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11 Cards in this Set
- Front
- Back
Name one non selective B agonist
SE |
isopropterenol
tachycardia due to B1 |
|
Name four B2 selective agonists
|
metaproterenol
terbutaline albuterol salmeterol |
|
Terbutaline use
|
status asthmaticus
(a condition where an asthma attack is refractory to initial bronchodilator therapy) |
|
Salmeterol use
SE (2) |
long acting B2 agonist used for
prophylaxis in asthma tremor and arrhythmia |
|
Theophylline MOA (as well as caffiene)
Why is it a second line agent for asthma |
inhibits phosphosiesterase thus increases cAMP
(it also blocks adenosine receptors, which adenosine causes bronchconstriction and inhibits AV nodal conduction) it mimics any Gs (nervousness, GI disturbances, arrhythmia) |
|
Ipatropium MOA
use (2) |
muscasinic antagonist
thus blocks bronchoconstriction (also mucus secretion) asthma (though adrenergics are better) COPD |
|
Cromolyn Sodium and Nedocromil MOA
(both administered by inhalation) use |
inhibits mast cell degranulation
prevents asthma attacks (ineffective against acute asthma attacks) |
|
Prednisone use
SE (4) |
severe chronic and acute attacks
osteoporosis hyperglycemia dysphoria/psychosis immune suppression |
|
Beclemethasone:
(1st line for chronic asthma) what is imp about it MOA SE |
inhaled agent does not get into systemic
inhibits NFkB which decreases TNFa also decreases release of virtually all cytokines hoarseness |
|
Zileuton MOA
|
5 lipooxygenase inhibitor
|
|
Zafirlukast MOA
|
blocks leukotriene receptors (LTD4)
|