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629 Cards in this Set
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Dx Criteria for
Psychosis secondary to a general medical condition (3) |
1) Prominent hallucinations
2) Symptoms occur outside delirium 3) Evidence to support medical cause from lab data, hx, or physical |
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Dx Criteria for
Psychosis secondary to medication or substance abuse (4) |
1) Prominent hallucinations
2) Symptoms occur outside delirium 3) Evidence to support medication or substance-related cause from lab data, hx, or phyiscal exam 4) Disturbance is not better accounted for by a psychotic disorder that is not substance-induced |
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Dx Criteria for
Schizophrenia (4) |
1) Two of: Delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, negative symptoms
2) Must cause significant social or occupational functional impairment 3) 6 month duration 4) Sx not due to medical, neurological, or substance induced disorder |
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Dx Criteria for
Schizophreniform disorder |
Schizophrenia symptoms for 1-6 months
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Dx Criteria for
Brief Psychotic Episode |
Schizophrenia symptoms lasting 1 day to 1 month
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Dx Criteria for
Schizoaffective disorder (3) |
1) Have a major depressive, manic, or mixed episode while also meeting criteria for schizophrenia
2) Hallucinations or delusions at least 2 weeks prior to onset of mood disorder 3) Have mood symptoms present for substantial portion of psychotic illness |
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Dx Criteria for
Delusional disorder (2) |
1) Non-bizarre, fixed delusions for at least 1 month
2) Functioning in life not significantly impaired |
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Difference between bizarre and non bizarre delusions
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Non-Bizarre: Beliefs that are false but which are plausible
Bizarre: Basically everything else *Bizarre delusions are pathognomonic for schizophrenia |
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Diagnostic Criteria for Major Depressive Episode (8) |
SIG E CAPS Depressed mood and at least four of the following for 2 weeks: 1) Sleep - Increased/decreased 2) Interest - Anhedonia 3) Guilt - Feelings of worthlessness or guilt 4) Energy - Decreased energy 5) Concentration - Diminished concentration 6) Appetite - Increased or decreased Phycomotor agitation 7) Suicidal ideation |
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Diagnostic Criteria for
Manic Episode |
DIG FAST
A period of abnormally and persistently elevated, expansive, or irritable mood, lasting at least 1 week and including at least 3 of the following (4 if mood is only irritable): 1) Distractibility 2) Insomnia - Decreased need for sleep 3) Grandiosity - or Inflated self-esteem 4) Flight of ideas - or Racing thoughts 5) Activity/Agitation - Increase in goal directed activity (social, sexual, or work) 6) Speech - Pressured speech or talkativeness 7) Thoughtlessness - Excessive activities of indiscretion |
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Diagnostic Criteria for
Mixed Episode |
Meets requirements for both depressive and manic episode
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Diagnostic Criteria for hypomanic Episode (4) |
Meets criteria for a manic episode and: 1) Lasts at least 4 days 2) Does not markedly impair social or occupational functioning 3) Does not require hospitalization 4) No psychotic features |
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Diagnostic Criteria for
Major Depressive Disorder |
At least 1 major depressive episode
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Diagnostic Criteria for
Seasonal Affective disorder |
Major depressive episodes happen during the winter months
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Dx
Irritability, Carbohydrate drawing, and Hypersomnia |
Seasonal Affective disorder
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Drug cause of serotonin syndrome
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An SSRI (usually fluoxetine) with an MAOI
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Dx
Major depression with anhedonia, early morning awakenings, psychomotor disturbance, excessive guilt, and anorexia |
Melancholic Major Depressive disorder
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Dx
Major depression with hypersomnia, hyperphagia, reactive mood, leaden paralysis, and hypersensitivity to interpersonal rejection. |
Atypical Major Depressive disorder
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Dx
Major depression with immobility (catalepsy), purposeless motor activity, extreme negativism or mutism, bizarre postures, and echolalia |
Catatonic Major Depressive disorder
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Dx
Major depression with delusions or hallucinations |
Psychotic Major Depressive disorder
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Dx
Schizophrenia with 1) preoccupation with delusions or auditory hallucinations 2) No predominance of disorganized speech, behavior, of inappropriate affect |
Paranoid Schizophrenia
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Dx
Schizophrenia with 1) Disorganized speech 2) Disorganized behavior 3) Flat or inappropriate affect |
Disorganized Schizophrenia
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Dx
Schizophrenia with at least 2 of: 1) Motor immobility 2) Excessive purposeless motor activity 3) Extreme negativism or mutism 4) Peculiar voluntary movements or posturing 5) Echolalia or echopraxia |
Catatonic Schizophrenia
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Dx
Schizophrenia with 1) Prominent negative symptoms with minimal positive symptoms |
Residual type Schizophrenia
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Dx
Schizophrenia with Multiple subtypes or none |
Undifferentiated Schizophrenia
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Diagnostic Criteria for Bipolar I Disorder (3) |
1) At least 1 manic or mixed episode 2) Can be euthymic, depressed, or hypomanic between frank manic episodes 3) May have psychotic features during either depressive or manic episodes |
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Diagnostic Criteria for Bipolar II Disorder (2) |
1) At least 1 major depressive episode 2) At least 1 hypomanic episode (manic episode excludes) |
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Diagnostic Criteria for
Rapid cycling |
4 or more manic episodes within 1 year
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Diagnostic Criteria for
Dysthymic disorder (3) |
1) Depressed mood for the majority of time of most days for 2 years (in children 1 year)
2) 2 of the following: Poor concentration, hopelessness, poor appetite or overeating, insomnia or hypersomnia, low energy, low self-esteem 3) No euthymia of more than 2 months, and no major depressive episode or (hypo)manic episode |
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Diagnostic Criteria for
Double Depression |
Dysthymic disorder punctuated by major depressive episodes
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Diagnostic Criteria for
Cyclothymic disorder |
1) Numerous periods with hypomanic symptoms and periods with depressive symptoms for at least 2 years
2) No symptom free period greater than 2 years |
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Diagnostic Criteria for
Minor Depressive disorder |
Chronic euthymia punctuated by periods of depressive symptoms that do not meet Major Depressive episode
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Sx of anxiety
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Palpitations
Perspiration Dizziness Mydriasis (pupil dilation) GI discomfort Urinary frequency and urgency |
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Diagnostic Criteria for
Panic Attack (6) |
PANICS
Palpitations Abdominal discomfort Numbness/Nausea Intense fear of death Choking, Chills, Chest pain Sweating, Shaking, SOB |
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Diagnostic Criteria for
Panic Disorder (2) |
1) Spontaneous recurrent panic attacks with no obvious precipitant
2) At least 1 month of persistent concern about having additional attacks, a significant change in behavior related to attacks |
Must specify with or without Agoraphobia
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3 common substances that exacerbate anxiety
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Caffeine
Nicotine Marijuana |
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Tx for
Panic Disorder |
Paroxetine (Paxil)
or Sertraline (Zoloft) Benzos acutely (better than beta blockers) |
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Diagnostic Criteria for
Agoraphobia (2) |
1) Anxiety about being in places from which escape is difficult or where help is not readily available
2) Above are avoided, endured with severe distress, or with a companion |
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Diagnostic Criteria for Specific Phobia (5) |
1) Excessive fear brought on by specific situation or object 2) Exposure to situation or object brings about an immediate anxiety response 3) Pt recognizes fear is excessive 4) Situation is avoided or endured with severe anxiety 5) If pt less than 18, duration must be at least 6 months |
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Diagnostic Criteria for
Social Phobia |
A specific phobia to social settings in which the pt might be embarrassed or humiliated in front of other people
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Tx for Specific Phobia |
Systematic desensitization (Beta blockers or benzos acutely in early desensitization) or flooding |
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Tx for
Social Phobia |
Paroxetine
Beta-blockers for performance anxiety CBT useful adjunct |
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Diagnostic Criteria for Obsessive-Compulsive disorder |
1) a. Obsessions: i. Recurrent and persistent intrusive thoughts or impulses ii. Attempts to suppress thoughts b. Compulsions i. Repetitive behaviors that reduce distress from obsession, but no realistic link between behavior and distress 2. Pt has insight that obsessions and compulsions are unreasonable and excessive 3. Obsessions are distressful, time consuming, or significantly interfere with daily functioning |
Common obsessions and compulsions:1) Contamination and washing2) Doubt and rechecking3) Symmetry 4) Intrusive thoughts wihtout compulsions |
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Tx for
OCD |
High dose SSRI
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Diagnostic Criteria for
Posttraumatic Stress disorder (6) |
1) Having experienced or witnessed a traumatic event.
