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19 Cards in this Set
- Front
- Back
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biotransformation
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metabolism
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blocker
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antagonist
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blood-brain barrier
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selective mechanism that opposes the passage of most ions and large molecular compounds from the blood to the brain tissue
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clearance
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rate of disappearance of the drug molecules from circulation
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distribution
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the delivery of the drug into any and all body compartments it can penetrate
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excretion
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removal of a drug (or its metabolites) from the body
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first-pass effect
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drugs entering the body by the enteral route first go through the portal circulation to the liver before reaching the general circulation
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half-life
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the time needed for the plasma concentration of a drug to be reduced to 50%
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intrinsic activity
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a combination of affinity and efficacy
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metabolism
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conversion of the rug into another substance or substances
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metabolites
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end product of chemical change of one drug into another
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P-450
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enzyme system to metabolize drugs
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placebo
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inactive substance
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prodrug
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drug that requires conversion into its active form
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pharmacotherapeutics
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reason the drug is prescribed
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steady state
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administration rate of a drug equals its elimination rate
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therapeutic index
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relation of ED50 + LD50
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primary site for metabolism
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liver
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affinity
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the attraction of certain molecules to specific sites
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