Pharm

Front 1

Disulfaram

Back 1

aldehyde dehydrogenase

Front 2

malignant hyperthermia treatment and MOA

Back 2

Dantrolene Na - acts on rinodine Ca2+

Front 3

increased body temperature and muscle rigidity

Back 3

malignant hyperthermia

Front 4

overdose of Midozalam

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Bz - flumazenil

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repetitive behaviour not warranting

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SSRI - fluoxetine , paroxetine, chlomepramine

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Metaclopramide

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vomiting 5HT4 agonist

Front 7

what causes EPS
MOA

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Metaclopramide
blocks D2 receptors

Front 8

given antipsychotic - needs frequent blood work

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Clozampine - agranulocytosis

Front 9

Pt suffering from asthma, seizure disorders -Antidepresant contraindicated in seizures

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Buproprion

Front 10

Elderly patient feeling dizzy - drug causes orthostatic hypotension, pupillary dilatation - 3C coma cardiac arrythmia and convulsion

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alpha receptor blocker
amitriptyline

Front 11

MOA of Bupivocain

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local anaesthsia - block voltage gated Na channels

Front 12

Ethanol for methanol posoining
reaction involved

Back 12

prefered substrate - oxidation

Front 13

bipolar - toxicity and drug used to treat

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LMNOP
nephrogenic diabetes Incipidus
Amiloride

Front 14

diuretic which increases Lithium toxicity

Back 14

thiazide

Front 15

drug and class and MOA causing cogwheel rigidity and muscle stiffness

Back 15

antimania
D2 receptor blocker

Front 16

Epinephrine and lidocain

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vasoconstriction prevent diffusion and prolong duration
decrease systemic effect like bleeding

Front 17

How methadone withdrawal differs from morphine

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less intense but has longer duration than mophine

Front 18

Jaw claaudication and unifacial pain, trigeminal neuralgia DOC

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Carbemazipine

Front 19

light sensitivity , nausea , blurred vision , unilateral headache DOC - MOA

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sumatriptan
seratonin 5HT1d agonist

Front 20

Patient on treatment for parkinson. fluactuating drug

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L dopa

Front 21

L dopa MOA - how to improve fluactuation

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block dopa decarboxylase(L aromatic acid decarboxylase)
-Carbedopa can be given which blocks peripheral and increase central action

Front 22

Drug with muscarinic blockade, dopamine blockade and alpha blockade

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haloperidol , chorpromazine

Front 23

dizziness, nasal stuffness, dry mouth , muscle rigidity , slur speach

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haloperidol , chorpromazine
blocks H-1

Front 24

increased body temperature , autonomic instability, muscle regidity, hypotension

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NMS
neuroleptic malignant syndrom

Front 25

elderly woman on diazepam can't be aroused

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impared renal elimination of diazepam

Front 26

CYP2D6 mutation

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codein cannot be converted to morphine so drug will not be effective

Front 27

What is the effect of CO2 on medullary center

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Stimulant

Front 28

Drug that can block CO2 effect

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Opiod

Front 29

12 year old boy with vocal tics and cop rellelia whats the condition and DOC

Back 29

Tourrettes - Haloperidol

Front 30

Barbituate in general anesthesia - why ultra short acting

Back 30

rapid distribution from brain to fat

Front 31

drug causing gallactorrea in female and breast enlargement in males

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dopamine antagonist( chlopromazine, promethazinethiodazine) - blockage of dopamine increases prolactin levels
antipsychotic

Front 32

increased WBC count , increase CK and body temperature drug causing this and diagnosis

Back 32

Haloperidol
NMS

Front 33

Patient with respiratory depression, coma , constricted pinpoint pupil - condition , drug , MOA

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opiod poisoning - blocks mu receptors
can be reversed by naloxone

Front 34

Ethanol withdrawal

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Chlordiazepoxide - benzo

Front 35

Female couldn't get pregnant treated for mental disorder
class of drug

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Neuroleptic prolactin induce amenorrhea so pt cannot get pregnant due to hyperprolactinemia

Front 36

dilated pupil , agitation , hyperreflexer

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SSRI overdose

Front 37

pt with mental condition treated with a drug causing breast enlargement and galactorrea

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D2 blocker

Front 38

ADR of Al

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constipation

Front 39

ADR Mg

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Diarrhea

Front 40

substernal discomfort (MI)- drug to prevent future attacks

Back 40

Aspirin - block thromboxane A2 production(responsible for platelet aggregation)

Front 41

drug used for bronchial asthma with low effect on heart

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ABEAM
beta 2 selective
albuterol...

Front 42

Pregnant lady with headache and peptic ulcer Drug contraindicated

Back 42

Misoprostol

Front 43

Patient with peptic ulcer and epigastric pain gets relieve from food - class of drug and MOA

Back 43

protein pump inhibitor
inhibits K+H+ ATPase pump
omeprazole

Front 44

DOC for productive cough and MOA

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Acetyle cystein and Na and K citrate
breaks disulphide bonds in sputum

Front 45

management of dry cough
drug and MOA

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codein
acts cough suppression center

Front 46

induce peptic ulcers

Back 46

NSAIDs by inhibiting eiconasoid(prostanglandin)

Front 47

cimetidine and propanolo

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decrease dose of propranolol

Front 48

ketoconazole

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enzyme inhibitor

Front 49

rifampin and barbituates

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enzyme inducers

Front 50

pt on B2 agonist for COPD and its not effective - alternative and why

Back 50

Ipatropium because they don't affect the mucocilliary clearance
DO NOT USE STEROID

Front 51

DOC nasal decongestion

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Phenylephrine
alpha 1 agonist