2) Persistent reexperiencing of event (dreams, flashbacks, recurrent recollections) 3) Avoidance of stimuli associated with event 4) Numbing of responsiveness (diminished affect) 5) Persistent increased arousal (difficulty sleeping, anger, startle response, difficulty concentrating) 6) At least 1 month duration of sx |
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Diagnostic Criteria for Acute Stress disorder |
PTSD sx that last less than 1 month after event |
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Diagnostic Criteria for
Generalized Anxiety disorder (3) |
1) Excessive anxiety and worry about daily events and activities for at least 6 months most days of the week
2) Difficult to control the worry 3) At least 3 of : Restlessness, Fatigue, Difficulty concentrating, Irritability, Muscle tension, Sleep disturbance |
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Diagnostic Criteria for
Adjustment disorder |
1) Emotional or behavioral sx within 3 months of a stressful event that is not life threatening (i.e. divorce):
a. Abnormally elevated distress that impairs daily functioning 2) Not bereavement 3) Last no longer than 6 months after event |
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Diagnostic Criteria for
Personality Disorder |
1) Pattern and behavior/inner experience that deviates from the person's culture and is manifested in two or more of the following ways:
1. Cognition 2. Affect 3. Personal relations 4. Impulse control 2) The pattern: 1. Is Pervasive and inflexible in a broad range of situations 2. Is Stable and has an onset no later than adolescence or early adulthood 3. Leads to significant distress in functioning 4. Is not accounted for by another mental/medical illness or by substance use |
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Diagnostic Criteria for
Paranoid Personality Disorder |
General distrust of others with 4 or more of the following:
1) Suspicion without evidence that others are exploiting or deceiving him or her 2) Preoccupation with doubts of loyalty or trustworthiness of acquaintances 3) Reluctance to confide in others 4) Interpretation of benign remarks as threatening or demeaning 5) Persistence of grudges 6) Perception of attacks on his or her character that are not apparent to others; quick to counterattack 7) Recurrence of suspicions regarding fidelity of spouse or lover |
No fixed delusions or frank hallucinations
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Diagnostic Criteria for
Schizoid Personality Disorder |
A pattern of voluntary social withdrawal and restricted range of emotional expression with 4 or more of the following:
1) Neither enjoying nor desiring close relationships (including family) 2) Generally choosing solitary activities 3) Little if any interest in sexual activity 4) Taking pleasure in few or no activities 5) Few or no close friends or confidants 6) Indifference to praise or criticism 7) Emotional coldness, detachment, or flattened affect |
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Diagnostic Criteria for
Schizotypal Personality Disorder |
Eccentric behavior, cognitive or perceptual distortions, and discomfort with close relationships with 5 or more of the following:
1) Ideas of reference 2) Odd beliefs or magical thinking, inconsistent with cultural norms 3) Unusual perceptual experiences (e.g. bodily illusions) 4) Suspiciousness 5) Inappropriate or restricted affect 6) Odd or eccentric appearance or behavior 7) Few close friends or confidants 8) Odd thinking or speech 9) Excessive social anxiety |
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Diagnostic Criteria for Antisocial Personality Disorder |
Disregard for others and violation of the rights of others since before age 15 with hx of conduct d/o. Pt must be 18 with 3 or more of the following: 1) Failure to conform to social norms by committing unlawful acts 2) Deceitfullness/repeated lying/manipulating others for personal gain 3) Impulsivity/failure to plan ahead 4) Irritability and aggressiveness/repeated fights or assaults 5) Recklessness and disregard for safety of self or others 6) Irresponsibility/failure to sustain work or honor financial obligations 7) Lack of remorse for actions |
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Diagnostic Criteria for
Borderline Personality Disorder |
5 of the following: IMPULSIVE
Impulsive Moody Paranoid under stress Unstable self image Labile, intense relationships Suicidal Inappropriate anger Vulnerable to abandonment Emptiness |
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Diagnostic Criteria for
Histrionic Personality Disorder |
Excessive emotionality and attention seeking with 5 of the following:
1) Uncomfortable when not center of attention 2) Inappropriately seductive or provocative behavior 3) Uses physical appearance to draw attention to oneself 4) Has speech that is impressionistic and lacking in detail 5) Theatrical and exaggerated expression of emotion 6) Easily influenced by others or situation 7) Perceives relationships as more intimate than they actually are |
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Diagnostic Criteria for
Borderline Personality Disorder |
5 of the following: IMPULSIVE
Impulsive Moody Paranoid under stress Unstable self image Labile, intense relationships Suicidal Inappropriate anger Vulnerable to abandonment Emptiness |
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Diagnostic Criteria for
Narcissistic Personality Disorder |
Grandiosity, need for admiration, lack of empathy with 5 of the following:
1) Exaggerated sense of self-importance 2) Preoccupied with fantasies of unlimited money, success, brilliance, etc. 3) Believes that he or she is special or unique and can associate only with other high status individuals 4) Needs excessive admiration 5) Has sense of entitlement 6) Takes advantage of others for self-gain 7) Lacks empathy 8) Envious of others or believes others are envious of him or her 9) Arrogant or haughty |
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Diagnostic Criteria for
Histrionic Personality Disorder |
Excessive emotionality and attention seeking with 5 of the following:
1) Uncomfortable when not center of attention 2) Inappropriately seductive or provocative behavior 3) Uses physical appearance to draw attention to oneself 4) Has speech that is impressionistic and lacking in detail 5) Theatrical and exaggerated expression of emotion 6) Easily influenced by others or situation 7) Perceives relationships as more intimate than they actually are |
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Diagnostic Criteria for
Avoidant Personality Disorder |
Social inhibition, hypersensitivity, and feelings of inadequacy with 4 of the following:
1) Avoids occupation that involves interpersonal contact due to a fear of criticism and rejection 2) Unwilling to interact unless certain of being liked 3) Cautious of intrapersonal relationships 4) Preoccupied with being criticized or rejected in social situations 5) Inhibited in new social situations because he or she feels inadequate 6) Believes he or she is socially inept and inferior 7) Reluctant to engage in new activities for fear of embarrassment |
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Diagnostic Criteria for
Narcissistic Personality Disorder |
Grandiosity, need for admiration, lack of empathy with 5 of the following:
1) Exaggerated sense of self-importance 2) Preoccupied with fantasies of unlimited money, success, brilliance, etc. 3) Believes that he or she is special or unique and can associate only with other high status individuals 4) Needs excessive admiration 5) Has sense of entitlement 6) Takes advantage of others for self-gain 7) Lacks empathy 8) Envious of others or believes others are envious of him or her 9) Arrogant or haughty |
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Diagnostic Criteria for
Dependent Personality Disorder |
Submissive and clinging behavior due to excessive need to be taken care of with 5 of the following:
1) Difficulty making everyday decisions without reassurance from others 2) Needs others to assume responsibilities for most areas of his or her life 3) Cannot express disagreement because of fear of loss of approval 4) Difficulty initiating projects because of lack of self-confidence 5) Goes to excessive lengths to obtain support from others 6) Feels helpless when alone 7) Urgently seeks another relationship when one ends 8) Preoccupied with fear of being left to take care of self |
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Diagnostic Criteria for
Avoidant Personality Disorder |
Social inhibition, hypersensitivity, and feelings of inadequacy with 4 of the following:
1) Avoids occupation that involves interpersonal contact due to a fear of criticism and rejection 2) Unwilling to interact unless certain of being liked 3) Cautious of intrapersonal relationships 4) Preoccupied with being criticized or rejected in social situations 5) Inhibited in new social situations because he or she feels inadequate 6) Believes he or she is socially inept and inferior 7) Reluctant to engage in new activities for fear of embarrassment |
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Diagnostic Criteria for
Obsessive-Compulsive Personality Disorder |
Preoccupation with orderliness, control, and perfectionism at the expense of efficiency with 4 of the following:
1) Preoccupation with details, rules, lists, and organization such that the major point of the activity is lost 2) Perfectionism that is detrimental to the completion of task 3) Excessive devotion to work 4) Excessive conscientiousness and scrupulousness about morals and ethics 5) Will not delegate tasks 6) Unable to discard worthless objects 7) Miserly 8) Rigid and stubborn |
OCD is ego-dystonic
OCPD is ego-systonic |
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Diagnostic Criteria for
Dependent Personality Disorder |
Submissive and clinging behavior due to excessive need to be taken care of with 5 of the following:
1) Difficulty making everyday decisions without reassurance from others 2) Needs others to assume responsibilities for most areas of his or her life 3) Cannot express disagreement because of fear of loss of approval 4) Difficulty initiating projects because of lack of self-confidence 5) Goes to excessive lengths to obtain support from others 6) Feels helpless when alone 7) Urgently seeks another relationship when one ends 8) Preoccupied with fear of being left to take care of self |
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Diagnostic Criteria for
Obsessive-Compulsive Personality Disorder |
Preoccupation with orderliness, control, and perfectionism at the expense of efficiency with 4 of the following:
1) Preoccupation with details, rules, lists, and organization such that the major point of the activity is lost 2) Perfectionism that is detrimental to the completion of task 3) Excessive devotion to work 4) Excessive conscientiousness and scrupulousness about morals and ethics 5) Will not delegate tasks 6) Unable to discard worthless objects 7) Miserly 8) Rigid and stubborn |
OCD is ego-dystonic
OCPD is ego-systonic |
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Diagnostic Criteria for
Substance Abuse |
Impairment or distress for at least 1 year with 1 of the following:
1) Failure to fulfill obligations at work, school, or home 2) Use in dangerous situations 3) Recurrent substance-related legal problems 4) Continued use despite social or interpersonal problems |
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Diagnostic Criteria for
Substance dependence (7) |
3 in a 12 months period:
1) Tolerance 2) Withdrawal 3) Using substance more than originally intended 4) Desire or inability to cut down 5) Significant time spent getting, using, or recovering from substance 6) Decreased social, occupational, or recreational activities bc of use 7) Continued use despite subsequent physical or psychological problems |
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Tx for Acute Alcohol intoxication (4) |
1) Airway, breathing, circulation 2) FSG to r/o hypoglycemia 3) Thiamine to prevent wernicke's encephalopathy 4) Naloxone to reverse effects of any opioids |
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Dx
Insomnia, anxiety, tremor, irritability, anorexia, tachycardia, hyperreflexia, hypertension, fever, seizures, hallucinations, delirium |
EtOH withdrawal
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Timeline of EtOH withdrawal
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Onset: 6-24 hours from last drink
DTs: with 72 hours |
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Tx for
EtOH withdrawal |
1) Benzos
2) Thiamine, folic acid, and a multivitamin 3) Magnesium sulfate for postwithdrawal seizures |
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Dx
Ataxia, Confusion, Ocular abnormalities (nystagmus) |
Wernicke's encephalopathy (thiamine Vit B12 deficiency)
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Dx
Impaired recent memory, anterograde amnesia, confabulation |
Korsakoff's syndrome (untreated Wernicke's encephalopathy of thiamine deficiency)
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Dx
Nausea, dilated pupils, weight loss, psychomotor agitation, chills, and sweating. |
Cocaine intoxication
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Acute medical complications of cocaine intoxication (2)
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MI (from vasospasm)
CVA |
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Tx for
Cocaine intoxication 1. Mild to moderate agitation 2. Severe agitation or psychosis |
1. Mild to moderate agitation - Benzos
2. Severe agitation or psychosis - Haloperidol |
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Dx
Dysphoria, malaise, fatigue, depression, hunger, constricted pupils, vivid dreams, psychomotor agitation or retardation. |
Cocaine withdrawal
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Tx for
Cocaine withdrawal |
Nothing
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Diagnosis, withdrawal, and treatment of what drug class is identical to that of cocaine?
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Amphetamines
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Method of action of
PCP and Ketamine |
NMDA (glutamate) antagonists and dopamine agonists
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Dx
Recklessnes, impulsiveness, impaired judgment, assaultiveness, rotatory nystagmus, hypertension, tachycardia, muscle rigidity, and high tolerance to pain. |
PCP or Ketamine intoxication
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Dx
Rotatory nystagmus |
PCP intoxication
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Date rape drug
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GHB
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Dx
Drowsiness, slurred speech, incoordination, ataxia, mood lability, impaired judgment, nystagmus, respiratory depression. |
Sedative or Hypnotic Intoxication
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Tx for
Benzo intoxication (3) |
1) ABCs
2) Activated charcoal 3) Flumazenil |
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Tx for
Barbiturate Intoxication (3) |
1) ABCs
2) Activated charcoal 3) Sodium bicarb to alkalinize urine to promote renal excretion |
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Tx for
Benzo or barbiturate withdrawal (2) |
1) Long acting benzo taper (CWA protocol)
2) Tegretol or Valproic acid for seizure control |
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Dx
Tachycardia, sweating, insomnia, anxiety, tremor, n/v, delirium, hallucinations. Not EtOH related |
Benzo or Barbiturate withdrawal
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Dx
Drowsiness, n/v, constipation, slurred speech, constricted pupils, seizures, and respiratory depression. |
Opiate intoxication
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Difference between opiates and opioids
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Opiates are naturally occuring (morphine), opioids are synthetic (fentanyl)
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Tx for
Opiate intoxication |
ABCs
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Tx for
Opiate overdose |
Naloxone
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Tx for
Long term opiate dependence |
Methadone or suboxone
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What is the only opiate that dilates pupils?
