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16 Cards in this Set
- Front
- Back
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Resp pharm
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resp
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Isoproterenol
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Nonspecific beta-agonist
relaxes bronchial smooth muscle (B2) AE: tachycardia (B1) |
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Albuterol
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Beta2 agonist
relaxes bronchial smooth muscle used in acute exacerbation |
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Salmeterol
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Beta2 agonist
long acting for prohylaxis AE: tremor, arrhythmia |
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Theophylline
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Methylxanthine
causes bronchodilation by inhibiting phosphodiesterase, decerasing cAMP hydrolysis AE: narrow TI, metabolized by P450. Blocks action of adenosine |
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Ipratropium
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Muscarinic antagonist - competative
prevents bronchoconstriction Tx: asthma and COPD |
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Cromolyn
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Prevents release of mediators from mast cells.
Prophylaxis of asthma |
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Corticosteroids
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Inhibit synthesis of all cytokines, inactivates NF-kB, the transcription factor that induces production of TNF-alpha.
1st line therapy for chronic asthma |
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Zileuton
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Antileukotriene
5-lipoxygenase pathway inhibitor, blocks conversion of arachidonic acid to leukotrienes Tx: asthma |
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Zafirlukast, montelukast
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Antileukotrienes
blocks leukotriene receptors. Tx: aspirin-induced asthma |
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Guaifenesin
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Expectorant
removes excess sputum, does NOT suppress cough reflex |
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N-acetylcysteine
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Mucolytic
loosens mucous plugs in CF pts Is an antidote for acetaminophen overdose |
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Drugs associated with interstitial fibrosis
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Amiodarone
Bleomycin Cylclophosphamide Methotrexate |
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Guaifenesin
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Expectorant
removes excess sputum, does NOT suppress cough reflex |
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N-acetylcysteine
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Mucolytic
can loosen mucous plugs in CF pts Is antidote for acetominophen overdose |
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Bosentan
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Competitively antagonizes endothelin-I receptors, decreasing pulmonary vascular resistance
Tx: pulmonary hypertension |