Front 52

patient on a drug to help in difficulty breathing then suddenly stops

Back 52

phenylephrine
rebound nasal decongestion

Front 53

why is cavidopa given along with L dopa

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inhibit peripheral decarboxylation

Front 54

hyperthyrodism treatment

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tri iodothyrosine
blocks synthesis of thyroid hormone
blocks formation of T3 from T4

Front 55

I 131

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given orally and taken up by nodular cells then emits beta rays which damage cells

Front 56

ADR of I-131
systemic management

Back 56

hypothyroidism
beta blocker

Front 57

converts iodine in diet to organic iodine - organification
treatment

Back 57

peroxidase
block peroxidase - propylthiouracil - no T4 - T3

Front 58

hypothyroidism treatment and complication

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replacement T4 - Liothyronine - given IV
myexedema coma

Front 59

alphacalcidol

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used in pagets - Vit D -

Front 60

4 year old girl operated on with general anesthetic develops increase heart rate and BP -

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Ketamine

Front 61

Pt being treated for nausea and vomiting landed in shuffling gait - treatment

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metoclopamide - D2 blocker

Front 62

Fluoxetine and paroxetine

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SSRI
serotonine specific

Front 63

Patient comes in with smooth shiny tongue - diagnosis and treatment

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pernicious anemia - lack of intrinsic factor - so treat with vit B12

Front 64

Diuretic which can cause breast enlargement

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Spinolactone

Front 65

Rx can increase oral iron absorbtion

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Vit C

Front 66

Rx which can decrease iron absorbtion

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tetracyclin , levadopa

Front 67

withdrawal opiod addict treatment

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naloxone
butorphenol - partial agonist

Front 68

patient comes in with rhinoorhea , lacrimation , goosebumps

Back 68

morphine withdrawal

Front 69

dilated pupils , seizures and history of drug abuse

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amphetamine and cocaine

Front 70

MOR to vancomycin

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changing D ala to D lac
decrease binding to target

Front 71

treatment of trematode worm infestation

Back 71

praziquintel

Front 72

Acyclovir enzyme

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thymidine kinase

Front 73

why are drugs combine in TB

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to delay resistance

Front 74

Strep infection MOA drug

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cell wall synthesis inhibition

Front 75

reistance to macrolide

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methylase enzyme
efflux pump

Front 76

Zirdovine

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inhibits reverse transcriptase - DNA synthesis

Front 77

MOA of mebendazole

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inhibit microtubule synthesis

Front 78

Antiworm infectation drug MOA

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blocks ACH and induces flaccid paralysis

Front 79

hypersensitivity reaction to penicillin

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aztreonam

Front 80

imipenem

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given with cisplatin
cisplatin inhibits renal dehydropeptidase thereby inactivating imipenem

Front 81

DOC HSV

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acyclovir

Front 82

Black water fever

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chloroquine

Front 83

MOA of amphotericin B

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binding to membrane sterol(ergosterl) increase permiability of ions

Front 84

energy dependent efflux - 2 drugs which bacteria develop resistance to

Back 84

macrolides and tetracycline

Front 85

MOA of erythromycin

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motilin receptor stimulation

Front 86

Enzyme inhibited by acyclovir

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DNA polymerase

Front 87

prothetic valve + fungal infection (candida) DOC

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amphoterisin B

Front 88

Zanomivir use and enzyme inhibited

Back 88

Anti influenza -
neuraminidase

Front 89

DOC CMV

Back 89

gangcyclovir

Front 90

Acyclovir resistance HSV

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foscarnet

Front 91

which drug should Ciprofloxacin not be coadministered with

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Al containing antacids because ot reduces bioavailability

Front 92

Patient using charcoal for cooking was rushed to ER - TX

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100% O2

Front 93

child rushed to ER with severe stomach pain and blood in stools. Hx suggest mother is pregnant - mother got Iron supplememnts for pregnancy and child overdosed Rx

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Deferoxamine

Front 94

Kerosine poisoning causes

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aspiration pneumonia if swallowed fumes inhaled

Front 95

Acid toxicity

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peptic ulceration and esophageal rupture

Front 96

Patient on a drug and comes in with breathing difficulties cough and xray shows interstital pulmunary fibrosis

Back 96

Amiodrone

Front 97

smear of blood asking about poisoning

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lead poisoning

Front 98

MOA of steroid causing hyperglycemia

Back 98

increase gluconeogenesis

Front 99

How do you treat a patient suffering from hyperprolactinemia

Back 99

bromocriptine

Front 100

tomoxophine
use and MOA

Back 100

breast cancer
selective estrogen receptor modulator - in cervix and breast it blocks the action of estrogen and stimulates bone and CVS

Front 101

MOA of sulfonoureas

Back 101

at any glucose concentration increases insulin release

Front 102

Pt with cataract, truncal obesity, cushing

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steroids

Front 103

drug which doesn't decrease gastric acid secretion

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sucralfate

Front 104

sweet substance , liquid used in hepatic coma

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lactilose
used in constipation

Front 105

increased HMA and VMA

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pheochromocytoma

Front 106

What happens if dose of propranolol is increased

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increased doses causes saturation of hepatic extraction so increased toxicity.

Front 107

imbalance that causes digoxin toxicity

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hypokalemia

Front 108

in CHF - a diuretic is no longer help what drug can prolong life expectancy

Back 108

ACE inhibitors -prils

Front 109

drug which causes Hypertrichosis

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minoxidil - K channel opener

Front 110

A patient with bronchial asthma is given a drug which causes sudden increase in blood pressure

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pseudoephedrine

Front 111

Pt at rest heart rate is 80, after severe exercise HR 140 then given a drug same exercise but HR only increases to 100

Back 111

beta blocker - pindolol - partial agonisr

Front 112

TCA toxicity

Back 112

dry skin