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Demerol (Meperidine)
"Demerol dilates pupils" |
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Dx
Dysphoria, insomnia, lacrimation, rhinorrhea, yawning, weakness, sweating, piloerection, n/v, fever, dilated pupils, muscle ache. |
Opiate withdrawal
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Tx for
Opiate withdrawal Moderate - Severe - |
Moderate - Clonidine or Buprenorphine
Severe - Methadone taper |
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Dx
Perceptual changes, papillary dilation, tachycardia, tremors, incoordination, sweating, palpitations. |
Hallucinogen intoxication
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Tx for
Hallucinogen intoxication |
Talking down pt, possibly antipsychotics
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Dx
Euphoria, impaired coordination, mild tachycardia, conjunctival injection, dry mouth, increased appetite. |
Marijuana intoxication
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Dx
Impaired judgment, belligerence, impulsivity, perceptual disturbances, lethargy, nystagmus, tremor, muscle weakness, ataxia, slurred speech, euphoria, stupor, or coma. |
Inhalant intoxication
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Tx for
Inhalant intoxication |
ABCs
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Tx for
Marijuana intoxication |
None
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Dx
Anxiety, insomnia, twitching, rambling speech, flushed face, diuresis, GI discomfort, and restlessness. |
Caffeine intoxication
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Dx
Tinnitus, severe agitation, and cardiac arrhythmias. |
Caffeine overdose
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Dx
Headache, n/v, drowsiness, anxiety or depression. |
Caffeine withdrawal
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Dx
Improved attention, improved mood, decreased tension, insomnia, restlessness, anxiety, GI discomfort. |
Nicotine intoxication
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Dx
Craving, dysphoria, anxiety, increased appetite, irritability, insomnia. |
Nicotine withdrawal
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Minimum workup to exclude reversible causes of dementia (6)
15% of dementia |
1) CBC
2) Panel 7 3) Thyroid function tests 4) RPR 5) B12 and folate 6) Brain CT or MRI |
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Dx
Dementia with stepwise increase in severity and focal neurological signs |
Multi-infarct dementia
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Dx study for
Multi-infarct dementia |
Head CT/MRI
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Dx
Dementia, cogwheel rigidity, resting tremor |
Lewy body dementia or
Parkinson's disease |
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Dx
Dementia, atraxia, urinary incontinence, dilated cerebral ventricles |
Normal pressure hydrocephalus
(Wild, wet, and wobbly) |
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Dx study for
Normal pressure hydrocephalus |
Head CT/MRI
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Dx
Dementia, obesity, coarse hair, constipation, cold intolerance |
Hypothyroidism
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Dx
Dementia, diminished position and vibration sensation, megaloblasts on CBC |
Vitamin B12 deficiency
(Posterior column disease) |
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Dx
Dementia, tremor, abnormal liver function tests, Kayser-Fleischer rings |
Wilson's disease
(Too much copper) |
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Dx
Dementia, diminished position and vibration sensation, Accomodation Response Present, response to light absent |
Neurosyphilis
Argyll-Robertson pupils (Accomodation Response Present but response to light absent) ARP, get it |
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Two types of delirium
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Quiet delirium: Depressed, failure to thrive
Agitated: Pulling out lines, may be hallucinating |
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Tx for
Delirium |
Quetiapine (seroquel) or
Haloperidol |
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Differential Diagnosis for
Delirium |
AEIOU
Alcohol Electrolytes Iatrogenic (medications) Oxygen hypoxia (bleeding, pulmonary cause) Uremia/hepatic encephalopathy |
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Dx Criteria for
Alzheimer's Dementia (4) |
Memory impairment plus 1:
1) Aphasia - Disorder of language affecting speech and understanding 2) Apraxia - Inability to perform purposeful movements 3) Agnosia - Inability to interpret sensations correctly (i.e. inability to recognise an object) 4) Diminished executive functioning - problems with planning, organizing, and abstracting |
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Neurophysiologic chagnes in
Alzheimer's Dementia (2) |
1) Decreased ACh (due to loss of noradrenergic in Locus Ceruleus of brainstem)
2) Decreased Norepi (due to loss of cholinergic neurson in Basal Nucelus of Meynert) |
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Microscopic changes in
Alzheimer's Dementia |
1) Senile plaques from amyloid Beta protein
2) Neurofibrillary tangles from Tau protein |
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Tx for
Early Alzheimer's Dementia |
Donepezil (Aricept)
Cholinesterase inhibitor |
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Tx for
Anxiety in dementia |
Low dose, short acting benzos
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Tx for
Agitation or psychosis in dementia |
Quetiapine
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Dx Criteria for
Vascular Dementia (4) |
Memory impairment with 1)
1) Aphasia 2) Apraxia 3) Agnosia 4) Diminished executive functioning |
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Dx Criteria for
Mild Cognitive Impairment |
Normal daily function but abnormal memory functioning relative to age
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Dx
Aphasia, apraxia, agnosia, with personality and behavior changes usually before memory impairments |
Frontotemporal Dementia (Pick's Dementia)
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Microscopic finding in
Frontotemporal Dementia |
Pick bodies (tau protein)
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Dx
Progressive dementia, bizare choreiform movements, muscular hypertonicity |
Huntington's Disease
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Dx
Bradykinesia, cogwheel rigidity, resting tremor, masked facies, shuffling gait, dysarthria |
Parkinson's Disease
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Neurophysiology of
Parkinson's Disease |
Neuronal loss in Substantia Nigra causing decreased Dopamine to Basal Ganglia
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Tx for
Parkinson's Disease |
Levodopa and Carbidopa
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Dx
Rapidly progressive dementia, 6-12 months after onset of sx, startle myoclonus and possibly ataxia and fasciculations. |
Creutzfeld-Jakob
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Dx Criteria for
Creutzfeld-Jakob |
1) Rapidly progressive dementia
2) Periodic generalized sharp waves on EEG 3) At least 2 of: a. Myoclonus b. Cortical blindness c. Ataxia, pyramidal signs, or EPS d. Mutism |
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Tx
Normal Pressure Hydrocephalus |
Shunt to decrease ICP
(Yes, contrary to name the pressure is elevated) |
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Dx
Delirium with hemiparesis or other focal neurological signs and symptoms |
CVA or mass lesion
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Dx
Delirium, elevated blood pressure, papilledema |
Hypertensive encephalopathy
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Dx
Delirium, dilated pupils, tachycardia |
Drug intoxication
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Dx
Delirium, fever, nuchal rigidity, photophobia |
Meningitis
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Dx
Delirium, tachycardia, tremor, thyromegaly |
Thyrotoxicosis
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Dx
Impairment of memory without other cognitive impairment or altered consciousness. |
Amnestic disorder
(Hypoglycemia, CVA, seizure, MS, etc) |
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Dx
Decreased muscle mass/increased fat, decreased brain mass with enlarged ventricles, impaired vision and hearing, minor forgetfullness |
Normal Aging
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Stages of Dying (5)
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1) Denial
2) Anger 3) Bargaining 4) Depression 5) Acceptance |
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Dx
Memory and cognitive impairment, emphasizes failures, no sundowning, patient has insight. |
Pseudodementia
i.e. Depression in the elderly |
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Tx for
Depression in elderly |
SSRIs
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Tx for
Depression in elderly with insomnia and decreased appetite |
Mirtazapine (Remeron)
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Tx for
Depression in elderly on top of SSRI for psychomotor retardation |
Methylphenidate
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Criteria for grief to be pathological (4)
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1) Weight loss
2) Hallucinations or delusions (not illusions) 3) Suicidal ideation 4) Sx for more than 1 year |
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Dx Criteria for
Mental Retardation |
1) IQ less than 70
2) Onset before 18 |
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Dx Criteria for
Learning Disorder |
Lower than expected achievement in reading, math, or writing than would be expected given age, level of education, and level of intelligence.
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Dx Criteria for
Conduct Disorder |
Violation of the basic rights of others with 3:
1) Aggression towards people or animals 2) Destruction of property 3) Deceitfulness 4) Serious violation of rules or laws |
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Dx Criteria for
Oppositional Defiant Disorder |
6 months of negativistic, hostile, defiant behavior with 4:
1) Frequent loss of temper 2) Arguments with adults 3) Deliberately annoying people 4) Easily annoyed 5) Anger and resentment 6) Blaming others for mistakes or misbehaviors |
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Difference between ODD and Conduct Disorder
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ODD does not violate the basic rights of others and children frequently get along with peers but not with authority figures.
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Dx Criteria for
ADHD (2) |
1) 6 Sx of inattentiveness, hyperactivity, or both for at least 6 months
2) Onset before 7 |
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Dx Criteria for
Autism |
6 of:
1) Impairment in nonverbal behaviors (facial expressions etc) 2) Failure to develop peer relationships 3) Failure to seek enjoyment from others 4) Lack of social or emotional reciprocity 5) Lack of or delayed speech 6) Repetitive use of language 7) No imaginative play 8) Inflexible rituals 9)Repetitive movements 10) Preoccupation with parts of objects |
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Dx Criteria for
Asperger's Disorder |
Autism without language delays
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Dx
Diminished head circumference, stereotyped hand movements, cognitive development halted at 1 year, girl |
Rett's syndrome
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Dx Criteria for
Disintegrative Disorder |
1) Normal development in first 2 years
2) Loss of acquired skills in at least two of: Language, social skills, bowel or bladder control, play, motor skills 3) At least 2: Impaired social interaction, impaired use of language, restricted, repetitive, and stereotyped behaviors and interests |
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Dx
Multiple daily motor and vocal tics with onset before 18. |
Tourette's Disorder
Otherwise a motor or vocal tic in isolation |
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Dx
Bedwetting |
Enuresis
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Tx for
Enuresis |
Antidiuretics or TCAs
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Dx
Inappropriate bowel movements for 3 months at least once a month |
Encopresis
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Dx
Inability to recall important personal information usually involving a traumatic or stressful event, but can remember obscure details |
Dissociative Amnesia
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Dx
Sudden, unexpected travel away from home, accompanied by the inability to recall parts of one's past or identity, usually undertaking a new identity and having no insight. |
Dissociative Fugue
Usually only lasts a few days, pt will not remember fugue episode |
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Dx Criteria for
Dissociative Identity Disorder (Multiple Personality Disorder) |
1) Presence of two or more distinct identities which consistently overtake the person's behavior
2) Inability to recall personal information of one personality when the other is dominant |
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Dx
Persistent or recurrent feelings of detachments from one's self, environment, or social situation. Out of body experiences. |
Depersonalization Disorder
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Tx for
Depersonalization Disorder |
SSRI
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Difference between primary and secondary gain
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Primary gain - Expression of unacceptable feelings as physical symptoms in order to avoid facing them.
