium and Nedocromil MOA
(both administered by inhalation)

use
inhibits mast cell degranulation

prevents asthma attacks (ineffective against acute asthma attacks)
Prednisone use

SE (4)
severe chronic and acute attacks

osteoporosis
hyperglycemia
dysphoria/psychosis
immune suppression
Beclemethasone:
(1st line for chronic asthma)
what is imp about it

MOA

SE
inhaled agent does not get into systemic

inhibits NFkB which decreases TNFa
also decreases release of virtually all cytokines

hoarseness
Zileuton MOA
5 lipooxygenase inhibitor
Zafirlukast MOA
blocks leukotriene receptors (LTD4)