Secondary gain - Use of symptoms to benefit the patient, money, meds, or worker comp, etc. |
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What is a somatoform disorder?
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Patients with physical symptoms that have no organic cause. The patient's pain is real and is not faking (which would be malingering).
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Dx
Multiple vague complaints involving many organ systems without an underlying organic cause and resistant to psychiatric referral. |
Somatization disorder
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Dx
Patient initiates or exacerbates a true neurological symptom bc of a psychological symptom. Examples include shifting paralysis, blindness, mutism, paresthesias, seizures. Usually spontaneously recover. |
Conversion Disorder
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Dx
Prolonged, exaggerated concern about health and potential illness. |
Hypochondriasis
Pts with hypochondriasis worry about having disease, whereas pts with somatization disorder complain about the symptoms. |
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Dx
Preoccupied with body parts that they deem as ugly or unsightly but which are normal. |
Body Dysmorphic Disorder
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Tx for
Body Dysmorphic Disorder |
SSRIs
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Dx
Prolonged, severe discomfort, usually co-existent with a medial condition but not directly caused by it. |
Pain Disorder
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Dx
Intentional feigning or artificially causing of medical symptoms in order to assume role of sick patient |
Factitious Disorder
(Munchhausen Syndrome) Munchhausen can be by proxy if you force your kid to be sick role |
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Dx
Feigning of physical or psychological symptoms for personal gain. |
Malingering
Different than Factitious in that factitious has no obvious external reward |
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Dx
Failure to resist aggressive impulses that result in assault or property destruction |
Intermittent Explosive Disorder
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Dx
Urge to steal when not needed for personal use. |
Kleptomania
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Dx
Intentional fire setting not for monetary gain, or expression of anger. |
Pyromania
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Dx
Recurrent pulling out of one's hair. |
Trichotillomania
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Dx Criteria for
Anorexia Nervosa (3) |
1) Body weight less than 85% ideal
2) Intense fear of gaining weight or being fat 3) Disturbed body image |
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Indication for inpatient treatment of Anorexia (3)
|
1) Electrolyte disturbances
2) Less than 80% ideal body weight 3) Arrhythmias |
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Dx Criteria for
Bulimia Nervosa (3) |
1) Recurrent episodes of binge eating
2) Compensating behavior 3) Binge and compensation happen sx per week for 3 months |
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Dx Criteria for
Binge Eating Disorder |
1) Recurrent binge eating
2) Severe distress over binging 3) Binging 2x/week for 6 months 4) Fast, full, furtively, fallen (feeling disgusted) |
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Difference between Dyssomnias and Parasomnias
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Dyssomnias - disturbances in amount, quality, or timing of sleep
Parasomnias - Abnormal events in behavior or physiology during sleep |
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Dx
Difficulty initiating or maintaining sleep resulting in daytime drowsiness or difficulty fulfilling tasks. |
Primary Insomnia
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Tx for
Primary Insomnia |
Sleep hygiene
Meds: Benadryl, Zolpidem, Zaleplon, Trazodone |
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Dx
At least 1 month of excessive daytime sleepiness or excessive sleep. |
Primary Hypersomnia
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Dx
1) Cataplexy - collapse due to loss of muscle tone associated with emotion especially laughter (70% of pts) 2) Short REM latency 3) Brief paralysis upon awakening (50%) 4) Hypnagogic (falling asleep), or hyponopompic (waking up) hallucinations (30%) |
Narcolepsy
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Tx for
Narcolepsy (2) |
Timed daily naps plus stimulants
SSRIs for cataplexy |
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Dx
HAs, depression, pulmonary HTN |
Breathing Related Sleep Disorder
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Dx
Disturbance due to circadian sleep wake cycles |
Circadian Rhythm Sleep Disorder
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Dx
Repeated awakenings from REM with recall of extremely frightening dreams that causes significant distress |
Nightmare Disorder
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Dx
Repeated episodes of fearfullness during early hours of sleep from which patient does not awaken. |
Night Terror Disorder
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Dx
Repeated episodes of ambulation or other activity while sleeping that are not remembered. |
Somnambulism
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Neurotransmitters in libido
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Dopamine increases libido (antipsychotics are inhibitory)
Serotonin decreases libido (SSRIs are inhibitory) |
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Dx
Absence or deficiency of sexual desires or fantasies |
Hypoactive sexual desire disorder
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Dx
Avoidance of sexual contact with a sexual partner |
Sexual aversion disorder
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Dx
Inability to attain an erection |
Male Erectile Disorder (primary if never in life; secondary if lost the ability)
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Dx
Inability to maintain lubrication until completion of sex act (33% of women) |
Female Sexual Arousal Disorder
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Dx
Inability to achieve orgasm |
Orgasmic disorder (30% of women)
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Dx
Genital pain before, during, or after intercourse |
Dyspareunia
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Dx
Involuntary muscle contraction of the outer third of vagina upon insertion |
Vaginismus
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Dx
Sexual preference for inanimate objects |
Fetishism
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Dx
Sexual gratification from wearing opposite gender's clothing |
Transvestic Fetishism
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Dx
Sexual pleasure in rubbing genitals against unsuspecting people |
Frotteurism
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Dx
Sexual excitement from being humiliated or beaten |
Masochism
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Dx
Sexual excitement from hurting or humiliating others |
Sadism
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Dx
Sexual excitement form calling unsuspecting strangers and engaging in sexual conversations |
Telephone scatalogia
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Dx
Subjective feeling the patient was born the wrong sex. |
Gender Identity Disorder (aka Transsexuality)
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What are the Mature Defense
Mechanisms? (4) |
HASS
Humor Altruism Sublimation Suppression |
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What are the Neurotic Defense Mechanisms? (7)
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CDI2R3
Controlling - regulating situations Displacement - Shifting emotions from situation or person to another Intellectualization - Isolation of Affect - Unconsciously limiting the experience of feeling or emotions associated with a stressful life event Rationalization - Conjuring explanations of an event in order to justify outcomes or behaviors Reaction Formation - Doing the opposite of an unacceptable impulse Repression - Preventing a thought or feeling from entering unconscious (repression in unconscious whereas suppression is conscious) |
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What are the Immature Defense Mechanisms? (4)
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DRAP
Denial Regression - to an earlier state of development Acting Out - Giving in to impulse in order to avoid anxiety of suppressing it Projection - Attributing one's own objectionable thoughts or emotions to others (Claiming other people have acted on your impulses) |
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Other defense mechanisms (2)
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Splitting
Undoing - attempting to reverse situation by doing a new behavior |
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Elements of informed consent (4)
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1) Name and purpose of treatment
2) Potential risks and benefits 3) Alternatives to the treatment 4) Consequences of refusing the treatment |
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Requirements to be not guilty by insanity (3)
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1) Have a mental illness
2) Not understand right from wrong 3) Not understand consequences of action at time of act |
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4 D's of malpractice
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Dereliction of a Duty that lead Directly to Damages
Compensatory damages are reimbursement for expenses, lost income, or for physical suffering. Punitive damages are reimbursements to the patient to punish the doctor for gross negligence or carelessness. |
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Citalopram
-Brand name -MOA -s/e -Indications |
-Brand name: Celexa
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Escitalopram
-Brand name -MOA -s/e -Indications |
-Brand name: Lexapro
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Fluoxetine
-Brand name -MOA -s/e -Indications |
-Brand name: Prozac
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Fluvoxamine
-Brand name -MOA -s/e -Indications |
-Brand name: Luvox
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Paroxetine
-Brand name -MOA -s/e -Indications |
-Brand name: Paxil
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Sertraline
-Brand name -MOA -s/e -Indications |
-Brand name: Zoloft
-MOA: SSRI -s/e: 5HT2A/C: Anxiety, insomnia, sexual dysfunction 5HT3/4: GI upset -Indications: Depression and Anxiety |
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Desipramine
-Brand name -MOA -s/e -Indications |
-Brand name: Norpramin
-MOA: SNRI -s/e: Anti-H: Sedation, weight gain Anti-A: Orthostatic hypotension, dizziness, falls Anti-M: Drymouth, sedation, constipation, urinary retention, blurry vision Anti-Na channel: Arrhythmia -Indications: Mood, Anxiety, Alertness |
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Method of action of TCAs
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Serotonin and Norepinephrine reuptake inhibitors
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Nortryptiline
-Brand name -MOA -s/e |
-Brand name: Pamelor
-MOA: SNRI -s/e: Anti-H: Sedation, weight gain Anti-A: Orthostatic hypotension, dizziness, falls Anti-M: Drymouth, sedation, constipation, urinary retention, blurry vision Anti-Na channel: Arrhythmia (prolonged QT) -Indications: Mood, Anxiety, Alertness |
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Amoxapine
-Brand name -MOA -s/e |
-Brand name: Asendin
-MOA: SNRI -s/e: Anti-H: Sedation, weight gain Anti-A: Orthostatic hypotension, dizziness, falls Anti-M: Drymouth, sedation, constipation, urinary retention, blurry vision Anti-Na channel: Arrhythmia -Indications: Mood, Anxiety, Alertness |
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Atomoxetine
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Strattera
-MOA: Selective Norepinephrine reuptake inhibitor -s/e: Urinary retention -Indications: Add to SSRI for Norepi profile |
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Reboxetine
-MOA: -s/e: -Indications: |
-MOA: Selective Norepinephrine reuptake inhibitor
-s/e: Urinary retention -Indications: Add to SSRI for Norepi profile |
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Venlafaxine
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Effexor
-MOA: SNRI Low dose - mostly serotonin High dose - mostly NE -s/e: HTN -Indications: Mood, Anxiety, Alertness |
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Phenelzine
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Nardil
-MOA: MAOI - Serotonin, NE, and Dopamine reuptake inhibitor -s/e: Tyramine restriction, weight gain, sedation -Indications: Mood |
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Tranylcyrpromide
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Parnate
-MOA: MAOI - Serotonin, NE, and Dopamine reuptake inhibitor -s/e: Tyramine restriction, weight gain, sedation -Indications: Mood |
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Isocarboxazid
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Marplan
-MOA: MAOI - Serotonin, NE, and Dopamine reuptake inhibitor -s/e: Tyramine restriction, weight gain, sedation -Indications: Mood |
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Mirtazapine
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Remeron
-MOA: Alpha 2 agonist causing increased Serotonin and NE, also blocks 5HT2A/C, H5T3, and 5HT4 -s/e: Sedation, weight gain (blocking 5HT2 relieves insomnia but causes sedation) -Indications: Depression especially with weight loss or insomnia |
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Nafazodone
-Brand name: -MOA: -s/e: -Indications: |
-MOA: 5HT2 antagonist (which indirectly agonizes 5HT1)
-s/e: -Indications: Depression, no sexual side effects |
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Trazodone
-Brand name: -MOA: -s/e: -Indications: |
-MOA: 5HT2 antagonist (which indirectly agonizes 5HT1)
-s/e: Priapism, weight gain and sedation -Indications: Sleep aid, no sexual side effects |
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Bupropion
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Wellbutrin
-MOA: DNRI, Dopamine and NE reuptake inhibitor -s/e: Seizures in anorexics with IR formula -Indications: Add to SSRI to relieve sexual dysfunction, depression, ADHD, Cigarette cessation |
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Buspirone
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Buspar
-MOA: 5HT1A partial agonist, also increases amount of serotonin in neurons by improving recycling -s/e: none -Indications: GAD |
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Duloxetine
-Brand name: -MOA: -s/e: -Indications: |
-Brand name: Cymbalta
-MOA: TCA - 5HT and NE reuptake inhibitor -s/e: Sedation, weight gain -Indications: Depression and neuropathic pain |
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Tx for
Delirium |
Haloperidol
(High potency has no effect on CV or respiratory drive; do not use low potency bc anti-ACh worsens delirium, lowers seizure threshold, and causes hypotension) |
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Tx for
Tourette's |
Haloperidol
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Clozaril
Brand name: MOA: s/e: Special considerations: |
Brand name: Clozapine
MOA: D2, 5HT2A, HAM antagonist s/e: Wt gain, sedation, constipation, decreased seizure threshold tachycardia, hypotension Special considerations: a. Can cause Agranulocytosis! so bi-weekly CBCs b. Increased salivaiton |
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Olanzapine
Brand name: MOA: s/e: Special considerations: |
Brand name: Zyprexa
MOA: Blocks D2, 5HT2A, HAM s/e: Wt gain, diabetes, sedation, dizziness Special considerations: Lots of weight gain, otherwise a great drug |
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Ziprasidone
Brand name: MOA: s/e: Special considerations: |
Brand name: Geodon
MOA: Blocks D2, 5HT2A, HA s/e: Sedation, prolonged QTc Special considerations: Least likely to cause weight gain |
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Risperidone
Brand name: MOA: s/e: Special considerations: |
Brand name: Risperdal
MOA: Blocks D2 and 5HT2A (the latter mitigates the EPS sx) s/e: Galactorrhea, sexual dysfunction, hypotension, tachycardia, sedation, wt gain, insomnia, decreased concentration Special considerations: Least anti-M activity |
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Quetiapine
Brand name: MOA: s/e: Special considerations: |
Brand name: Seroquel
MOA: Lower affinity for blocking D2 and 5HT2A, blocks HA s/e: Sedation, hypotension, insomnia, dry mouth Special considerations: 1st line atypical bc no EPS without blood draws. Less weight gain, no prolactin elevation. |
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Psychological test for
Depression and/or Anxiety |
Beck Depression Inventory
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Psychological test for
short term memory (as for ECT s/e) |
Brown-Peterson Task
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Psychological test for
ADLs in moderate to severe dementia |
Geriatric Rating Scale
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Psychological test for
Dementia (2) |
Mini Mental Status Exam (MMSE)
or Montreal Cognitive Assessment (MOCA) |
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Psychological test for
Level of consciousness |
Glasgow Coma Scale
|
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Psychological test which
Asks patient's friends and relatives about their functional ability in their current environment |
Blessed Rating Scale
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|
Which psychiatric illness can look like dementia in elderly patients?
|
Depression
(Pseudodementia) |
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What does the Wisconsin Cart Sorting Test?
And what disease is it useful for? |
-Executive functioning (frontal lobe)
-Schizophrenics perform worse than normal as do people with frontal lobe damage |
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Indications for Draw a Person Test?
|
Brain damage
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What does Bender Gestalt test indicate?
|
Organic causes of brain disease
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|
Rorschach, Thematic Apperception Test, Sentence Completion Test, and Draw a Person test are all testing what?
|
Personality
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Projective tests are based on activity.
Rorschach and Word Association Test - TAT - Draw a Person - Sentence Completion Test - |
Rorschach and Word Association Test - Associations
TAT - Construction Draw a Person - Expression Sentence Completion Test - Completion |
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What does the Stroop Test
|
Concentration
(reading words in different colors) |
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What does the Fargo Map test?
|
Recent and remote spatial memory (basically a geography test)
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What does the Rey-Osterrieth test show?
|
Redrawing figure with picture and from memory to assess visual spatial nonverbal memory.
-Right parietal lesion -->ignore left part of picture -Right temporal lesion --> no problems copying, but cannot redraw from memory |
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What does the Boston Diagnostic Aphasia Examination show?
|
Evaluate aphasic disorders and speech problems (i.e. after stroke)
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What does the serial 7s or world backward test?
|
Concentration
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|
A defense mechanism that uses elaborate and reassuring explanations that avoid the actual underlying motives.
|
Rationalization
|
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|
A defense mechanism that deals with stressors by breaking down the usual integration of memory, behavior, and perception.
|
Dissociation
|
|
|
A defense mechanism that utilizes reflecting on one's own thoughts and behaviors with appropriate responses.
|
Self-observation
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|
Something should be familiar but appears novel and unfamiliar
|
Jamais vu
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|
Feeling that you have heard this before
|
Deja Entendu
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|
Feeling that you have seen this before
|
Deja vu
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|
A defense mechanism that utilizes the formation of thoughts that are opposite to the anxiety provoking feelings
|
Reaction formation
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|
A defense mechanism that transfers a feeling toward an object or person that is less threatening.
|
Displacement
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|
The recurrence of Sx after abrupt cessation.
|
Rebound
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|
The long term return of the original symptoms
|
Recurrence
|
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|
Test used to quantitate the Rorschach
|
Exner Comprehensive System
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|
What does the Random Letter test?
|
Concentration, cooperation, and hearing
|
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|
Test to determine prior to ECT the hemisphere in which Language is
|
Wada Test
(Inject sodium amytal to anesthetize hemispheres one at a time and look for aphasia) |
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|
What is the rate of teenage suicide attempts and who are more likely to succeed?
|
9% of all have attempted.
Boys 5x more likely than girls to succeed. |
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|
Most frequent suicide attempt method, and most frequent method of success?
|
OD is most common, but firearms are far more likely to succeed so account for more total deaths
|
|
|
Strategies for questioning
|
Do not use "but"
Express concern Use an open ended question |
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|
In what sleep stage does sleep terror and sleep walking happen?
|
3 and 4 (not REM)
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|
First line Tx for
MDD in children and adolescents? |
SSRI
|
|
|
1st line Tx for
Bulimia Nervosa |
CBT
|
|
|
Dx
Markedly limited vocabulary, tense errors, undeveloped sentences, interferes with academic function |
Expressive Language Disorder
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|
Dx study for suspected
Expressive language disorder |
IQ test (to rule out mental retardation)
|
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|
Dx
Baby not gaining weight after period of nl development, drooling a lot, lots of caretakers |
Rumination disorder
Baby regurgitates and then chews on food |
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|
Dx study for
Rumination disorder |
Esophageal pH measurement (to rule out gastric reflux)
|
|
|
Dx
Child does not like school, sleeps in parents bed, repeated physical sx at school |
Separation anxiety disorder
|
|
|
Dx
Emotional concerns manifest as physical symptoms |
Somatization (defense mechanism)
|
|
|
Dx
Repeated speaking of obscene words |
Coprolalia (as in severe Tourette's)
|
|
|
Dx
Eating of feces |
Coprophagia
|
|
|
Dx
Defense mechanism in which an unacceptable impulse is transformed into its opposite |
Reaction Formation
|
|
|
Most common cause of psychosis in children?
|
Substance induced
|
|
|
Most common psychiatric emergency in children and adolescents?
|
Suicide
|
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|
What axis is stuff that has psychological and environmental problems that affect the diagnosis, treatment, or prognosis of Axis I?
|
Axis IV
II is personality and MR III is medical V is GAF |
|
|
Common differences in MDD in children and adolescents?
|
Kids have PMA
Teens have hypersomnia, hopelessness, weight change, and drug abuse. |
|
|
s/e of
Antidiuretic hormone |
Headache and nausea
|
|
|
Laboratory abnormality in antidiuretic use for enuresis
|
Hyponatremia
|
|
|
Comorbidity rate of anxiety disorders and MDD in children
-with ADHD |
50%
ADHD = 30% |
|
|
Tx for
Lead toxicity - Iron toxicity - Acetaminophen toxicity - |
Lead toxicity - CaEDTA
Iron toxicity - Deferoxamine Acetaminophen toxicity - Acetylcysteine |
|
|
Dx
Deceleration of head growth, loss of hand skills, stereotyped hand movements, poor gait, and severely impaired expressive and receptive language development with PMR |
Rett syndrome
|
|
|
Common associations with CD.
|
ADHD and substance abuse
|
|
|
Explain adjustment disorder
|
Happens after an event within 3 months but lasts no more than 6, looks like depression.
|
|
|
Tx for
Tourette's |
Clonidine is first line
Haldol has better evidence but is now second line |
|
|
Interview strategy for 7 yo boy
|
Play interview
|
|
|
Psychiatric illness should be aggressively treated in children with medical illness as it improves medical outcomes.
|
!
|
|
|
First sx in
Tourette's |
Blinking and eye rolling first
then grunting, grimacing, and licking |
|
|
Dx criteria for Tourette's
|
Multiple motor tics and at least one vocal tic before 18 yo
|
|
|
Most common time period for MR to develop
|
Early embryonic development (s'somal abnls and prenatal damage)
|
|
|
Dx criteria for
Disruptive behavior disorder NOS |
Meets some but not enough criteria for CD or ODD and causes impairment
|
|
|
Which drugs can predispose to tics
|
Stimulants
|
|
|
Most commonly associated with learning disorders?
|
ADHD
|
|
|
High school drop out rate for learning disabled?
|
40%
|
|
|
Tx for
Enuresis |
Imipramine
|
|
|
Efficacy of stimulants for ADHD
|
70%
|
|
|
Milestones:
Copy circle - Age and gender, ride tricycle - Copy square and identify hands - |
Copy circle - 2
Age and gender, ride tricycle - 3 Copy square and identify hands - 5 |
|
|
Dx
Impaired social interactions and attachments, restricted interests and behaviors, impaired communication |
Autism
|
|
|
Best prognostic indicator for Autism
|
Converse meaningfully with others
|
|
|
Dx
Hypercholesterolemia, hypercarotenemia (yellowing of skin), no change in TSH |
Anorexia Nervosa
|
|
|
Dx
Increased ventricular brain ratios, sinus brady |
Anorexia Nervosa
|
|
|
Stranger anxiety is normal and abnormal when?
|
Normal in 8 month old
Absently abnormal in autistics |
|
|
Most helpful distinction between mania and ADHD in children?
|
ADHD kids have low self esteem as opposed to grandiosity
|
|
|
Age at which death can be appreciated
|
6-10 yo
|
|
|
Defense mechanism in which a thought, impulse or effect is transiently inhibited causing tension or distress
|
Blocking
|
|
|
Main s/e of Clonidine
|
Sedation
|
|
|
Tx for
ADHD with tics |
Stimulants anyway
|
|
|
Is punishment useful at age 4?
|
No, good modeling will build moral code but right and wrong are not understood well enough for punishment
|
|
|
Tx for
Panic Disorder |
SSRI
|
|
|
Process of adopting other people's characteristics
|
Identification
|
|
|
A defense mechanism in which emotions are shifted from one idea or object to another that resembles the original but evokes less distress
|
Displacement
|
|
|
A defense mechanism in which a person's character or sense of identity is temporarily but drastically modified in order to avoid emotional distress
|
Dissociation
|
|
|
Most vulnerable month of pregnancy for mental illness
|
1st
|
|
|
Consistent failure to speak a specific social situation despite speaking in other situations
|
Selective mutism
|
|
|
Most common abuser of children
|
The mother
|
|
|
Must have this before 15 yo
|
CD for Antisocial dx (must be at least 18)
|
|
|
Lab changes in Anorexia nervosa
|
1) High cholesterol
2) High corticotropin releasing hormone 3) Hypogylcemia 4) Hypothyroidism 5) Leukopenia |
|
|
Inability to perform learned motor skills
|
Apraxia
|
|
|
Inability to recognize objects
|
Agnosia
|
|
|
Inability to name objects even after recognizing them
|
Anomia
|
|
|
Inability to read
|
Alexia
|
|
|
Inability to express or comprehend language
|
Aphasia
|
|
|
Infection associated with OCD and Tourette's
|
Group A Strep
(Sreptococcus) |
|
|
Dx
Toxocara and viscereal larva migrans |
Pica
|
|
|
Lab abnormalities in bulimia
|
1) Low K
2) Low Na 3) Low Cl 4) Metabolic alkalosis |
|
|
Dx
Rectal bleeding and anemia |
Stereotypic Movement Disorder
|
|
|
Most likely to abuse substances
|
CD
|
|
|
Dx
Chapped, erythematous hands |
OCD
(from hand washing) |
|
|
Dx study for trouble reading
|
Vision test
|
|
|
Dx
Girl reached normal early milestones but now does not speak anywhere |
Rett
|
|
|
Dx
Trouble in school, avoids classmates, odd movements with hands |
Autism
|
|
|
MR cut offs
|
Mild - 70-55
Moderate - 54-40 Severe - 39-25 Profound - Less than 25 |
|
|
Nihilistic Delusional Content
|
Cotard Syndrome
|
|
|
Believe people are replaced by imposters
|
Capgras Syndrome
|
|
|
Most common cause of postpartum psychosis
|
Bipolar disorder
|
|
|
Dx
Rapid mood swings, efforts to avoid abandonment, chronic feelings of emptiness, intense anger outbursts, impulsivity, fluctuations between idealization and devaluation, and recurrent self mutilation or suicidality. |
BPD
|
|
|
Dx
Non bizarre delusion, high level of social and occupational functioning |
Delusional disorder
|
|
|
Tx
Severe depression, poor response to many medications, and poor compliance despite attempts |
ECT
|
|
|
What not to prescribe for bipolar disorder
|
Antidepressants (can cause mania)
but you can prescribe if predominantly depressed and carefully |
|
|
What sleep disturbance is most common with depression
|
Early morning awakening
|
|
|
Lab results in depression (3)
|
Increased cortisol
Decreased catecholamines Decreased immune function |
|
|
Tx for
Cyclothymia |
Same as for bipolar disorder
|
|
|
Risk of mood disorder in first degree relatives of bipolar people
|
25% for mood disorder
|
|
|
What must always be ruled out in mania?
|
Cocaine or other drug intoxication
|
|
|
Dx
Psychotic or mood symptoms with abdominal pain |
Porphyria
|
|
|
Dx
Inpt visual hallucinations |
Delirium
|
|
|
Risk of mood disorder if first degree relative has bipolar
|
25% for mood disorder
|
|
|
What must you rule out in mania?
|
Cocaine or other drug intoxication
|
|
|
Dx
Psychotic or mood symptoms with abdominal pain |
Porphyria
|
|
|
Dx
Inpt with visual hallucinations |
Delirium
|
|
|
Dx
Docility, lack of fear response, anterograde amnesia, hyperhapgia, hypersexuality |
Kluver-Bucy
|
|
|
Area of Kluver bucy; aggression, sexual behavior, and fear responses
|
Amygdala (need bilateral damage for kluver bucy)
|
|
|
Area involved with complex auditory information like language
|
Superior temporal gyri
|
|
|
Dx
Binging and purging with less than 85% ideal body weight |
Anorexia nervosa binging purging type
|
|
|
Lab abnormalities in anorexia (5)
|
1) Elevated BUN (from increased catabolism)
2) Increased cortisol 3) TSH and TRH normal 4) Anemia 5) Elevated growth hormone |
|
|
What percentage of MDD patients respond to a dexamethasone challenge?
|
50%
|
|
|
Thryoid abnormality in MDD
|
No increased in TSH from TRH challenge (TRH insensitive in 30% of people)
|
|
|
Methadone does not cause bone decay or decreased libido
|
Despite popular belief
|
|
|
Tx for
Postpartum psychosis |
Inpt hospitalization
|
|
|
s/e
Dry mouth, dizziness, urinary hesitancy |
TCAs
Imipramine |
|
|
s/e
GI upset, sexual dysfunction, agitation |
SSRIs
|
|
|
s/e
Hypotension, less likely anticholinergic |
MAOIs
(Phenelzine) |
|
|
s/e
Polyuria, polydipsia, tremor, mental confusion |
Li
|
|
|
s/e
GI upset, sedation, tremor |
VPA
|
|
|
Dx
Hypointensities in subcortical areas |
Lacunar Strokes
|
|
|
Dx
Cerebellar atrophy |
Congenital disorder or
Alcoholism |
|
|
Lab results in alcoholism (3)
|
1) Increased GGT
2) Increased uric acid, 2:1 AST:ALT 3) Macrocytic anemia |
|
|
ddx between PTSD, Acute stress disorder, and Adjustment disorder
|
PTSD and ASD are the same except if it lasts 4 weeks or less it's ASD.
Adjustment disorder can be either anxiety, conduct, or mood, and must happen within 3 months of an event, that MUST be NON-TRAUMATIC |
|
|
Suicide rates in schizophrenics and general
|
Schizophrenics - 10%
General - less than 1% |
|
|
Feelings and attitudes originating from the treater evoked by the patient
|
Countertransferance
|
|
|
Is ECT indicated for psychosis
|
yes
|
|
|
ECT sessions for
Catatonia - MDD - Mania - Permanent memory impairment - |
Catatonia - 2-4
MDD - 6-12 Mania or Psychosis - 20 or more Permanent memory impairment - 20-40 |
|
|
Tx for
OCD |
SSRIs
1st line |
|
|
Placebo efficacy for MDD
|
30% of pts respond
|
|
|
Pharmacotherapy efficacy for MDD
|
65-75% of patients will improve with SSRIs or TCAs
|
|
|
Dx
Predominance of motor behaviors and nonverbal forms of communication such as facial experessions in schizophrenia |
Schizophrenia Catatonic type
|
|
|
Dx
Sexual pleasure from experiencing pain, no sexual dysfunction or marked distress |
No diagnosis
Only pathological if it causes distress or occupational/social dysfunction |
|
|
Dx
Repeated nightmares that cause distress but doesn't fit PTSD |
Nightmare disorder
|
|
|
Dx
Excessive drowsiness and many hours sleeping |
Primary hypersomnia
|
|
|
The risk of completed suicide in MDD is
|
10-15%
|
|
|
Tx for
PTSD |
SSRIs
|
|
|
Tx for
Panic Disorder |
SSRI with CBT
|
|
|
Mean age of onset for bipolar disorder
|
30
|
|
|
Infarcts of the Left middle cerebral artery to the left frontal hemisphere cause what?
|
Depression
|
|
|
Diffuse damage to bilateral frontal hemispheres leads to what?
|
OCD
|
|
|
Infarcts to the Right frontal hemisphere lead to what?
|
Euphoria, inappropriate indifference, or mania
|
|
|
In men under 50 what percentage of impotence is psychological?
|
90%
|
|
|
Neurotransmitter correlation in suiciders, violence, agrees, and impulsivity
|
Decreased 5-HIAA (a serotonin metabolite)
|
|
|
Dx
Diffuse white matter plaques affecting frontal lobes |
MS (w/ depression)
|
|
|
Dx
Ventricular enlargment and cerebral atrophy |
Alzheimer's dementia
|
|
|
Worst prognostic indicator for schizophrenia
|
Predominantly negative symptoms
|
|
|
Risk of schizophrenia with 1 or 2 parents
|
1 parent = 12%
2 parents = 40% |
|
|
Dx
Short term memory deficits, smooth pursuit eye movement problems, decreased sensory habituation |
Schizophrenia
|
|
|
Tx for
Passive suicidal ideation with recent plan |
Inpt hospitalization
|
|
|
Risk factors for completed suicide
|
1) White
2) male 3) older 4) single 5) Protestant or jewish |
|
|
Believing an event relates to you when it does not
|
Ideas of reference
|
|
|
Belief that thoughts from an external entity are placed in your mind
|
Thought insertion
|
|
|
Belief that one's body parts are diseased (like rotting)
|
Somatic delusion
|
|
|
Belief that others know what you are thinking
|
Thought broadcasting
|
|
|
Forgetting of time around a specific event
|
Localized amnesia
|
|
|
Forgetting of some aspects of an event, while remembering others
|
Selective amnesia
|
|
|
Forgetting everything before a certain event
|
Retrograde amnesia
(Generalized if they've forgotten no parts, but everything from before) |
|
|
Forgetting all events following a trauma except immediate past
|
Continuous amnesia
|
|
|
RFs for Schizophrenia
Parent - Both parents - Identical twin - Fraternal twin - Sibling - |
Parent - 12%
Both parents - 40% Identical twin - 50% Fraternal twin - 12% |
|
|
Thought processes:
|
Circumstantial - superfluous details but gets there
Tangential - relevant but doesn't get there Flight of ideas - Extreme tangentiality that birdwalks quickly Loosening of assocations - series of disconnected ideas Word salad - Completely disorganized |
|
|
Dx
Epileptic like activity but with purposeful movements |
Pseudoseizure (as seen in stress, personality disorders, or conversion reactions)
|
|
|
REM changes in depression
|
1) decresed REM latency
2) REM redistributed to first half of night |
|
|
Transient loss of motor tone associated with strong emotions
|
Cataplexy
|
|
|
State of immobility seen in catatonic patients
|
Catalepsy
|
|
|
The belief that you have an exact counterpart
|
Doppleganger
|
|
|
Belief that you are poisoned by a spirit
|
Cacodemonomania
|
|
|
Ascribing of personal meaning or messages that are not intended
|
Delusion of reference
|
|
|
Belief that nothing exists, including the patient's body to the point that they feel they are rotting away
|
Cotard syndrome
|
|
|
The belief that a single person is impersonating everyone
|
Fregoli syndrome
|
|
|
Dx
Formication |
Cocaine intoxication or
EtOH withdrawal |
|
|
Slowed or absent movement
|
Akinesia
|
|
|
Mental activity no in accordance with reality
|
Dereism
|
|
|
Abnormal recall of events
|
Hypermnesia
|
|
|
Loss of memory without loss of ability to make new memories, usually associated with trauma
|
Dissociative Amnesia
|
|
|
Inability to recognize something by touch
|
Astereognosis
|
|
|
Uncontrollable or excessive talking as seen in mania
|
Logorrhea
|
|
|
Fluent fabrication of fictitious responses in response to memory problems
|
Confabulation
|
|
|
irregular pauses between syllables
|
Scanning speech
|
|
|
Stopping speech abruptly then picking up with a new topic
|
Derailment
|
|
|
The persistence of an image after it has been removed
|
Palinopsia
|
|
|
Areas of brain implicated in OCD (3)
|
Caudate nucleus
Frontal lobes Cingulum |
|
|
Describing things but not naming them
|
Circumlocution
|
|
|
Physical manifestations of underlying unconscious motivations or drives
|
Conversion disorder
|
|
|
Areas of brain implicated in Schizophrenia
(2) |
Hippocampus
Amygdala |
|
|
Area of brain involved in anxiety
|
Locus Ceruleus
NE made here |
|
|
Dx
Tachycardia, flushing, fever, hypertension, ocular osscilations, and myoclonic jerks. |
Serotonin syndrome
|
|
|
How long to wait after TCA to start SSRI
|
14 days
|
|
|
Where is serotonin made in brain
" " Ne " " Dopamine |
Raphe nucleus
Locus ceruleus Substantia nigra |
|
|
Dx
Ataxia, eye paralysis, nystagmus, confusion, anterograde amnesia |
Wernicke's encephalopathy
(Vit B1 (thiamine) deficiency) |
|
|
Dx
Anterograde amnesia, retrograde amnesia, confabulation, apathy, lack of insight |
Korsakoff's Psychosis
|
|
|
You can get Wernicke's encephalopathy and Korsakoff psychosis together
|
Usually the delirium of wernicke masks the korsakoff but with thiamine treatment it becomes more apparent
|
|
|
If the delusion is short
-if non bizarre -if bizarre |
-if non bizarre - Delusional disorder
-if bizarre - brief psychotic episode |
|
|
Greatest predictor of suicide
|
Age over 45 and mood disorder
|
|
|
Gluccocorticoids can cause what
|
Reversible psychiatric symptoms of depression and psychosis
|
|
|
Difficulty with simple math
|
Dyscalculia
|
|
|
Ability to speak a new language
|
Glossolalia
|
|
|
Repetitive and meaningless talk
|
Verbigeration
|
|
|
Tx for
MAOI caused autonomic excitability |
IV Lorazepam
|
|
|
Contraindicated fro MAOIs
|
Stimulants
Decongestants L-dopa Reserpine |
|
|
Dx
Hypersomnia, weight gain, mood reactivity |
Atypical depression
|
|
|
Tx for
Atypical Depression |
MAOI
(Phenelzine or Tranylcypromide) |
|
|
Minimum trial period for an anti-depressant
|
6 weeks
|
|
|
Tx for
Delirium with liver disease |
Lorazepam or oxazepam
(not metabolized by liver) |
|
|
What do low potency anti-psychotics do to seizure threshold?
|
Lower it
|
|
|
Tx for
DTs |
IV benzos
|
|
|
Why do SSRIs take so long
|
Time to downregulate the 5-HT2 receptor
|
|
|
Most common sexual side effect of SSRIs in women
|
Anorgasmia
|
|
|
Tx for
Akisthesia (walking a lot) |
1) Reduce neuroleptic agent
2) Propanolol |
|
|
Tx for
Acute dystonia |
Diphenhydramine
|
|
|
Most serious complication of NMS
|
Rhabdo
|
|
|
s/e of
Thioridazine (typical antipsychotic) |
Retinal pigmentation
|
|
|
Dx
Retinal pigmentation |
Thioridazine
|
|
|
Tx for
Panic disorder |
SSRIs, TCAs, or MAOIs
|
|
|
Most potent benzo
|
Clonazepam
|
|
|
Preliminary tests to start Li
|
1) Electrolytes, BUN, and UA bc Li is renally excreted
2) Thyroid studies bc Li inhibits thyroid production and release 3) CBC is optional bc of benign elevation in WBCs |
|
|
Avoid NSAIDs with Li, switch to what?
|
Aspirin
|
|
|
Which nt to block in Tourette's
|
Dopamine
hence use |
|
|
Tx for
Tourette's |
Haloperidol is more potent
but Clonidine is first line bc no EPS or other s/e |
|
|
Indication for
Busprirone |
GAD
|
|
|
Pharmacotheraphy for
BPD |
1) Fluoxetine 1st line
2) Add Antipsychotics (haloperidol or clozapine) for impulsiveness 3) Add VPA for mood fluctuations |
|
|
Pharmacotheraphy for
Bulimia |
Fluoxetine
|
|
|
Pharmacotherapy for
Anorexia |
None indicated, appetite increasers don't work
|
|
|
Dx
Dizziness, n/v, fatigue, lethargy, flu like symptoms Most commonly caused by - Tx - |
SSRI discontinuation syndrome
Most commonly caused by - Paroxetine (short half life) Tx - Add back paroxetine and taper |
|
|
Pharmacotherapy for
MDD with Carbamazepine for epilepsy |
Paroxetine
(others increase carb levels) |
|
|
What EKG abnormality does Li cause?
|
1) Benign T wave flattening or inversion
2) Then basically every arrhythmia under the sun |
|
|
Which drugs increase Li levels?
(5) |
1) Thiazide diuretics
2) Spironolactone 3) NSAIDs except asa and sulindac 4) Metronidazole and Tetracycline 5) ACE-Is |
|
|
Pharmacotheraphy for
OCD |
Clomipramine
(TCA with potent serotonin activity) SSRIs are second line |
|
|
How does gedon (ziprasidone work)
|
D2 and 5HT2a receptor blockade
Atypical antipsychotic |
|
|
Tx for
Antipsychotic resistant psychosis Why? |
Clozaril
Has more blockade activity at D4 than D2, as well as 5HT2a blockade |
|
|
Blocking what causes orthostatic hypotension
and what drugs do it |
Blocking alpha-1
TCAs block it Mitzapine does not, it blocks alpha-2 |
|
|
Tx for
SSRI resistant depression |
Venlafaxine (SNRIs)
|
|
|
Congenital defects with mood stabilizers
Li - VPA - Carbamazepine - |
Li - Ebstein valve anomaly
VPA - Neural tube defects Carbamazepine - Neural tube defects |
|
|
Tx for
Agitation in delirious old people |
Risperidone or other atypical anti psychotics
(Benzos can paradoxically disinhibit, and diphenhydramine can worsen delirium with anticholinergic effects) |
|
|
Tx for
MDD with anorexia and insomnia |
Mertazapine
|
|
|
Avoid TCAs with which CV abnormalities
|
Heart block, wide QRS, BBB
|
|
|
Tx for
Delirium in elderly |
Haloperdiol (least risk of orthostasis)
|
|
|
Tx for
Antipsychotic resistant psychosis Why? |
Clozaril
Has more blockade activity at D4 than D2, as well as 5HT2a blockade |
|
|
Antipsychotic with least orthostatic effects
|
Haloperidol
|
|
|
Blocking what causes orthostatic hypotension
and what drugs do it |
Blocking alpha-1
TCAs block it Mitzapine does not, it blocks alpha-2 |
|
|
Tx for
PTSD |
SSRIs
|
|
|
Tx for
SSRI resistant depression |
Venlafaxine (SNRIs)
|
|
|
Congenital defects with mood stabilizers
Li - VPA - Carbamazepine - |
Li - Ebstein valve anomaly
VPA - Neural tube defects Carbamazepine - Neural tube defects |
|
|
Tx for
Agitation in delirious old people |
Risperidone or other atypical anti psychotics
(Benzos can paradoxically disinhibit, and diphenhydramine can worsen delirium with anticholinergic effects) |
|
|
Tx for
MDD with anorexia and insomnia |
Mertazapine
|
|
|
Avoid TCAs with which CV abnormalities
|
Heart block, wide QRS, BBB
|
|
|
Tx for
Delirium in elderly |
Haloperdiol (least risk of orthostasis)
|
|
|
Antipsychotic with least orthostatic effects
|
Haloperidol
|
|
|
Tx for
PTSD |
SSRIs
|
|
|
Pharmacotherapy for
Re-experiencing and hyperarousal acutely |
Clonidine
|
|
|
Pharmacotherapy for
Alzheimer's |
Donepezil (aricept)
|
|
|
Tx for
Unknown drug overdose of downers |
Fluids, naloxone, and thiamine
Not flumazenil (lowers seizure threshold) |
|
|
What do you use to detox from heroin
|
For 1st time detoxers - Clonidine
For repeated relapsers - Methadone |
|
|
Tx for
MDD and smoking cessation |
Bupropion
|
|
|
Tx for
Bipolar disorder with neuropathic pain |
Gabapentin
|
|
|
s/e of Risperidone
|
Blocks 5HT2a, D2, alpha 1 so causes
Weight gain, orthostasis |
|
|
How is Clozaril different than all the other atypicals
|
While atypicals have less EPS s/e than typicals, only clozaril has none. All the others cause EPS at high doses
|
|
|
Where do hallucinations happen in brain?
EPS symptoms? Prolactin problems? |
Mesolimbic system for hallucinations
Nigrostriatal system for EPS Tuberoinfundibular for prolactin |
|
|
Pharmacotherapy option for
Impotence |
Yohimbine
|
|
|
Alpha-2 Receptor drugs
|
Mirtazapine - Alpha-2 Antagonist
(indirect 5HT1 agonist and NE agonist) Clonidine - Alpha-2 Agonist Yohimbine - Alpha-2 Antagonist (also increased NE) |
|
|
Clozapine =
Clonazepam = |
Clozapine = Clozaril the antipsychotic
Clonazepam = Klonopin the benzo |
|
|
Mood stabilizer therapy during pregnancy
|
ECT is 1st line but rarely taken
(usually they keep on Li despite cardiac teratogenicity) |
|
|
Which mood stabilizer causes pancreatitis?
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VPA
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Which antipsychotic causes hyperglycemia?
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Clozapine
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Which antipsychotic interacts with citalopram?
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Pimozide
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1st line Depot injection antipsychotic
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Risperidone (bc atypical), the only other depot being haldol
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Tx for
Unknown drug overdose of downers |
Fluids, naloxone, and thiamine
Not flumazenil (lowers seizure threshold) |
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What do you use to detox from heroin
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For 1st time detoxers - Clonidine
For repeated relapsers - Methadone |
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Tx for
MDD and smoking cessation |
Bupropion
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Tx for
Bipolar disorder with neuropathic pain |
Gabapentin
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s/e of Risperidone
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Blocks 5HT2a, D2, alpha 1 so causes
Weight gain, orthostasis |
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How is Clozaril different than all the other atypicals
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While atypicals have less EPS s/e than typicals, only clozaril has none. All the others cause EPS at high doses
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Pharmacotherapy for
Re-experiencing and hyperarousal acutely |
Clonidine
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Pharmacotherapy for
Alzheimer's |
Donepezil (aricept)
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Which drug causes nephrogenic diabetes insipidus?
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Li (causes pissing)
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Which antipsychotic has highest risk of metabolic syndrome?
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Olanzapine
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Minimum and recommended trial length for first antidepressant in life
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6 month minimum with
10 month recommendation |
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Tx for
Sialorrhea from clozapine |
Propylthiouracil
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Tx for
Clozapine induced tachycardia |
Propanolol (not labetalol which can exacerbate hypotension)
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Contraindications for ECT (2)
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1) Recent MI
2) Brain occupying lesion (brain stem herniation risk) |
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Only antipsychotic known to decrease suicidality in schizophrenia?
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Clozapine
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Aplastic anemia is a s/e of what?
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Carbamazepine
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HTN is a s/e of what?
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Venlafaxine
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Opisthotonos -
Pleurothotonos - Torticollis - Oculogyric crisis - Laryngospasm - |
Opisthotonos -
Pleurothotonos - Arching of back Torticollis - SCM spasm pulling neck to one side Oculogyric crisis - Spasm of extraocular muscle Laryngospasm - Spasm of tongue or throat, can lead to respiratory distress |
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Antidepressant that works for diabetic neuropathy
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Duloxetine (an SNRI)
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Spasm of the eyelid
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Blepharospasm
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Rapid movement of the lips is an EPS s/e called?
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Rabbit syndrome
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Orthostatic hypotension is caused by blockade of what?
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Alpha1
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Dx
Yellow skin with chlorpromazine |
Obstructive jaundice
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Dx
Lack of ejaculation on antipsychotics |
Retrograde ejaculation (not anorgasmia like with SSRIs)
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When does alcohol withdrawal strike?
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48-96 hours
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Alcohol and benzos agonize which GABA receptor?
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GABA-A
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MAOIs increase NE, 5HT, and DA.
What is A and B |
MAO-A = 5HT and NE
MAO-B = DA (antiparkinson) |
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What cardiac effect do TCAs have?
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Torsades de pointes
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Special TCA indications:
Pain syndromes - OCD - Enuresis - Elderly Depression - |
Pain syndromes - Amytriptyline
OCD - Clomipramine Enuresis - Imipramine Elderly Depression - Nortriptyline |
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Useful as adjunctive therapy for depression.
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Buspirone (partial 5HT1 agonist)
Also Bupropion |
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Fatal s/e of
Nefazadone |
Fatal hepatitis
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Lithium
Range: S/e: Teratogenicity: |
Range: 0.8-1.0
S/e: Neurotoxicity, hypothyroid, diabetes insipidus, leukocytosis, GI Teratogenicity:Ebsteins anomaly |
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Carbamazepine (Tegretol)
Range: S/e: Teratogenicity: |
Range: 8-12
S/e: Autoinducer at liver (VPA will decrease with acclimation in a few weeks), SJ rash, Aplastic anemia Teratogenicity:Craniofacial defect |
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Valproate
Range: S/e: Teratogenicity: |
Range: 80-120
S/e: Heptatitis, aplastic anemia, sedation, weight gain Teratogenicity: Neural tube defect |
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Lamotrigine (Lamictal)
Range: S/e: Teratogenicity: |
S/e: SJ RASH is big
Teratogenicity: |
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Tx for Opiate withdrawal
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Methadone, suboxone, buphrenorphine, naltrexone/naloxone
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Alcohol withdrawal therapy
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Acamprosate (decrease glutamate response)
Naltrexone Disulfiram |
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Dementia Tx meds
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Donepezil (ACh-esterase inhibitor)
Memantine (NMDA receptor antagonist) |
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Specific to
Olanzapine |
Worst metabolic side effects, sedating.
Must be combined with fluoxetine for mood stabilization. |
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Specific to
Risperidone |
Most typical of the atypicals, available in dec shot
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Specific to
Seroquel |
Extremely sedating, causes orthostasis
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Specific to
Ziprasidone |
QT prolongation issue
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Specific to
Aripiprazole |
Partial DA agonist (even though anti-psychotic), weakest of all
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Specific to
Clozapine |
Aplastic anemia (agranulocytosis), seizures, cardiomyopathy, hypotension,
Only antipsychotic to decrease suicide with Li |
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Depression, agoraphobia, GAD, and substance abuse are associated with what?
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Panic Disorder
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Requirements for panic disorder
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3 attacks in 3 weeks
No stimulus Peak of sx within 10 minutes |
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Mgmt
Adolescent with change in behavior |
Drug screen
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Mgmt
Refractory mania on a mood stabilizer |
Blood levels of mood stabilizer
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Dx
Sudden onset neurological complains with obvious stressor |
Conversion disorder
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Dx
Impaired sleep, poor concentration, easy fatigability, irritability, muscle tension |
GAD
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1st line therapy for
Tourette's |
Pimozide or
Haloperidol |
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Tx for
Anorexia nervosa |
1) If under 75% body weight --> hospitalize
2) CBT is helpful 3) SSRIs for weight maintenance, depression, and binging/purging |
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Dx
Auditory, visual hallucinations, with normal vital signs and intact sensorium |
Alcoholic hallucinosis
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Cannot make acute psychotic episode dx if drugs or alcohol are likely contributors to symptoms
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!
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When to stop Li for young people with manic episodes?
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1 manic episode - 1 year of Li then taper off
3 or more manic episodes - Lifelong Li |
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Risks of pregnancy with current or previous dx of anorexia (5)
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1) Miscarriage
2) Intrauterine growth retardation 3) Premature birth 4) C section 5) Post partum depression |
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Common findings in Anorexia (6)
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1) Osteoperosis
2) Elevated cholesterol and carotene levels 3) Prlonged QT 4) Euthyroid sick syndrome 5) Anovulation, amenhorrhea, and low estrogen 6) Hyponatremia from excess water drinking |
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Dx
Loss of normal skills after 2 years in language, social, sphincter control, or motor skills |
Childhood disintegrative disorder
(looks like autism, except autistics have sx before age 3 always if observed properly) |
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Mgmt
Suicidal patient who doesn't want inpt, and neither do parents |
Hospitalize anyway
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1st line Tx for
Enuresis |
Desmopressin
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Difference between adjustment d/o and normal human life with mild depressive sx to a stressor
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If affects level of functioning than adjustment disorder
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Dx
Replacing a less disturbing view of the world in place of reality to ease distress |
Fantasy (defense mechanism)
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Tx for
Somatization disorder |
Frequent regularly scheduled visits with their PCPs to reduce underlying psychological distress
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Monitoring for all atypicals
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Weight, glucose, and lipids
and BP |
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Defense mechanism in which a person assimilates another person's attitudes into one's own perspective
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Introjection
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Defense mechanism in which a person expresses his aggression toward another person with repeated failures to meet the other person's needs
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Passive-aggressive
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Difference between PCP and LSD intoxication
|
LSD has more visual hallucinations and intensified perceptions
While PCP has more aggression |
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Tx for
Bipolar w/ renal insufficiency |
VPA or Carbamazepine
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Associations with Tourette's (2)
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ADHD and OCD
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Attributing excessive negative qualities to another
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Devaluation
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Process by which repressed material particularly painful kinds are brought back to consciousness
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Abreaction
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Process of disclosing suppressed feelings, ideas, or events to other group members
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Ventilation
similar to catharsis without the emotional overtones both before or after |
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Hypnosis should not be used in which disorders?
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Psychosis
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Systematic desensitization uses what?
|
Reciprocal inhibition
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Dx
Abducent nerve palsy, nystagmus, ataxia, global confusion Cause? |
Wernicke's encephalopathy
caused by thiamine (B1 deficiency) |
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Dx study for suspected
Wernicke's encephalopathy |
Head CT
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Mgmt for
Command hallucinations |
Inpt hospitalization
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Fatal part of alcohol withdrawal
|
Seizures
|
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Tx for
Agitation in delirious elderly patient |
Low dose haldol
(Anticholinergics and lose potency typicals exacerbate delirium) Benzos cause paradoxical inhibition |
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Dx
Complaints with at least one pain and one neurological |
Somatization disorder
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Tx for
MDD with delusions but not hallucinations |
Still an antipsychotic and an antidepressant
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Tx for
Adjustment disorder |
Psychotherapy
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Dx
Neurologic symptoms with no clear pathology |
Conversion disorder
|
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|
S/e of Pimozide
Monitoring test |
Pronlonged QT
Get EKG |
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|
Dx
Sensory aurus and automatic behaviors |
Complex partial seizure
|
|
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Dx
HTN, diaphoresis, palpitations, anxiety fear |
Pheochromocytoma
or Panic Attack |
|
|
Dx
Dementia, weakness, imbalance, congitive decline, social withdrawal |
HIV associated dementia
|
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Dx
Depressive, mild cognitive impairment especially with math,tremor, brisk reflexes |
Hyperthyroid
|
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Dx
Recent change in personality, angry, headaches, pains, fever |
SLE associated lupus psychosis
|
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Dx
Tachy, tremor, HTN, seizure |
Hypoglycemia
|
|
|
Delirium work up
|
CBC
Chem 7 PRP B12/Folate TSH Ca/Mg UDS LFTs O2 sat |
|
|
Dx
Nystagmus, HTN, tachy, pain tolerance, muscular rigidity |
PCP
|
|
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Dx
Dysphoria, SI, unpleasant dreams, hunger, fatigue |
Cocaine withdrawal
|
|
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Dx
Dysphoria, fever, nausea, vomiting, muschle aches, |
Opiate withdrawal
|
|
|
Wernicke's encephalopathy signs (3)
|
ACE
Ataxia Confusion Eye movements |
|
|
Lesions in Korsakoff are where
|
Mamillary bodies and Thalamus
|
|
|
The delusions that are mood congruent can sometimes be attributed to depression with psychosis
|
.
|
|
|
Lesions in Korsakoff are where
|
Mamillary bodies and Thalamus
|
|